Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report

A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.

[1]  L. Sordillo,et al.  Peripheral markers of oxidative stress in Labrador retrievers with copper-associated hepatitis. , 2021, The Journal of small animal practice.

[2]  M. Nakaichi,et al.  Copper-associated hepatitis in a young Dalmatian dog in Japan , 2021, The Journal of veterinary medical science.

[3]  I. Nijman,et al.  Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers , 2020, Life.

[4]  H. Fieten,et al.  Evaluation of COMMD1 in copper toxicosis in Labrador retrievers and Dobermans. , 2020, Veterinary journal.

[5]  R. Leal,et al.  Canine copper-associated hepatitis: A retrospective study of 17 clinical cases , 2020, Open veterinary journal.

[6]  J. Cullen,et al.  ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs , 2019, Journal of veterinary internal medicine.

[7]  H. Fieten,et al.  Canine Copper-Associated Hepatitis. , 2017, The Veterinary clinics of North America. Small animal practice.

[8]  Matthew D Miller,et al.  Copper-associated hepatitis in a Pembroke Welsh corgi. , 2014, The Canadian veterinary journal = La revue veterinaire canadienne.

[9]  R. Else,et al.  Breed, age and gender distribution of dogs with chronic hepatitis in the United Kingdom , 2012, Veterinary journal.

[10]  A. Watson,et al.  Canine models of copper toxicosis for understanding mammalian copper metabolism , 2011, Mammalian Genome.

[11]  G. Hoffmann.  Copper-associated liver diseases. , 2009, The Veterinary clinics of North America. Small animal practice.

[12]  G. W. Knowles,et al.  Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. , 2008, Australian veterinary journal.

[13]  C. Wijmenga,et al.  Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers. , 2005, Animal genetics.

[14]  C. Webb,et al.  Copper-associated liver disease in Dalmatians: a review of 10 dogs (1998-2001). , 2002, Journal of veterinary internal medicine.

[15]  E. Breitschwerdt,et al.  Concurrent hepatic copper toxicosis and Fanconi's syndrome in a dog. , 2008, Journal of veterinary internal medicine.