Consensus on Treatment of Acne Scars in China (2021)

Acne scars are caused by inflammatory reactions, infections, and improper handling of acne lesions. Such scars have a high incidence and are difficult to treat. There are many methods currently used to treat acne scars, including medications, photoelectric technology, surgery, filling, chemical peeling, traditional Chinese medicine, biotherapy, and microneedle therapy, and many new methods are constantly emerging. However, there are still many issues, such as the lack of high-quality clinical studies, non-uniform treatment methods, and unsatisfactory therapeutic effects. The selection of appropriate methods for the comprehensive treatment of different types of acne scars at different stages in clinical practice remains challenging and is a research topic of great interest. From the perspective of evidence-based medicine, this consensus aims to provide a reference for the treatment of acne scars in clinical practice.

[1]  G. Fabbrocini,et al.  Skin needling for the treatment of acne scarring: a comprehensive review. , 2020, Journal of cosmetic dermatology.

[2]  J. Stiegler,et al.  Therapies for Acne Scarring , 2020 .

[3]  G. Chernoff The Utilization of a Nitric Oxide Generating Serum in the Treatment of Active Acne and Acne Scarred Patients , 2020 .

[4]  B. Katz The Fate of Active Acne and Acne Scars Following Treatment With Fractional Radiofrequency , 2019, Journal of drugs in dermatology : JDD.

[5]  H. Kwon,et al.  Atrophic acne scar: a process from altered metabolism of elastic fibres and collagen fibres based on transforming growth factor‐β1 signalling , 2019, The British journal of dermatology.

[6]  R. Mehanna,et al.  Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study , 2019, International journal of dermatology.

[7]  B. Dréno,et al.  Long-Term Effectiveness and Safety of Up to 48 Weeks’ Treatment with Topical Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in the Prevention and Reduction of Atrophic Acne Scars in Moderate and Severe Facial Acne , 2019, American Journal of Clinical Dermatology.

[8]  Nanze Yu,et al.  The Clinical Efficacy of ReCell® Autologous Cell Regeneration Techniques Combined with Dermabrasion Treatment in Acne Scars , 2019, Aesthetic Plastic Surgery.

[9]  D. Goldberg,et al.  Update on the Treatment of Scars , 2019, Journal of Drugs in Dermatology.

[10]  C. Jacob,et al.  A Review and Update of Treatment Options Using the Acne Scar Classification System , 2019, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[11]  S. Rehman,et al.  Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial. , 2019, Burns : journal of the International Society for Burn Injuries.

[12]  I. Tezcan,et al.  Tumor necrosis factor α‐308 G/A and interleukin 1 β‐511 C/T gene polymorphisms in patients with scarring acne , 2019, Journal of cosmetic dermatology.

[13]  B. Iranmanesh,et al.  Blunt cannula subcision is more effective than Nokor needle subcision for acne scars treatment , 2019, Journal of cosmetic dermatology.

[14]  C. Wambier,et al.  Basic chemical peeling-superficial and medium-depth peels. , 2019, Journal of the American Academy of Dermatology.

[15]  Aaron S Farberg,et al.  Update on acne scar treatment. , 2018, Cutis.

[16]  G. Kroumpouzos,et al.  Acne Scarring Management: Systematic Review and Evaluation of the Evidence , 2018, American Journal of Clinical Dermatology.

[17]  F. Lu,et al.  Improved Long-Term Volume Retention of Stromal Vascular Fraction Gel Grafting with Enhanced Angiogenesis and Adipogenesis , 2018, Plastic and reconstructive surgery.

[18]  R. Sivamani,et al.  Acne Scars: How Do We Grade Them? , 2018, American Journal of Clinical Dermatology.

[19]  E. Bagatin,et al.  Skin barrier and microbiome in acne , 2018, Archives of Dermatological Research.

[20]  A. Dyachenko,et al.  Optimizing Radiotherapy for Keloids: A Meta-Analysis Systematic Review Comparing Recurrence Rates Between Different Radiation Modalities , 2017, Annals of plastic surgery.

[21]  G. Kontochristopoulos,et al.  Chemical peels in active acne and acne scars. , 2017, Clinics in dermatology.

[22]  J. Leyden,et al.  Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the USA , 2017, Journal of drugs in dermatology : JDD.

[23]  Mark B. Taylor,et al.  Acne Scar Treatment: A Multimodality Approach Tailored to Scar Type , 2016, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[24]  A. Nabhan,et al.  Interventions for acne scars. , 2016, The Cochrane database of systematic reviews.

[25]  N. R. Ghaly,et al.  Autologus bone marrow stem cells in atrophic acne scars: A pilot study , 2015, The Journal of dermatological treatment.

[26]  R. Anderson,et al.  Laser treatment of traumatic scars with an emphasis on ablative fractional laser resurfacing: consensus report. , 2014, JAMA dermatology.

[27]  Evangeline B. Handog,et al.  Chemical Peels for Acne and Acne Scars in Asians: Evidence Based Review , 2012, Journal of cutaneous and aesthetic surgery.

[28]  G. Fabbrocini,et al.  Acne Scars: Pathogenesis, Classification and Treatment , 2010, Dermatology research and practice.

[29]  H. Levinson,et al.  A Review of Scar Scales and Scar Measuring Devices , 2010, Eplasty.

[30]  V. Garg,et al.  Glycolic Acid Peels Versus Salicylic–Mandelic Acid Peels in Active Acne Vulgaris and Post‐Acne Scarring and Hyperpigmentation: A Comparative Study , 2009, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[31]  Jun Li,et al.  Prevalence and risk factors of facial acne vulgaris among Chinese adolescents , 2007, International journal of adolescent medicine and health.

[32]  B. Dréno,et al.  ECCA Grading Scale: An Original Validated Acne Scar Grading Scale for Clinical Practice in Dermatology , 2006, Dermatology.

[33]  G. Goodman,et al.  Postacne Scarring: A Qualitative Global Scarring Grading System , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[34]  G. Goodman,et al.  Postacne scarring – a quantitative global scarring grading system , 2006, Journal of cosmetic dermatology.

[35]  P. V. van Zuijlen,et al.  The Patient and Observer Scar Assessment Scale: A Reliable and Feasible Tool for Scar Evaluation , 2004, Plastic and reconstructive surgery.

[36]  R. Jordan,et al.  Laser resurfacing for facial acne scars. , 2016, The Cochrane database of systematic reviews.

[37]  M. Baryza,et al.  The Vancouver Scar Scale: an administration tool and its interrater reliability. , 1995, The Journal of burn care & rehabilitation.