Nephrotic Syndrome Associated with Agnogenic Myeloid Metaplasia

Extramedullary hematopoiesis being an important feature of agnogenic myeloid metaplasia (AMM), a chronic myeloproliferative disease of clonal origin, may affect the kidneys, but this condition is usually asymptomatic. Until now, there is only one reported case of nephrotic syndrome associated with AMM. We present a patient with AMM who had nephrotic syndrome and whose renal biopsy revealed membranous glomerulonephritis together with renal extramedullary hematopoiesis.

[1]  K. Lehmann,et al.  Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys. , 1999, Clinical nephrology.

[2]  M. Polenaković.  [Membranous glomerulonephritis]. , 1996, Srpski arhiv za celokupno lekarstvo.

[3]  M. Jarmulowicz,et al.  Extramedullary haematopoeisis in the renal parenchyma as a cause of acute renal failure in myelofibrosis. , 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[4]  S. Chevillard,et al.  Transforming growth factor‐β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis , 1994, British journal of haematology.

[5]  M. Perazella,et al.  Nephrotic syndrome associated with agnogenic myeloid metaplasia. , 1994, American journal of nephrology.

[6]  J. Oesterling,et al.  Idiopathic myelofibrosis with myeloid metaplasia involving the renal pelves, ureters and bladder. , 1992, The Journal of urology.

[7]  O. Katoh,et al.  Effects of platelet derived growth factor, epidermal growth factor and transforming growth factor‐β on the growth of human marrow fibroblasts , 1988, British journal of haematology.

[8]  C. Nathan,et al.  Secretory products of macrophages. , 1987, The Journal of clinical investigation.

[9]  G. Striker,et al.  Glomerular lesions in lymphomas and leukemias. , 1986, The American journal of medicine.

[10]  M. S. Tobin,et al.  Mechanism of extramedullary haematopoiesis in rabbits with saponin‐induced myelofibrosis and myeloid metaplasia , 1982, British journal of haematology.

[11]  J. Richardson,et al.  Myelofibrosis , 1952, Proceedings of the Royal Society of Medicine.

[12]  R. Leblay,et al.  [Renal lesions in myelofibrosis (author's transl)]. , 1979, La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.

[13]  R. S. Francis,et al.  Renal abnormalities in agnogenic myeloid metaplasia. , 1976, Radiology.

[14]  Glew Rh,et al.  Myeloid metaplasia with myelofibrosis. The clinical spectrum of extramedullary hematopoiesis and tumor formation. , 1973 .

[15]  R. Glew,et al.  Myeloid metaplasia with myelofibrosis. The clinical spectrum of extramedullary hematopoiesis and tumor formation. , 1973, The Johns Hopkins medical journal.

[16]  M. Block,et al.  The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. , 1971, Medicine.