Ghostbursting: the effects of dendrites on spike patterns

Abstract We present a two-compartment model of a pyramidal cell from the electrosensory lateral line lobe of weakly electric fish. These cells undergo a complex form of bursting, previously labeled “ghostbursting”, and our model reproduces many aspects of experimental recordings. We analyze the effects of varying both the conductance between the somatic and dendritic compartments in the model, and the ratio of somatic to whole-cell areas, and find that both must have moderate values for bursting to occur. This is explained in terms of the previously elucidated burst mechanism.

[1]  A Longtin,et al.  Model of gamma frequency burst discharge generated by conditional backpropagation. , 2001, Journal of neurophysiology.

[2]  J. Lisman.  Bursts as a unit of neural information: making unreliable synapses reliable , 1997, Trends in Neurosciences.

[3]  J. Bastian,et al.  Dendritic modulation of burst-like firing in sensory neurons. , 2001, Journal of neurophysiology.

[4]  Brent Doiron,et al.  Ghostbursting: A Novel Neuronal Burst Mechanism , 2004, Journal of Computational Neuroscience.

[5]  James P. Keener,et al.  Mathematical physiology , 1998 .

[6]  Bard Ermentrout,et al.  Type I Membranes, Phase Resetting Curves, and Synchrony , 1996, Neural Computation.

[7]  Gabbiani,et al.  Encoding and processing of sensory information in neuronal spike trains , 1999, The Journal of experimental biology.

[8]  T. Sejnowski,et al.  [Letters to nature] , 1996, Nature.

[9]  John Rinzel,et al.  Intrinsic and network rhythmogenesis in a reduced traub model for CA3 neurons , 1995, Journal of Computational Neuroscience.

[10]  N. Lemon,et al.  Conditional spike backpropagation generates burst discharge in a sensory neuron. , 2000, Journal of neurophysiology.

[11]  Turner,et al.  Oscillatory and burst discharge in the apteronotid electrosensory lateral line lobe , 1999, The Journal of experimental biology.

[12]  Eugene M. Izhikevich,et al.  Neural excitability, Spiking and bursting , 2000, Int. J. Bifurc. Chaos.

[13]  Xiaojing Wang,et al.  Analysis of complex bursting in cortical pyramidal neuron models , 2000, Neurocomputing.

[14]  Jianfeng Feng,et al.  Behaviour of two-compartment models , 2001, Neurocomputing.