Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

[1]  R. DePinho,et al.  Telomeres: history, health, and hallmarks of aging , 2021, Cell.

[2]  M. Quadroni,et al.  Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair , 2020, The EMBO journal.

[3]  E. Smith,et al.  Structural biology of telomeres and telomerase , 2019, Cellular and Molecular Life Sciences.

[4]  T. de Lange Shelterin-Mediated Telomere Protection. , 2018, Annual review of genetics.

[5]  T. de Lange,et al.  Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b , 2018, The Journal of Biological Chemistry.

[6]  L. Pusztai,et al.  Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer , 2017, Nature Communications.

[7]  E. Skordalakes,et al.  Structural and functional analysis of the human POT1-TPP1 telomeric complex , 2017, Nature Communications.

[8]  M. Lei,et al.  Human Pot1 OB-fold mutations unleash rampant telomere instability to initiate tumorigenesis , 2016, Oncogene.

[9]  Ben M. Webb,et al.  Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in protein science.

[10]  Ben M. Webb,et al.  Comparative Protein Structure Modeling Using MODELLER , 2016, Current protocols in bioinformatics.

[11]  Sandy Chang,et al.  Dysfunctional telomeres induce p53‐dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation , 2016, Aging cell.

[12]  F. Setién,et al.  A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families , 2015, Nature Communications.

[13]  M. Zanis,et al.  Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein-Protein Interaction. , 2015, Molecular biology and evolution.

[14]  D. Shippen,et al.  POT1a and Components of CST Engage Telomerase and Regulate Its Activity in Arabidopsis , 2014, PLoS genetics.

[15]  R. Greenberg,et al.  Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis , 2014, Cell.

[16]  V. Quesada,et al.  POT1 loss-of-function variants predispose to familial melanoma , 2014, Nature Genetics.

[17]  Jianxin Shi,et al.  Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma , 2014, Nature Genetics.

[18]  Aneela Majid,et al.  A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia , 2013, Nature Genetics.

[19]  T. Cech,et al.  Finding the end: recruitment of telomerase to telomeres , 2013, Nature Reviews Molecular Cell Biology.

[20]  Leslie A. Leinwand,et al.  The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity , 2012, Nature.

[21]  A. Venteicher,et al.  TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends , 2012, Cell.

[22]  T. Lange,et al.  Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST , 2012, Cell.

[23]  J. Lingner,et al.  The human CST complex is a terminator of telomerase activity , 2012, Nature.

[24]  Sandy Chang,et al.  CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion , 2012, The EMBO journal.

[25]  Sandy Chang,et al.  Essential roles for Pot1b in HSC self-renewal and survival. , 2011, Blood.

[26]  T. de Lange,et al.  Apollo contributes to G overhang maintenance and protects leading-end telomeres. , 2010, Molecular cell.

[27]  E. Gilson,et al.  SNMIB/Apollo protects leading‐strand telomeres against NHEJ‐mediated repair , 2010, The EMBO journal.

[28]  J. Lingner,et al.  TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo , 2010, Molecular and Cellular Biology.

[29]  T. Cech,et al.  Functional interaction between telomere protein TPP1 and telomerase. , 2010, Genes & development.

[30]  D. Ferguson,et al.  Multiple roles for Mre11 at uncapped telomeres , 2009, Nature.

[31]  Wilhelm Palm,et al.  Functional Dissection of Human and Mouse POT1 Proteins , 2008, Molecular and Cellular Biology.

[32]  A. Multani,et al.  Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR-Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis Congenita , 2008, Molecular and Cellular Biology.

[33]  Richard C. Wang,et al.  Engineered telomere degradation models dyskeratosis congenita. , 2008, Genes & development.

[34]  R. Verdun,et al.  C. elegans Telomeres Contain G-Strand and C-Strand Overhangs that Are Bound by Distinct Proteins , 2008, Cell.

[35]  Atsushi Miyawaki,et al.  Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression , 2008, Cell.

[36]  Sandy Chang,et al.  Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis , 2007, The EMBO journal.

[37]  T. Lange,et al.  Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 , 2007, Nature.

[38]  Dan Liu,et al.  TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase , 2007, Nature.

[39]  T. Cech,et al.  The POT1–TPP1 telomere complex is a telomerase processivity factor , 2007, Nature.

[40]  A. Multani,et al.  POT1b protects telomeres from end‐to‐end chromosomal fusions and aberrant homologous recombination , 2006, The EMBO journal.

[41]  K. Collins,et al.  Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita. , 2006, Genes & development.

[42]  T. Lange,et al.  Recent Expansion of the Telomeric Complex in Rodents: Two Distinct POT1 Proteins Protect Mouse Telomeres , 2006, Cell.

[43]  J. Deng,et al.  Pot1 Deficiency Initiates DNA Damage Checkpoint Activation and Aberrant Homologous Recombination at Telomeres , 2006, Cell.

[44]  E. Shakirov,et al.  The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection , 2005, Molecular and Cellular Biology.

[45]  Jun Qin,et al.  PTOP interacts with POT1 and regulates its localization to telomeres , 2004, Nature Cell Biology.

[46]  T. Lange,et al.  POT1 as a terminal transducer of TRF1 telomere length control , 2003, Nature.

[47]  P. Baumann,et al.  Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans , 2001, Science.

[48]  M. Goulian,et al.  Purification and properties of an accessory protein for DNA polymerase alpha/primase. , 1990, The Journal of biological chemistry.

[49]  R. Gibbs,et al.  Germline mutations in shelterin complex genes are associated with familial glioma. , 2015, Journal of the National Cancer Institute.