Intramolecular acylation of 3‐oxo‐2‐piperidine‐propionic acid derivatives. Synthesis of hexahydro‐2‐oxopyrano[3,2‐b]pyridines

The intramolecular acylation of some δ-keto acids derived from 3-oxo-2-piperidinepropionic acid are described. Bicyclic enol lactones coming from an O-acylation reaction are obtained in all cases. The regioselec-tivity of these processes is discussed in terms of the acylating agent and the δ-keto acid structure. The procedure establishes a convenient synthesis of hexahydro-2-oxopyrano[3,2-b)pyridines.

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