Complications of adult spinal deformity surgery: A literature review

Purpose: Adult spinal deformity incidence increases accordingly as the population ages. Even though surgery is the best option for the treatment, the complications due to surgery are pretty challenging. This study aims to review the complication rates of adult spinal deformity surgery. Methods: A literature review of the last decade was performed searching for the query “Adult spine deformity and complication.” This search yielded 2781 results, where 79 articles were chosen to investigate the complications of adult spinal deformity surgery. In addition, the demographic data, surgical interventions, and complications were extracted from the publications. Results: A total of 26,207 patients were analyzed, and 9138 complications were found (34.5%). Implant failure, including screw loosening, breakage, distal and proximal junctional kyphosis, were the most common complications. The neurologic complications were about 10.8%, and the infection rate was 3.6%. Cardiac and pulmonary complications were about 4.8%. Discussion: Age, body mass index, smoking, osteoporosis, and other comorbidities are the significant risk factors affecting adult spinal deformity surgery. Presurgical planning and preoperative risk factor assessment must be done to avoid complications. Furthermore, intra and postoperative complications affect the patients' quality of life and length of stay, and hospital readmissions. Revision surgery also increases the risk of complications. Conclusion: Good patient evaluation before surgery and careful planning of the surgery are essential in avoiding complications of adult spinal deformity.

[1]  L. Lenke,et al.  Patient-Reported Outcomes After Complex Adult Spinal Deformity Surgery: 5-Year Results of the Scoli-Risk-1 Study , 2021, Global spine journal.

[2]  D. Ham,et al.  Validity of the global alignment proportion (GAP) score in predicting mechanical complications after adult spinal deformity surgery in elderly patients , 2021, European Spine Journal.

[3]  E. Vialle,et al.  Unplanned Readmission Following Early Postoperative Complications After Fusion Surgery in Adult Spine Deformity: A Multicentric Study , 2021, Global spine journal.

[4]  Jin-Sung Park,et al.  Who Will Require Revision Surgery Among Neurologically Intact Patients with Proximal Junctional Failure after Surgical Correction of Adult Spinal Deformity? , 2020, Spine.

[5]  O. Adogwa,et al.  Sex Differences in Postoperative Complications and Functional Status After Deformity Correction Surgery: Do Men Fare Better Than Women? , 2020, World neurosurgery.

[6]  B. Blondel,et al.  Surgical site infection following surgery for spinal deformity: About 102 patients. , 2020, Neuro-Chirurgie.

[7]  L. Lenke,et al.  Are Higher Global Alignment and Proportion Scores Associated With Increased Risks of Mechanical Complications After Adult Spinal Deformity Surgery? An External Validation , 2020, Clinical orthopaedics and related research.

[8]  Allen L. Ho,et al.  Evaluating the Impact of Spinal Osteotomy on Surgical Outcomes of Thoracolumbar Deformity Correction. , 2020, World neurosurgery.

[9]  K. Wood,et al.  Rod-Screw Constructs Composed of Dissimilar Metals Do Not Affect Complication Rates in Posterior Fusion Surgery Performed for Adult Spinal Deformity. , 2020, Clinical spine surgery.

[10]  L. Lenke,et al.  The 90-Day Reoperations and Readmissions in Complex Adult Spinal Deformity Surgery , 2020, Global spine journal.

[11]  E. Klineberg,et al.  Sarcopenia Is an Independent Risk Factor for Proximal Junctional Disease Following Adult Spinal Deformity Surgery , 2020, Global spine journal.

[12]  M. Zileli,et al.  How to Improve Outcomes of Spine Surgery in Geriatric Patients. , 2020, World neurosurgery.

[13]  D. K. Hamilton,et al.  Classifying Complications: Assessing Adult Spinal Deformity 2-Year Surgical Outcomes , 2020, Global spine journal.

[14]  Michael Chang,et al.  Adult spine deformity surgery in elderly patients: are outcomes worse in patients 75 years and older? , 2020, Spine Deformity.

[15]  L. Lenke,et al.  Partial Intraoperative Global Alignment and Proportion Scores Do Not Reliably Predict Postoperative Mechanical Failure in Adult Spinal Deformity Surgery , 2020, Global spine journal.

[16]  K. Ha,et al.  Relationship between iliac screw loosening and proximal junctional kyphosis after long thoracolumbar instrumented fusion for adult spinal deformity , 2020, European Spine Journal.

[17]  J. Vital,et al.  Multiple-rod constructs in adult spinal deformity surgery for pelvic-fixated long instrumentations: an integral matched cohort analysis , 2020, European Spine Journal.

[18]  S. Taskinen,et al.  Outcome and Complications , 2020 .

[19]  Robert K. Eastlack,et al.  Effective Prevention of Proximal Junctional Failure in Adult Spinal Deformity Surgery Requires a Combination of Surgical Implant Prophylaxis and Avoidance of Sagittal Alignment Overcorrection. , 2020, Spine.

