Substance Use Disorders and Risk for Completed Suicide

Substance use disorders are among the most frequent psychiatric disorders found in suicides. In psychological autopsy studies between 19% and 63% of all suicides suffered from substance use disorders, mostly from alcohol use disorders. Suicide risk is highly increased in substance use disorders, particularly in alcohol use disorders, and in co-morbid alcoholism and depression. So far, some risk factors for suicide have been identified in alcoholism. Nevertheless, various questions about the relationship between substance use disorders and suicide remain open, which indicate directions for future research.

[1]  J. Wootton Alcohol abuse , 2020, Journal of women's health.

[2]  L. Vijayakumar,et al.  Are risk factors for suicide universal? A case‐control study in India , 1999, Acta psychiatrica Scandinavica.

[3]  E. Caine,et al.  Suicide in Later Life: Psychological Autopsy Findings , 1991, International Psychogeriatrics.

[4]  D. Brent,et al.  Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. , 1996, Archives of general psychiatry.

[5]  G. Benson,et al.  Drug‐related mortality in young people , 1984, Acta psychiatrica Scandinavica.

[6]  E. Robins,et al.  Multiple risk factors predict suicide in alcoholism. , 1992, Archives of general psychiatry.

[7]  J. Lönnqvist,et al.  Employment status influences the weekly patterns of suicide among alcohol misusers. , 1997, Alcoholism, clinical and experimental research.

[8]  P. Allebeck,et al.  A trial that failed, and the reasons why: comparing the Minnesota model with outpatient treatment and non-treatment for alcohol disorders. , 1990, Scandinavian journal of social medicine.

[9]  H. S. Ripley,et al.  A study of suicide in the Seattle area. , 1960, Comprehensive psychiatry.

[10]  A. Beautrais,et al.  Risk factors for suicide and medically serious suicide attempts among alcoholics: analyses of Canterbury Suicide Project data. , 2003, Journal of studies on alcohol.

[11]  Y. Conwell,et al.  Culture, risk factors and suicide in rural China: a psychological autopsy case control study , 2004, Acta psychiatrica Scandinavica.

[12]  L. Sher The role of the hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of alcohol misuse and suicidal behavior in adolescents , 2007, International Journal of Adolescent Medicine and Health.

[13]  B. Runeson Mental disorder in youth suicide , 1989, Acta psychiatrica Scandinavica.

[14]  A. Derrick,et al.  Comorbidity of mental disorders in the post-mortem diagnosis of completed suicide in children and adolescents. , 1988, Journal of affective disorders.

[15]  B. Barraclough,et al.  A Hundred Cases of Suicide: Clinical Aspects , 1974, British Journal of Psychiatry.

[16]  T. Wetterling,et al.  Nicotine use in suicides: a case–control study , 2005, European Psychiatry.

[17]  A. Mann,et al.  Personality disorder and suicide , 1997, British Journal of Psychiatry.

[18]  R. Fowler,et al.  Some differences between men and women who commit suicide. , 1988, The American journal of psychiatry.

[19]  D. Brent,et al.  Risk factors for adolescent suicide. A comparison of adolescent suicide victims with suicidal inpatients. , 1988, Archives of general psychiatry.

[20]  K. Marinković,et al.  Alcoholism and the Brain: An Overview , 2003, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[21]  P. Duberstein,et al.  Age-related patterns of factors associated with completed suicide in men with alcohol dependence. , 1999, The American journal on addictions.

[22]  A. Lesage,et al.  Suicide and mental disorders: a case-control study of young men. , 1994, The American journal of psychiatry.

[23]  J. Lönnqvist,et al.  Alcohol-related problems among adolescent suicides in Finland. , 1999, Alcohol and alcoholism.

[24]  P. Gorwood Biological markers for suicidal behavior in alcohol dependence , 2001, European Psychiatry.

[25]  R. Fowler,et al.  San Diego suicide study. I. Young vs old subjects. , 1986, Archives of general psychiatry.

[26]  S. Li,et al.  Elderly suicide in Hong Kong – a case‐controlled psychological autopsy study , 2004, Acta psychiatrica Scandinavica.

[27]  P. Duberstein,et al.  Violence, alcohol, and completed suicide: a case-control study. , 2001, The American journal of psychiatry.

[28]  D. Thelle,et al.  Mortality in relation to smoking history: 13 years' follow-up of 68,000 Norwegian men and women 35-49 years. , 1993, Journal of clinical epidemiology.

[29]  D. Brent,et al.  Risk factors for completed suicide among adolescents with a lifetime history of substance abuse: a case‐control study , 1993, Acta psychiatrica Scandinavica.

[30]  M. Oquendo,et al.  The biology of impulsivity and suicidality. , 2000, The Psychiatric clinics of North America.

[31]  J. Lönnqvist,et al.  Mental disorders and comorbidity in suicide. , 1993, American Journal of Psychiatry.

[32]  S. Pirkola Alcohol and other substance misuse in suicide , 1999 .

[33]  P. Duberstein,et al.  Age differences in the personality characteristics of suicide completers: preliminary findings from a psychological autopsy study. , 1994, Psychiatry.

