Other high-risk conditions.

1. History of Coronary Artery Disease (CAD) Epidemiological studies and interventional trials conducted in Western countries and the results of a meta-analysis of these studies have revealed that the incidence of cardiovascular events in patients with a history of CAD is higher than that observed in primary prevention patients. In Japan, the incidence of cardiovascular events in primary prevention subjects in the J-LIT trial was 0.9/1,000 person-years, while that in secondary prevention patients was higher, with a value of 4.5/1,000 person-years. The JCAD and CREDO-Kyoto, registration studies of patients with CAD, reported the incidence of cardiovascular events to be ≥15/1,000 person-years. Among secondary prevention patients, there are further high-risk conditions, including acute coronary syndrome, smoking, diabetes mellitus, metabolic syndrome, chronic kidney disease, noncardiogenic cerebral infarction, peripheral artery disease and a constellation of risk factors. It has been reported that these patients clearly have a high incidence of recurrent coronary events, even when the LDL cholesterol (LDL-C) level is managed to the same extent as that in patients without complications.

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