[20]  Jin-Sung Park,et al.  Should Thoracolumbar Junction be always Avoided as Upper Instrumented Vertebra in Long Instrumented Fusion for Adult Spinal Deformity?: Risk Factor Analysis for Proximal Junctional Failure. , 2019, Spine.

[21]  F. Pellisé,et al.  Impact of resolved early major complications on 2-year follow-up outcome following adult spinal deformity surgery , 2019, European Spine Journal.

[22]  James H. Nguyen,et al.  Low rates of complications after spinopelvic fixation with iliac screws in 260 adult patients with a minimum 2-year follow-up. , 2019, Journal of neurosurgery. Spine.

[23]  D. Togawa,et al.  Multi-Rod Constructs Can Increase the Incidence of Iliac Screw Loosening after Surgery for Adult Spinal Deformity , 2019, Asian spine journal.

[24]  Munish C. Gupta,et al.  Recurrent Proximal Junctional Kyphosis: Incidence, Risk Factors, Revision Rates and Outcomes at 2 year minimum follow up. , 2019, Spine.

[25]  Osahiko Tsuji,et al.  Predictive model for major complications 2 years after corrective spine surgery for adult spinal deformity , 2018, European Spine Journal.

[26]  L. Lenke,et al.  Non-neurologic adverse events after complex adult spinal deformity surgery: results from the prospective, multicenter Scoli-RISK-1 study , 2018, European Spine Journal.

[27]  M. Abd-El-Barr,et al.  Impact of frailty on complications in patients with thoracic and thoracolumbar spinal fracture , 2018, Clinical Neurology and Neurosurgery.

[28]  R. Yassari,et al.  Risk Factors for 30-Day Readmissions and Reoperations After 3-Column Osteotomy for Spinal Deformity , 2018, Global spine journal.

[29]  Sang-Ho Lee,et al.  Minimally Invasive Spinal Surgery for Adult Spinal Deformity , 2018, Neurospine.

[30]  S. Burch,et al.  Comparative analysis of 3 surgical strategies for adult spinal deformity with mild to moderate sagittal imbalance. , 2018, Journal of neurosurgery. Spine.

[31]  Joseph S. Cheng,et al.  Association between baseline cognitive impairment and postoperative delirium in elderly patients undergoing surgery for adult spinal deformity. , 2018, Journal of neurosurgery. Spine.

[32]  V. Patel,et al.  Different types of mechanical complications after surgical correction of adult spine deformity with osteotomy , 2017 .

[33]  Robert K. Eastlack,et al.  Complication rates associated with open versus percutaneous pedicle screw instrumentation among patients undergoing minimally invasive interbody fusion for adult spinal deformity. , 2017, Neurosurgical focus.

[34]  Joseph S. Cheng,et al.  Depression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery. , 2017, Journal of neurosurgery. Spine.

[35]  Jun S. Kim,et al.  Early Complications and Outcomes in Adult Spinal Deformity Surgery: An NSQIP Study Based on 5803 Patients , 2017, Global spine journal.

[36]  Ji Yong Kim,et al.  Risk Factors of Proximal Junctional Kyphosis after Multilevel Fusion Surgery: More Than 2 Years Follow-Up Data , 2017, Journal of Korean Neurosurgical Society.

[37]  Justin K Scheer,et al.  Complication rates associated with 3-column osteotomy in 82 adult spinal deformity patients: retrospective review of a prospectively collected multicenter consecutive series with 2-year follow-up. , 2017, Journal of neurosurgery. Spine.

[38]  Munish C. Gupta,et al.  Medical Complications After Adult Spinal Deformity Surgery: Incidence, Risk Factors, and Clinical Impact , 2016, Spine.

[39]  Timothy R. Smith,et al.  Spinal Implant Density and Postoperative Lumbar Lordosis as Predictors for the Development of Proximal Junctional Kyphosis in Adult Spinal Deformity. , 2016, World neurosurgery.

[40]  D. K. Hamilton,et al.  Hospital Readmission Within 2 Years Following Adult Thoracolumbar Spinal Deformity Surgery: Prevalence, Predictors, and Effect on Patient-derived Outcome Measures , 2016, Spine.

[41]  B. Ponce,et al.  Thirty-day readmissions following adult spinal deformity surgery: an analysis of the National Surgical Quality Improvement Program (NSQIP) database. , 2016, The spine journal : official journal of the North American Spine Society.

[42]  Robert K. Eastlack,et al.  Comparison of Complications and Clinical and Radiographic Outcomes Between Nonobese and Obese Patients with Adult Spinal Deformity Undergoing Minimally Invasive Surgery. , 2016, World neurosurgery.