[34]  A. Beautrais,et al.  Moderators of the relationship between alcohol dependence and suicide and medically serious suicide attempts: analyses of Canterbury Suicide Project data. , 2003, Alcoholism, clinical and experimental research.

[35]  A. Amundsen,et al.  Alcohol abuse and suicide: a 40-year prospective study of Norwegian conscripts. , 1995, Addiction.

[36]  J. Tiihonen,et al.  Dopamine and alcoholism: neurobiological basis of ethanol abuse , 2004, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[37]  N. Kreitman,et al.  Risk factors for suicide and undetermined death among in-patient alcoholics in Scotland. , 1993, Addiction.

[38]  P. Allebeck,et al.  Suicide among young men: psychiatric illness, deviant behaviour and substance abuse , 1990, Acta Psychiatrica Scandinavica.

[39]  E. L. Mortensen,et al.  Alcohol use disorders increase the risk of completed suicide — Irrespective of other psychiatric disorders. A longitudinal cohort study , 2009, Psychiatry Research.

[40]  S. Tsugane,et al.  Cigarette smoking and completed suicide among middle-aged men: a population-based cohort study in Japan. , 2005, Annals of epidemiology.

[41]  J. Bertolote,et al.  Suicide and psychiatric diagnosis: a worldwide perspective. , 2002, World psychiatry : official journal of the World Psychiatric Association.

[42]  J. Lönnqvist,et al.  Differences in recent life events between alcoholic and depressive nonalcoholic suicides. , 1994, Alcoholism, clinical and experimental research.

[43]  J Beskow,et al.  Suicide in mental disorder in Swedish men. , 1979, Acta psychiatrica Scandinavica. Supplementum.

[44]  P. Allebeck,et al.  Mental disorder in elderly suicides: a case-control study. , 2002, The American journal of psychiatry.

[45]  H. Wilcox,et al.  Association of alcohol and drug use disorders and completed suicide: an empirical review of cohort studies. , 2004, Drug and alcohol dependence.

[46]  P. Duberstein,et al.  Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study. , 1996, The American journal of psychiatry.

[47]  D. Brent,et al.  Age- and sex-related risk factors for adolescent suicide. , 1999, Journal of the American Academy of Child and Adolescent Psychiatry.

[48]  B. Bondy,et al.  Association between suicide attempts and 5-HTTLPR-S-Allele in alcohol-dependent and control subjects: further evidence from a german alcohol-dependent inpatient sample , 2001, Biological Psychiatry.

[49]  J. Lönnqvist,et al.  Suicide among subjects with personality disorders. , 1996, The American journal of psychiatry.

[50]  S. Darke,et al.  Suicide among heroin users: rates, risk factors and methods. , 2002, Addiction.

[51]  E. Demeter,et al.  Retrospective psychiatric assessment of 200 suicides in Budapest , 1988, Acta psychiatrica Scandinavica.

[52]  S J Samuels,et al.  Injury death excesses in smokers: a 1990–95 United States national cohort study , 2000, Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention.

[53]  J. Lönnqvist,et al.  Suicides of alcohol misusers and non-misusers in a nationwide population. , 2000, Alcohol and alcoholism.

[54]  Ernest E. Sullivent,et al.  Age of Alcohol Use Initiation, Suicidal Behavior, and Peer and Dating Violence Victimization and Perpetration Among High-Risk, Seventh-Grade Adolescents , 2008, Pediatrics.

[55]  D. Kriebel,et al.  Smoking at age 18-20 and suicide during 26 years of follow-up-how can the association be explained? , 2003, International journal of epidemiology.

[56]  E. Vartiainen,et al.  Smoking and the risk of suicide , 2000, Acta psychiatrica Scandinavica.

[57]  E. C. Harris,et al.  Suicide as an outcome for mental disorders , 1997, British Journal of Psychiatry.

[58]  J. Tonge,et al.  Suicide in Brisbane—A Retrospective Psychosocial Study , 1980, The Australian and New Zealand journal of psychiatry.

[59]  G. Colditz,et al.  Smoking and suicide among nurses. , 1993, American journal of public health.

[60]  D. K. Subbakrishna,et al.  Risk factors for completed suicides: a case–control study from Bangalore, India , 2004, Injury control and safety promotion.

[61]  K. Hawton,et al.  Psychiatric disorder and personality factors associated with suicide in older people: a descriptive and case‐control study , 2001, International journal of geriatric psychiatry.

[62]  D. Wasserman,et al.  The role of alcohol in suicide: a case-control psychological autopsy study , 2006, Psychological Medicine.

[63]  K. Hawton,et al.  Suicide in young people aged 15-24: a psychological autopsy study. , 2001, Journal of affective disorders.

[64]  M. Oquendo,et al.  Suicidal Behavior and Mild Traumatic Brain Injury in Major Depression , 2004, The Journal of nervous and mental disease.

[65]  M. Waern Alcohol dependence and misuse in elderly suicides. , 2003, Alcohol and alcoholism.

[66]  J. Angst,et al.  Personality, smoking and suicide: a prospective study. , 1998, Journal of affective disorders.

