Positive and negative liquid secondary ion mass spectrometry of chloro- and nitrophenylglucuronides.

Mass spectra of a series of chloro- and nitrophenylglucuronides by liquid secondary ion (LSI) mass spectrometry were obtained. In the positive ion mode class characteristic fragmentations and adduct ions are observed only in the presence of alkali salt additives. No additives were necessary in the negative ion mode to see abundant class characteristic [M-H]- and aglycone fragment ions. Cluster ion formation was found to be prominent but only in the negative ion mode.

[1]  C. Fenselau,et al.  Characterization of glucuronides with a thermospray liquid chromatography/mass spectrometry interface. , 1983, Analytical chemistry.

[2]  C. Fenselau,et al.  Analysis of glucuronides by fast atom bombardment , 1983 .

[3]  Stephen A. Martin,et al.  Optimization of experimental procedures for fast atom bombardment mass spectrometry , 1982 .

[4]  C. Fenselau,et al.  Electrophilic reactions of acyl-linked glucuronides. Formation of clofibrate mercapturate in humans. , 1982, Drug Metabolism And Disposition.

[5]  H. Schiebel,et al.  Investigations on antipyrine metabolism. II--Analysis of conjugated metabolites of antipyrine in rat and human urine by off-line combination of liquid chromatography and field desorption mass spectrometry. , 1982, Biomedical mass spectrometry.

[6]  A. Burlingame,et al.  Secondary ion mass spectrometry with cesium ion primary beam and liquid target matrix for analysis of bioorganic compounds , 1982 .

[7]  J. Bakke,et al.  Fragmentation patterns of trimethylsilyl derivatives of dihydrodiol glucuronides produced by metabolism of naphthalene and 1-methyl-N-naphthylcarbamate. , 1982, Biomedical mass spectrometry.

[8]  A. Bruins.  Negative ion desorption chemical ionization mass spectrometry of some underivatized glucuronides , 1981 .

[9]  T. Keough,et al.  Acid-enhanced field desorption mass spectrometry of zwitterions , 1981 .

[10]  D. E. Games,et al.  Combined liquid chromatography mass spectrometry of glycosides, glucuronides, sugars and nucleosides , 1980 .

[11]  C. Fenselau,et al.  Analysis of intact glucuronides by mass spectrometry and gas chromatography-mass spectrometry. A review. , 1980, Drug metabolism and disposition: the biological fate of chemicals.

[12]  C. Fenselau,et al.  The effects of heating rate and sample size on the direct exposure/chemical ionization mass spectra of some biological conjugates. , 1979, Biomedical mass spectrometry.

[13]  M. Deinzer,et al.  Characterization of glucuronide metabolites of carbamazepine in human urine by gas chromatography and mass spectrometry. , 1978, Drug metabolism and disposition: the biological fate of chemicals.

[14]  M. Deinzer,et al.  Identification of glucuronide metabolites of benzomorphan narcotic analgesic drugs in bile from the isolated perfused rat liver by gas chromatography and mass spectrometry. , 1977, Drug metabolism and disposition: the biological fate of chemicals.

[15]  H. W. Dorough.  Biological Activity of Pesticide Conjugates , 1976 .

[16]  H. Adlercreutz,et al.  Field desorption mass spectrometry in the analysis of a steroid conjugate, estriol-16alpha-glucuronide. , 1974, Journal of steroid biochemistry.

[17]  H. Schulten,et al.  High resolution field desorption mass spectrometry. II. Glycosides. , 1974, Biomedical mass spectrometry.

[18]  Paulson Gd,et al.  Characterization of aryl glucuronic acid conjugates by derivatization and mass spectral analysis. , 1973 .

[19]  S. Bernstein,et al.  Steroid conjugates. VI. An improved Koenigs-Knorr synthesis of aryl glucuronides using cadmium carbonate, a new and effective catalyst. , 1971, The Journal of organic chemistry.

[20]  重毅 田代,et al.  哺乳動物におけるpentachlorophenol (PCP)の代謝 , 1970 .

[21]  N. Bhacca,et al.  Synthesis and characterization of cholesterol beta-D-glucuronide and derivatives. , 1969, The Journal of organic chemistry.

[22]  L. J. Sullivan,et al.  Systematic approach to preparation and identification of glucuronic acid conjugates , 1967 .

[23]  J. W. Long,et al.  The Synthesis of Aryl-D-glucopyranosiduronic Acids1 , 1955 .