[43]  Justin K Scheer,et al.  Prospective multicenter assessment of perioperative and minimum 2-year postoperative complication rates associated with adult spinal deformity surgery. , 2016, Journal of neurosurgery. Spine.

[44]  D. K. Hamilton,et al.  Reoperation rates in minimally invasive, hybrid and open surgical treatment for adult spinal deformity with minimum 2-year follow-up , 2016, European Spine Journal.

[45]  Kai-Ming G. Fu,et al.  Does Minimally Invasive Percutaneous Posterior Instrumentation Reduce Risk of Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery? A Propensity-Matched Cohort Analysis. , 2016, Neurosurgery.

[46]  Viola Bullmann,et al.  Factors influencing radiographic and clinical outcomes in adult scoliosis surgery: a study of 448 European patients , 2016, European Spine Journal.

[47]  F. Luceri,et al.  Complication rate in adult deformity surgical treatment: safety of the posterior osteotomies , 2015, European Spine Journal.

[48]  Donald A. Smith,et al.  Complications and neurological deficits following minimally invasive anterior column release for adult spinal deformity: a retrospective study , 2015, European Spine Journal.

[49]  S. Berven,et al.  Three-column osteotomy surgery versus standard surgical management for the correction of adult spinal deformity: a cohort study , 2015, Journal of Orthopaedic Surgery and Research.

[50]  O. Boachie-Adjei,et al.  Complications and Unfavorable Clinical Outcomes in Obese and Overweight Patients Treated for Adult Lumbar or Thoracolumbar Scoliosis With Combined Anterior/Posterior Surgery , 2011, Journal of spinal disorders & techniques.

[51]  L. Lenke,et al.  Comparison of Standard 2-Rod Constructs to Multiple-Rod Constructs for Fixation Across 3-Column Spinal Osteotomies , 2014, Spine.

[52]  Seung-Won Park,et al.  Risk Factors for Delirium after Spine Surgery in Elderly Patients , 2014, Journal of Korean Neurosurgical Society.

[53]  Munish C. Gupta,et al.  Upper Thoracic Versus Lower Thoracic Upper Instrumented Vertebrae Endpoints Have Similar Outcomes and Complications in Adult Scoliosis , 2014, Spine.

[54]  Michael Chang,et al.  Comparative Analysis of Clinical Outcomes and Complications in Patients With Degenerative Scoliosis Undergoing Primary Versus Revision Surgery , 2014, Spine.

[55]  Zachary J. Tempel,et al.  Radiographic and clinical outcomes following combined lateral lumbar interbody fusion and posterior segmental stabilization in patients with adult degenerative scoliosis. , 2014, Neurosurgical focus.

[56]  Kai-Ming G. Fu,et al.  Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques. , 2014, Neurosurgical focus.

[57]  Munish C. Gupta,et al.  Complications and intercenter variability of three-column osteotomies for spinal deformity surgery: a retrospective review of 423 patients. , 2014, Neurosurgical focus.

[58]  L. Lenke,et al.  Patients With Proximal Junctional Kyphosis Requiring Revision Surgery Have Higher Postoperative Lumbar Lordosis and Larger Sagittal Balance Corrections , 2014, Spine.

[59]  N. Anand,et al.  Is Circumferential Minimally Invasive Surgery Effective in the Treatment of Moderate Adult Idiopathic Scoliosis? , 2014, Clinical orthopaedics and related research.

[60]  K. Khajavi,et al.  Two-year radiographic and clinical outcomes of a minimally invasive, lateral, transpsoas approach for anterior lumbar interbody fusion in the treatment of adult degenerative scoliosis , 2014, European Spine Journal.

[61]  J. Jennings,et al.  Extreme lateral interbody fusion for the treatment of adult degenerative scoliosis , 2013, Journal of Clinical Neuroscience.

[62]  S. Burch,et al.  Predictive Factors for Proximal Junctional Kyphosis in Long Fusions to the Sacrum in Adult Spinal Deformity , 2013, Spine.

[63]  Justin K Scheer,et al.  Reoperation rates and impact on outcome in a large, prospective, multicenter, adult spinal deformity database: clinical article. , 2013, Journal of neurosurgery. Spine.

[64]  Zhongqiang Chen,et al.  Complications of Correction for Focal Kyphosis After Posterior Osteotomy and the Corresponding Management , 2013, Journal of spinal disorders & techniques.

[65]  V. Deviren,et al.  Adult Degenerative Scoliosis Treated With XLIF: Clinical and Radiographical Results of a Prospective Multicenter Study With 24-Month Follow-up , 2013, Spine.

[66]  S. Boriani,et al.  Do benefits overcome the risks related to surgery for adult scoliosis? A detailed analysis of a consecutive case series , 2013, European Spine Journal.

