High-sensitivity attenuated total internal reflection continuous-wave terahertz imaging

We demonstrate an attenuated total internal reflection imaging system. The surface information of the sample on top of a prism can be acquired by two-dimensionally scanning this prism moving in the vertical plane with horizontally incident continuous terahertz waves at a fixed height. The principles and feasibility of this method are investigated. The effective imaging area on the prism, image resolution and polarization dependence of contrast enhancement and stability improvement are analyzed. Examples including solid agar, distilled water and porcine tissue are presented, demonstrating the method's advantages of high sensitivity and simple sample preparation. The experimental and theoretical results consistently show that p-polarization contributes to enhanced image contrast and more stable intensity of the attenuated total internal reflected signal.

[1]  Naoshi Kondo,et al.  Hydration state inside HeLa cell monolayer investigated with terahertz spectroscopy , 2015 .

[2]  Emma Pickwell-MacPherson,et al.  Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry , 2016 .

[3]  S. Kazarian,et al.  Attenuated total reflection Fourier-transform infrared (ATR-FTIR) imaging of tissues and live cells. , 2016, Chemical Society reviews.

[5]  K. Kawase,et al.  Non-destructive drug inspection in covering materials using a terahertz spectral imaging system with injection-seeded terahertz parametric generation and detection. , 2016, Optics express.

[6]  S. Kazarian,et al.  New Opportunities in Micro- and Macro-Attenuated Total Reflection Infrared Spectroscopic Imaging: Spatial Resolution and Sampling Versatility , 2003, Applied spectroscopy.

[7]  Naoshi Kondo,et al.  A quantitative study for determination of sugar concentration using attenuated total reflectance terahertz (ATR-THz) spectroscopy , 2011, Defense + Commercial Sensing.

[8]  Norbert Palka,et al.  Characterization of prospective explosive materials using terahertz time-domain spectroscopy. , 2016, Applied optics.

[9]  Traian Dascalu,et al.  In vitro human serum albumin glycation monitored by Terahertz spectroscopy , 2015 .

[10]  S. Kazarian,et al.  ATR-FTIR spectroscopic imaging to study the drying and dissolution of pharmaceutical polymer-based films. , 2016, International journal of pharmaceutics.

[11]  M. Milosevic,et al.  Internal Reflection and ATR Spectroscopy: Milosovic/Internal Reflection , 2012 .

[12]  M. Koch,et al.  THz ATR Spectroscopy for Inline Monitoring of Highly Absorbing Liquids , 2016 .

[13]  Ke Yang,et al.  Biomedical Applications of Terahertz Spectroscopy and Imaging. , 2016, Trends in biotechnology.

[14]  Martin Koch,et al.  Attenuated Total Reflection Terahertz Time-Domain Spectroscopy: Uncertainty Analysis and Reduction Scheme , 2016, IEEE Transactions on Terahertz Science and Technology.

[15]  Sang-Hoon Kim,et al.  Feasibility of terahertz reflectometry for discrimination of human early gastric cancers. , 2015, Biomedical optics express.

[16]  B. Knyazev,et al.  Obtaining spectrally selective images of objects in attenuated total reflection regime in real time in visible and terahertz ranges , 2010 .

[17]  Antoine Wojdyla,et al.  Attenuated internal reflection terahertz imaging. , 2013, Optics letters.

[18]  Hiromasa Ito,et al.  Study of water concentration measurement in thin tissues with terahertz-wave parametric source. , 2010, Optics express.

[19]  M. Hiramatsu,et al.  Evaluation of drug crystallinity in aqueous suspension using terahertz time-domain attenuated total reflection spectroscopy. , 2013, Journal of pharmaceutical sciences.