Epidermal necrolysis: characterization of different phenotypes using an unsupervised clustering analysis

knowledge, this is the largest multicentre evaluation of newly proposed diagnostic criteria, Delphi and PARACELSUS, for ulcerative PG. Though it may be tempting to rely on histopathology, evaluating differential diagnoses, erythematous/violaceous border, irregular shape, associated systemic diseases and response to immunosuppressants may be the most critical clues for differentiating PG from its mimickers. Skin biopsy risks exacerbating disease, but histopathology can be informative when clinical features are not definitive. Though further prospective studies are warranted to investigate the role of novel diagnostic criteria and histopathology, our study concurs with a previous study that PARACELSUS might outperform Delphi in a real-world setting.