[67]  M. Oquendo,et al.  CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence , 2007, European Neuropsychopharmacology.

[68]  J. Deeks,et al.  Suicide in female nurses in England and Wales , 2002, Psychological Medicine.

[69]  E. Robins,et al.  Some clinical considerations in the prevention of suicide based on a study of 134 successful suicides. , 1959, American journal of public health and the nation's health.

[70]  D. Brent,et al.  Psychiatric risk factors for adolescent suicide: a case-control study. , 1993, Journal of the American Academy of Child and Adolescent Psychiatry.

[71]  V. Patel,et al.  Violence, psychological distress and the risk of suicidal behaviour in young people in India. , 2009, International journal of epidemiology.

[72]  J. Neaton,et al.  Smoking as "independent" risk factor for suicide: illustration of an artifact from observational epidemiology? , 1992, The Lancet.

[73]  G. Borges,et al.  Acute alcohol use and suicidal behavior: a review of the literature. , 2004, Alcoholism, clinical and experimental research.

[74]  E. Robins The final months : a study of the lives of 134 persons who committed suicide , 1981 .

[75]  A. Cheng Mental illness and suicide. A case-control study in east Taiwan. , 1995, Archives of general psychiatry.

[76]  M A Schuckit,et al.  Comparison of induced and independent major depressive disorders in 2,945 alcoholics. , 1997, The American journal of psychiatry.

[77]  C. Dolea,et al.  World Health Organization , 1949, International Organization.

[78]  T. Wetterling,et al.  [Risk factors for suicide in substance-related disorders]. , 2006, Psychiatrische Praxis.

[79]  B. Leistikow Commentary: Questionable premises, overadjustment, and a smoking/suicide association in younger adult men. , 2003, International journal of epidemiology.

[80]  R. McClelland,et al.  Mental disorders and suicide in Northern Ireland , 1997, British Journal of Psychiatry.

[81]  B. Barraclough,et al.  Excess mortality of mental disorder , 1998, British Journal of Psychiatry.

[82]  M. Blettner,et al.  Substance use disorders as risk factors for suicide in an Eastern and a Central European city (Tallinn and Frankfurt/Main) , 2009, Psychiatry Research.

[83]  J. Lönnqvist,et al.  Female psychoactive substance-dependent suicide victims differ from male--results from a nationwide psychological autopsy study. , 1999, Comprehensive psychiatry.

[84]  L. Appleby,et al.  Psychological autopsy study of suicides by people aged under 35 , 1999, British Journal of Psychiatry.

[85]  J. Lönnqvist,et al.  Mental Disorders in Elderly Suicide , 1995, International Psychogeriatrics.

[86]  E. Isometsä,et al.  Psychological autopsy studies – a review , 2001, European Psychiatry.

[87]  M. Sharpe,et al.  Psychological autopsy studies of suicide: a systematic review , 2003, Psychological Medicine.

[88]  M. Oquendo,et al.  Triggers for suicidal behavior in depressed older adolescents and young adults: Do alcohol use disorders make a difference? , 2007, International journal of adolescent medicine and health.

[89]  J. Lönnqvist,et al.  Psychosocial stressors more common in adolescent suicides with alcohol abuse compared with depressive adolescent suicides. , 1994, Journal of the American Academy of Child and Adolescent Psychiatry.

[90]  B. Barraclough,et al.  Lifetime risk of suicide for affective disorder, alcoholism and schizophrenia , 1998, British Journal of Psychiatry.

[91]  M. Hufford Alcohol and suicidal behavior. , 2001, Clinical psychology review.

[92]  J. Mann,et al.  Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism , 2003, Neuropsychopharmacology.

[93]  U. Åsgård A psychiatric study of suicide among urban Swedish women , 1990, Acta psychiatrica Scandinavica.

[94]  G. Borges,et al.  Suicide attempts and alcohol consumption in an emergency room sample. , 1996, Journal of studies on alcohol.

[95]  D Hemenway,et al.  Cigarette smoking and suicide: a prospective study of 300,000 male active-duty Army soldiers. , 2000, American journal of epidemiology.

[96]  J. Lönnqvist,et al.  Mental disorders in adolescent suicide. DSM-III-R axes I and II diagnoses in suicides among 13- to 19-year-olds in Finland. , 1991, Archives of general psychiatry.

[97]  D. Shaffer,et al.  Psychiatric diagnosis in child and adolescent suicide. , 1996, Archives of general psychiatry.

[98]  E. Rimm,et al.  Cigarettes and suicide: a prospective study of 50,000 men. , 2000, American journal of public health.

[99]  P. Allebeck,et al.  Cannabis and mortality among young men: a longitudinal study of Swedish conscripts. , 1990, Scandinavian journal of social medicine.

[100]  M. Timonen,et al.  Regular daily smoking among 14-year-old adolescents increases the subsequent risk for suicide: the Northern Finland 1966 Birth Cohort Study. , 2007, The Journal of clinical psychiatry.

[101]  G. Dunn,et al.  Death by homicide, suicide, and other unnatural causes in people with mental illness: a population-based study , 2001, The Lancet.