Towards a Consensus View on Understanding Nanomaterials Hazards and Managing Exposure: Knowledge Gaps and Recommendations

The aim of this article is to present an overview of salient issues of exposure, characterisation and hazard assessment of nanomaterials as they emerged from the consensus-building of experts undertaken within the four year European Commission coordination project NanoImpactNet. The approach adopted is to consolidate and condense the findings and problem-identification in such a way as to identify knowledge-gaps and generate a set of interim recommendations of use to industry, regulators, research bodies and funders. The categories of recommendation arising from the consensual view address: significant gaps in vital factual knowledge of exposure, characterisation and hazards; the development, dissemination and standardisation of appropriate laboratory protocols; address a wide range of technical issues in establishing an adequate risk assessment platform; the more efficient and coordinated gathering of basic data; greater inter-organisational cooperation; regulatory harmonization; the wider use of the life-cycle approaches; and the wider involvement of all stakeholders in the discussion and solution-finding efforts for nanosafety.

[1]  B. Worm,et al.  Global phytoplankton decline over the past century , 2010, Nature.

[2]  Peter Eaton,et al.  Gold nanoparticles for the development of clinical diagnosis methods , 2008, Analytical and bioanalytical chemistry.

[3]  Heinz Burtscher,et al.  Real-time measurement of aerosol size distributions with an electrical diffusion battery , 2002 .

[4]  이수정 해외산업간호정보 - 미국 산업안전보건연구원(National Institute for Occupational Safety and Health) 소개 , 2009 .

[5]  Laura Hodson,et al.  Report Nanoparticle metrics in the air, exposure scenarios and exposure routes , 2012 .

[6]  M Boller,et al.  Synthetic TiO2 nanoparticle emission from exterior facades into the aquatic environment. , 2008, Environmental pollution.

[7]  Arturo A Keller,et al.  Impacts of metal oxide nanoparticles on marine phytoplankton. , 2010, Environmental science & technology.

[8]  Michael Riediker,et al.  Building Expert Consensus on Uncertainty and Complexity in Nanomaterial Safety , 2011 .

[9]  Willie J.G.M. Peijnenburg,et al.  Consensus Report based on the NanoImpactNet workshop: Environmental fate and behaviour of nanoparticles - beyond listing of limitations , 2011 .

[10]  Kimberly A Prather,et al.  Recent advances in our understanding of atmospheric chemistry and climate made possible by on-line aerosol analysis instrumentation. , 2005, Analytical chemistry.

[11]  Vladimir Murashov,et al.  Essential features for proactive risk management. , 2009, Nature nanotechnology.

[12]  T. Aw,et al.  Control of substances hazardous to health. , 1989, BMJ.

[13]  Maria Dusinska,et al.  Toxicological aspects for nanomaterial in humans. , 2013, Methods in molecular biology.

[14]  M. Moore,et al.  Do nanoparticles present ecotoxicological risks for the health of the aquatic environment? , 2006, Environment international.

[15]  Arturo A. Keller,et al.  TiO2 Nanoparticles Are Phototoxic to Marine Phytoplankton , 2012, PloS one.

[16]  Michael T. Postek,et al.  Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities , 2012, Nanotoxicology.

[17]  Maria Dusinska,et al.  Nanomaterials for environmental studies: classification, reference material issues, and strategies for physico-chemical characterisation. , 2010, The Science of the total environment.

[18]  Ambient air — Determination of asbestos fibres — Indirect-transfer transmission electron microscopy method , .

[19]  Richard D. Handy,et al.  The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs , 2008, Ecotoxicology.

[20]  Albert A Koelmans,et al.  Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench , 2012, Environmental toxicology and chemistry.

[21]  Willie J.G.M. Peijnenburg,et al.  The European Network on the Health and Environmental Impact of Nanomaterials , 2011 .

[22]  Joydeep Das,et al.  Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage: Role of IκBα/NF-κB, MAPKs and mitochondrial signal , 2012, Nanotoxicology.

[23]  Steffen Foss Hansen,et al.  Environmental challenges for nanomedicine. , 2008, Nanomedicine.

[24]  Geoffrey Hunt Nanotechnoscience and complex systems: the case for nanology , 2006 .

[25]  Teresa F. Fernandes,et al.  Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far? , 2012, Ecotoxicology.

[26]  Maria Dusinska,et al.  The importance of life cycle concepts for the development of safe nanoproducts. , 2010, Toxicology.

[27]  Roland W. Scholz,et al.  Probabilistic material flow modeling for assessing the environmental exposure to compounds: Methodology and an application to engineered nano-TiO2 particles , 2010, Environ. Model. Softw..

[28]  Hilla Peretz,et al.  The , 1966 .

[29]  Delphine Bard,et al.  A Structured Observational Method to Assess Dermal Exposure to Manufactured Nanoparticles: DREAM as an Initial Assessment Tool , 2010, International journal of occupational and environmental health.

[30]  G. Kasper,et al.  Temporal evolution of nanoparticle aerosols in workplace exposure. , 2008, The Annals of occupational hygiene.

[31]  Christof Asbach,et al.  Nanoparticle exposure at nanotechnology workplaces: A review , 2011, Particle and Fibre Toxicology.

[32]  R. Aitken,et al.  Assessing exposure to airborne nanomaterials: Current abilities and future requirements , 2007 .

[33]  Markus Berges,et al.  Strategies for Assessing Occupational Health Effects of Engineered Nanomaterials , 2010 .

[34]  B. Nowack,et al.  Exposure modeling of engineered nanoparticles in the environment. , 2008, Environmental science & technology.

[35]  Hugh J. Byrne,et al.  First approaches to standard protocols and reference materials for the assessment of potential hazards associated with nanomaterials , 2009 .

[36]  Jamie R Lead,et al.  Nanomaterials in the environment: Behavior, fate, bioavailability, and effects , 2008, Environmental toxicology and chemistry.

[37]  Iseult Lynch,et al.  Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices , 2011, Nanotoxicology.

[38]  K. Hungerbühler,et al.  Estimation of cumulative aquatic exposure and risk due to silver: contribution of nano-functionalized plastics and textiles. , 2008, The Science of the total environment.

[39]  Massimo Bovenzi,et al.  Nanoparticle dermal absorption and toxicity: a review of the literature , 2009, International archives of occupational and environmental health.

[40]  Kenneth A. Dawson,et al.  The need for in situ characterisation in nanosafety assessment: funded transnational access via the QNano research infrastructure , 2012, Nanotoxicology.

[41]  Dirk Dahmann,et al.  Comparison of four mobility particle sizers with different time resolution for stationary exposure measurements , 2009 .

[42]  R. Hamel,et al.  Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: Need for multiparametric evaluation due to adsorption artifacts , 2009, Inhalation toxicology.

[43]  Thierry Meyer,et al.  Management of nanomaterials safety in research environment , 2010, Particle and Fibre Toxicology.

[44]  Laura Hodson,et al.  Harmonization of measurement strategies for exposure to manufactured nano-objects; report of a workshop. , 2012, The Annals of occupational hygiene.

[45]  Geoffrey Hunt,et al.  Building expert consensus on problems of uncertainty and complexity in nanomaterial safety , 2011 .

[46]  Derk H. Brouwer,et al.  A Road Map Toward a Globally Harmonized Approach for Occupational Health Surveillance and Epidemiology in Nanomaterial Workers , 2012, Journal of occupational and environmental medicine.

[47]  Mark Crane,et al.  Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticles , 2008, Ecotoxicology.

[48]  Dominique Lison,et al.  The nanosilica hazard: another variable entity , 2010, Particle and Fibre Toxicology.