Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist.

[1]  Stephen C Martinkovich,et al.  Selective estrogen receptor modulators: tissue specificity and clinical utility , 2014, Clinical interventions in aging.

[2]  K. McMasters,et al.  Indole-3-carbinol (I3C) increases apoptosis, represses growth of cancer cells, and enhances adenovirus-mediated oncolysis , 2014, Cancer biology & therapy.

[3]  A. Wu,et al.  Raloxifene Suppresses Experimental Autoimmune Encephalomyelitis and NF-κB-Dependent CCL20 Expression in Reactive Astrocytes , 2014, PloS one.

[4]  Jiyong Hong,et al.  Biological evaluation of subglutinol a as a novel immunosuppressive agent for inflammation intervention. , 2014, ACS medicinal chemistry letters.

[5]  F. Naftolin,et al.  The pros and cons of plant estrogens for menopause , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[6]  H. Jarry,et al.  eview he non-estrogenic alternative for the treatment of climacteric complaints : Black ohosh ( Cimicifuga or Actaea racemosa ) , 2013 .

[7]  H. Giese,et al.  Estrogenic effects of fusarielins in human breast cancer cell lines. , 2012, Toxicology letters.

[8]  H. Giese,et al.  Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro. , 2011, Toxicology letters.

[9]  S. Wardell,et al.  The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. , 2011, Biochemical pharmacology.

[10]  H. Patisaul,et al.  The pros and cons of phytoestrogens , 2010, Frontiers in Neuroendocrinology.

[11]  M. Fitzgerald,et al.  Total synthesis, assignment of the absolute stereochemistry, and structure-activity relationship studies of subglutinols A and B. , 2010, Chemistry, an Asian journal.

[12]  Yong‐Chul Kim,et al.  Stereoselective synthesis and osteogenic activity of subglutinols A and B. , 2009, Journal of the American Chemical Society.

[13]  G. Keating,et al.  Raloxifene: a review of its use in the prevention of invasive breast cancer. , 2008, Drugs.

[14]  G. Firestone,et al.  Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells. , 2006, Molecular endocrinology.

[15]  Ling-Jun Ho,et al.  Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders. , 2004, Current drug metabolism.

[16]  C. Klinge Estrogen receptor interaction with estrogen response elements. , 2001, Nucleic acids research.

[17]  Carolyn L. Smith,et al.  Molecular mechanisms of selective estrogen receptor modulator (SERM) action. , 2000, The Journal of pharmacology and experimental therapeutics.

[18]  P. Lipsky,et al.  The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. , 2000, Rheumatic diseases clinics of North America.

[19]  K. Setchell,et al.  Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. , 1998, The American journal of clinical nutrition.

[20]  M. Yanagida,et al.  Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. , 1998, Experimental cell research.

[21]  J. Clardy,et al.  Subglutinols A and B: Immunosuppressive compounds from the endophytic fungus Fusarium subglutinans , 1995 .

[22]  M. Preobrazhenskaya,et al.  Ascorbigen and other indole-derived compounds from Brassica vegetables and their analogs as anticarcinogenic and immunomodulating agents. , 1993, Pharmacology & therapeutics.