[67]  Vedat Deviren,et al.  Proximal junctional kyphosis and clinical outcomes in adult spinal deformity surgery with fusion from the thoracic spine to the sacrum: a comparison of proximal and distal upper instrumented vertebrae. , 2013, Journal of neurosurgery. Spine.

[68]  N. Anand,et al.  Long-term 2- to 5-Year Clinical and Functional Outcomes of Minimally Invasive Surgery for Adult Scoliosis , 2013, Spine.

[69]  Samuel K. Cho,et al.  Proximal junctional kyphosis in primary adult deformity surgery: evaluation of 20 degrees as a critical angle. , 2013, Neurosurgery.

[70]  Munish C. Gupta,et al.  Incidence, Mode, and Location of Acute Proximal Junctional Failures After Surgical Treatment of Adult Spinal Deformity , 2013, Spine.

[71]  Amit Jain,et al.  Three-Column Osteotomies in the Treatment of Spinal Deformity in Adult Patients 60 Years Old and Older: Outcome and Complications , 2013, Spine.

[72]  R. Skolasky,et al.  Preliminary Results of the Effect of Prophylactic Vertebroplasty on the Incidence of Proximal Junctional Complications After Posterior Spinal Fusion to the Low Thoracic Spine , 2013, Spine deformity.

[73]  R. Crawford,et al.  Morbidity and mortality in adult spinal deformity surgery: Norwich Spinal Unit experience , 2013, European Spine Journal.

[74]  Kai-Ming G. Fu,et al.  Does prior short-segment surgery for adult scoliosis impact perioperative complication rates and clinical outcome among patients undergoing scoliosis correction? , 2012, Journal of neurosurgery. Spine.

[75]  O. Boachie-Adjei,et al.  Incidence, Risk Factors, and Natural Course of Proximal Junctional Kyphosis: Surgical Outcomes Review of Adult Idiopathic Scoliosis. Minimum 5 Years of Follow-up , 2012, Spine.

[76]  J. Buchowski,et al.  Major Complications and Comparison Between 3-Column Osteotomy Techniques in 105 Consecutive Spinal Deformity Procedures , 2012, Spine.

[77]  L. Lenke,et al.  Does a Long-Fusion “T3-Sacrum” Portend a Worse Outcome Than a Short-Fusion “T10-Sacrum” in Primary Surgery for Adult Scoliosis? , 2012, Spine.

[78]  P. Guigui,et al.  Complications and Risk Factors of Primary Adult Scoliosis Surgery: A Multicenter Study of 306 Patients , 2012, Spine.

[79]  Samuel K. Cho,et al.  Major Complications in Revision Adult Deformity Surgery: Risk Factors and Clinical Outcomes With 2- to 7-Year Follow-up , 2012, Spine.

[80]  Samuel K. Cho,et al.  Comparative Analysis of Clinical Outcome and Complications in Primary Versus Revision Adult Scoliosis Surgery , 2012, Spine.

[81]  C. Ames,et al.  Morbidity and mortality after spinal deformity surgery in patients 75 years and older: complications and predictive factors. , 2011, Journal of neurosurgery. Spine.

[82]  D. Drazin,et al.  Complications and outcomes after spinal deformity surgery in the elderly: review of the existing literature and future directions. , 2011, Neurosurgical focus.

[83]  Chuan‐feng Wang,et al.  Associations between Body Mass and the Outcome of Surgery for Scoliosis in Chinese Adults , 2011, PloS one.

[84]  O. Boachie-Adjei,et al.  Short-term Morbidity and Mortality Associated With Correction of Thoracolumbar Fixed Sagittal Plane Deformity: A Report from the Scoliosis Research Society Morbidity and Mortality Committee , 2011, Spine.

[85]  K. Bridwell,et al.  Risk-Benefit Assessment of Surgery for Adult Scoliosis: An Analysis Based on Patient Age , 2011, Spine.

[86]  O. Boachie-Adjei,et al.  Incidence, Risk Factors and Classification of Proximal Junctional Kyphosis: Surgical Outcomes Review of Adult Idiopathic Scoliosis , 2011, Spine.

[87]  V. Velanovich,et al.  Preoperative Frailty and Quality of Life as Predictors of Postoperative Complications , 2009, Annals of surgery.

[88]  S. Weinstein,et al.  Proximal junctional kyphosis in adult reconstructive spine surgery results from incomplete restoration of the lumbar lordosis relative to the magnitude of the thoracic kyphosis. , 2011, The Iowa orthopaedic journal.

[89]  O. Boachie-Adjei,et al.  138. Rates of Infection Following Spine Surgery Based on 108,419 Procedures: A Report from The Scoliosis Research Society Morbidity and Mortality Committee , 2009 .

[90]  A. Mitnitski,et al.  A comparison of two approaches to measuring frailty in elderly people. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[91]  Y. Kawaguchi,et al.  Postoperative delirium in spine surgery. , 2006, The spine journal : official journal of the North American Spine Society.