Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
暂无分享,去创建一个
Yong Chen | Sandy Chang | V. Tesmer | J. Nandakumar | Shuting Jia | Peili Gu | Taylor Takasugi | V. M. Tesmer
[1] R. DePinho,et al. Telomeres: history, health, and hallmarks of aging , 2021, Cell.
[2] M. Quadroni,et al. Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair , 2020, The EMBO journal.
[3] E. Smith,et al. Structural biology of telomeres and telomerase , 2019, Cellular and Molecular Life Sciences.
[4] T. de Lange. Shelterin-Mediated Telomere Protection. , 2018, Annual review of genetics.
[5] T. de Lange,et al. Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b , 2018, The Journal of Biological Chemistry.
[6] L. Pusztai,et al. Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer , 2017, Nature Communications.
[7] E. Skordalakes,et al. Structural and functional analysis of the human POT1-TPP1 telomeric complex , 2017, Nature Communications.
[8] M. Lei,et al. Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis , 2016, Oncogene.
[9] Ben M. Webb,et al. Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in protein science.
[10] Ben M. Webb,et al. Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in bioinformatics.
[11] Sandy Chang,et al. Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation , 2016, Aging cell.
[12] F. Setién,et al. A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families , 2015, Nature Communications.
[13] M. Zanis,et al. Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction. , 2015, Molecular biology and evolution.
[14] D. Shippen,et al. POT1a and Components of CST Engage Telomerase and Regulate Its Activity in Arabidopsis , 2014, PLoS genetics.
[15] R. Greenberg,et al. Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis , 2014, Cell.
[16] V. Quesada,et al. POT1 loss-of-function variants predispose to familial melanoma , 2014, Nature Genetics.
[17] Jianxin Shi,et al. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma , 2014, Nature Genetics.
[18] Aneela Majid,et al. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia , 2013, Nature Genetics.
[19] T. Cech,et al. Finding the end: recruitment of telomerase to telomeres , 2013, Nature Reviews Molecular Cell Biology.
[20] Leslie A. Leinwand,et al. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity , 2012, Nature.
[21] A. Venteicher,et al. TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends , 2012, Cell.
[22] T. Lange,et al. Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST , 2012, Cell.
[23] J. Lingner,et al. The human CST complex is a terminator of telomerase activity , 2012, Nature.
[24] Sandy Chang,et al. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion , 2012, The EMBO journal.
[25] Sandy Chang,et al. Essential roles for Pot1b in HSC self-renewal and survival. , 2011, Blood.
[26] T. de Lange,et al. Apollo contributes to G overhang maintenance and protects leading-end telomeres. , 2010, Molecular cell.
[27] E. Gilson,et al. SNMIB/Apollo protects leading‐strand telomeres against NHEJ‐mediated repair , 2010, The EMBO journal.
[28] J. Lingner,et al. TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo , 2010, Molecular and Cellular Biology.
[29] T. Cech,et al. Functional interaction between telomere protein TPP1 and telomerase. , 2010, Genes & development.
[30] D. Ferguson,et al. Multiple roles for Mre11 at uncapped telomeres , 2009, Nature.
[31] Wilhelm Palm,et al. Functional Dissection of Human and Mouse POT1 Proteins , 2008, Molecular and Cellular Biology.
[32] A. Multani,et al. Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR-Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis Congenita , 2008, Molecular and Cellular Biology.
[33] Richard C. Wang,et al. Engineered telomere degradation models dyskeratosis congenita. , 2008, Genes & development.
[34] R. Verdun,et al. C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins , 2008, Cell.
[35] Atsushi Miyawaki,et al. Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression , 2008, Cell.
[36] Sandy Chang,et al. Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis , 2007, The EMBO journal.
[37] T. Lange,et al. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 , 2007, Nature.
[38] Dan Liu,et al. TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase , 2007, Nature.
[39] T. Cech,et al. The POT1–TPP1 telomere complex is a telomerase processivity factor , 2007, Nature.
[40] A. Multani,et al. POT1b protects telomeres from end‐to‐end chromosomal fusions and aberrant homologous recombination , 2006, The EMBO journal.
[41] K. Collins,et al. Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. , 2006, Genes & development.
[42] T. Lange,et al. Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres , 2006, Cell.
[43] J. Deng,et al. Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres , 2006, Cell.
[44] E. Shakirov,et al. The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection , 2005, Molecular and Cellular Biology.
[45] Jun Qin,et al. PTOP interacts with POT1 and regulates its localization to telomeres , 2004, Nature Cell Biology.
[46] T. Lange,et al. POT1 as a terminal transducer of TRF1 telomere length control , 2003, Nature.
[47] P. Baumann,et al. Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans , 2001, Science.
[48] M. Goulian,et al. Purification and properties of an accessory protein for DNA polymerase alpha/primase. , 1990, The Journal of biological chemistry.
[49] R. Gibbs,et al. Germline mutations in shelterin complex genes are associated with familial glioma. , 2015, Journal of the National Cancer Institute.