Jul 10, 2020 The functional role of the novel biomarker karyopherin 2

In recent years, Karyopherin a 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the translocation of several can- cer-associated proteins. We provide an overview of the clinical studies that have established the biomarker potential of KPNA2 and describe its functional role with an emphasis on established associations with cancer. Several studies linked KPNA2 to cancer. Here we present, for the first time, an overview of these reports. We describe the clinical studies which have demonstrated that KPNA2 is highly expressed in multiple cancer forms and that its aberrant expression is often tied to an adverse outcome for the patients. We also cover the studies of KPNA2 in cancer cells and present some of the can-cer-associated proteins translocated by KPNA2.

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