Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis.

[1]  Yu-Wen Su,et al.  Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity , 2022, Cells.

[2]  Chuanwu Zhu,et al.  A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis. , 2022, Journal of natural products.

[3]  M. Farzaei,et al.  The Neuroprotective Role of Polydatin: Neuropharmacological Mechanisms, Molecular Targets, Therapeutic Potentials, and Clinical Perspective , 2021, Molecules.

[4]  F. Geissmann,et al.  Origins, Biology, and Diseases of Tissue Macrophages. , 2021, Annual review of immunology.

[5]  B. K. Bajaj,et al.  Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis: In vitro and in vivo bases, clinical evidence and future trends. , 2021, Pharmacological research.

[6]  Yi Liu,et al.  A narrative review of the role of the Notch signaling pathway in rheumatoid arthritis , 2021, Annals of translational medicine.

[7]  J. Ji,et al.  Therapeutic Potential of Triptolide as an Anti-Inflammatory Agent in Dextran Sulfate Sodium-Induced Murine Experimental Colitis , 2020, Frontiers in Immunology.

[8]  P. Kurre,et al.  Hematopoietic stem and progenitor cell signaling in the niche , 2020, Leukemia.

[9]  F. Staal,et al.  Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells , 2020, Cells.

[10]  Qiquan Sun,et al.  Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways , 2020, Frontiers in Immunology.

[11]  M. Zeidler,et al.  How does methotrexate work? , 2020, Biochemical Society transactions.

[12]  Jun Wang,et al.  Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling , 2020, Nature Communications.

[13]  Wei Li,et al.  Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense. , 2019, Molecular cell.

[14]  P. Gasque,et al.  Methotrexate an Old Drug with New Tricks , 2019, International journal of molecular sciences.

[15]  Wei Hou,et al.  Triptolide: Medicinal chemistry, chemical biology and clinical progress. , 2019, European journal of medicinal chemistry.

[16]  D. V. Von Hoff,et al.  Triptolide and Its Derivatives as Cancer Therapies. , 2019, Trends in pharmacological sciences.

[17]  Kailin Xu,et al.  ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP , 2019, Nature Microbiology.

[18]  Zhao‐Jun Wei,et al.  Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway. , 2019, Journal of agricultural and food chemistry.

[19]  Liang Liu,et al.  Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review. , 2018, European journal of medicinal chemistry.

[20]  D. Hume,et al.  Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. , 2018, Blood.

[21]  Xiaojuan He,et al.  The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation , 2018, International journal of molecular sciences.

[22]  U. Lendahl,et al.  Notch Signaling in Development, Tissue Homeostasis, and Disease. , 2017, Physiological reviews.

[23]  F. Anjos-Afonso,et al.  Notch Signaling in the Regulation of Hematopoietic Stem Cell , 2017, Current Stem Cell Reports.

[24]  A. Dawson,et al.  What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning? , 2017, Clinical toxicology.

[25]  C. Bombardier,et al.  Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis , 2016, British Medical Journal.

[26]  X. Chen,et al.  [Effect of triptolide on expressions of Notch receptors and ligands in rats with adjuvant- induced arthritis and reduced pulmonary function]. , 2015, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[27]  F. Rahim,et al.  The role of notch signaling in bone marrow niche , 2015, Hematology.

[28]  G. Keller,et al.  Wnt Signaling Controls the Specification of Definitive and Primitive Hematopoiesis From Human Pluripotent Stem Cells , 2014, Nature Biotechnology.

[29]  Tamara Rader,et al.  Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. , 2013, The Cochrane database of systematic reviews.

[30]  É. Jacqz-Aigrain,et al.  Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children. , 2012, Current drug metabolism.

[31]  A. Huitema,et al.  Rational administration schedule for high-dose methotrexate in patients with primary central nervous system lymphoma , 2012, Leukemia & lymphoma.

[32]  D. Link,et al.  Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice , 2011 .

[33]  M. Merad,et al.  Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche , 2011, The Journal of experimental medicine.

[34]  Youn-Jung Kim,et al.  Mechanisms underlying methotrexate-induced pulmonary toxicity , 2009, Expert opinion on drug safety.

[35]  Raphael Kopan,et al.  The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism , 2009, Cell.

[36]  D. Scott,et al.  Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years. , 2005, Rheumatology.

[37]  M. Krajinovic,et al.  Pharmacogenetics of methotrexate. , 2004, Pharmacogenomics.

[38]  C. McGlade,et al.  Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain* , 2003, Journal of Biological Chemistry.

[39]  V. Strand,et al.  Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. , 1999, Archives of internal medicine.

[40]  R. Chalmers,et al.  Methotrexate for psoriasis , 1996, Clinical and experimental dermatology.

[41]  L. Espinoza,et al.  Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis. , 1996, Arthritis and rheumatism.

[42]  J. Wolff,et al.  Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. , 1948, The New England journal of medicine.

[43]  Meilin Liu,et al.  Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. , 2019, Current drug metabolism.

[44]  D. Hume,et al.  Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. , 2017, Seminars in cell & developmental biology.

[45]  S. Fosså,et al.  Relative bioavailability of oral low dose methotrexate , 2004, European Journal of Clinical Pharmacology.

[46]  D. Miller,et al.  Acute lymphoblastic leukemia in children: current status, controversies, and future perspective. , 1983, Critical reviews in oncology/hematology.