Ho Nam Chang Special Issue: Life of a great biochemical engineer and his life-time contribution to high cell density culture

Professor Ho Nam Chang, Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea It is my great pleasure and honor to prepare this special issue for the retirement of Professor Ho Nam Chang, a great biochemical engineer of the last decades. He has been a leader in several important areas of biochemical engineering discipline and in particular in the field of high cell density culture. His life-time work has contributed to the successful industrialization of several bioproducts such as acrylamide and commercialization of new types of fermentors (bioreactors). He has also been a leader in AsiaPacific region in promoting biochemical engineering and biotechnology by setting up the high standard of research. Even though it is not possible to describe his great contributions in this short preface, I tried my best to summarize some of his important contributions. Background

[1]  H. Chang,et al.  High cell density culture of a recombinant Escherichia coli producing penicillin acylase in a membrane cell recycle fermentor , 1990, Biotechnology and bioengineering.

[2]  H. Chang,et al.  Production of poly(3‐hydroxybutyric acid) by fed‐batch culture of Alcaligenes eutrophus with glucose concentration control , 1994, Biotechnology and bioengineering.

[3]  M. Holtzapple,et al.  Carboxylate Platform: The MixAlco Process Part 1: Comparison of Three Biomass Conversion Platforms , 2009, Applied biochemistry and biotechnology.

[4]  H. Chang,et al.  Aerobic fungal cell immobilization in a dual hollow‐fiber bioreactor: Continuous production of a citric acid , 1988, Biotechnology and bioengineering.

[5]  C L Cooney,et al.  Bioreactors: Design and Operation , 1983, Science.

[6]  H. Chang,et al.  High cell density ethanol fermentation in an upflow packed-bed cell recycle bioreactor , 2008 .

[7]  H. Chang,et al.  Variable‐volume hollow‐fiber enzyme reactor with pulsatile flow , 1983 .

[8]  H. Chang,et al.  High‐density continuous cultures of hybridoma cells in a depth filter perfusion system , 1994, Biotechnology and bioengineering.

[9]  H. Chang,et al.  Construction of plasmids, estimation of plasmid stability, and use of stable plasmids for the production of poly(3-hydroxybutyric acid) by recombinant Escherichia coli. , 1994, Journal of biotechnology.

[10]  H. Chang,et al.  Two-stage depth filter perfusion culture for recombinant antibody production by recombinant Chinese hamster ovary cell , 2008 .

[11]  H. Chang,et al.  Kinetics of ethanol fermentations in membrane cell recycle fermentors , 1987, Biotechnology and bioengineering.

[12]  H. Chang,et al.  Long-term operation of depth filter perfusion systems (DFPS) for monoclonal antibody production using recombinant CHO cells: Effect of temperature, pH, and dissolved oxygen , 2008 .

[13]  H. Chang,et al.  Inhibitory effect of carbon dioxide on the fed-batch culture of Ralstonia eutropha: evaluation by CO2 pulse injection and autogenous CO2 methods. , 2003, Biotechnology and bioengineering.

[14]  In Seok Kang,et al.  The effect of turbulence promoters on mass transfer—numerical analysis and flow visualization , 1982 .

[15]  H. Chang,et al.  High-rate continuous production of lactic acid by Lactobacillus rhamnosus in a two-stage membrane cell-recycle bioreactor. , 2001, Biotechnology and bioengineering.

[16]  Ho Nam Chang,et al.  Flow distribution in the fiber lumen side of a hollow-fiber module , 1986 .