A new rhodamine-based chemosensor for Cu2+ and the study of its behaviour in living cells.

A new rhodamine-based chemosensor (L1) was synthesized, and it exhibits high sensitivity and selectivity for the copper cation over other commonly coexistent metal ions in aqueous solution. Upon the addition of Cu(2+), the spirolactam ring of L1 was opened and a 1 : 1 metal-ligand complex was formed. Fluorescent imaging of Cu(2+) in living cells is also successfully demonstrated.

[1]  T. Bell,et al.  Supramolecular optical chemosensors for organic analytes. , 2004, Chemical Society reviews.

[2]  E. Garcı́a-España,et al.  Preparation of Hg2+ selective fluorescent chemosensors based on surface modified core–shell aluminosilicate nanoparticles , 2010 .

[3]  Amitava Das,et al.  Resonance energy transfer approach and a new ratiometric probe for Hg2+ in aqueous media and living organism. , 2009, Organic letters.

[4]  Mi Hee Kim,et al.  Cyclams bearing diametrically disubstituted pyrenes as Cu2+- and Hg2+-selective fluoroionophores. , 2007, The Journal of organic chemistry.

[5]  Victor S-Y Lin,et al.  A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. , 2003, Journal of the American Chemical Society.

[6]  Fengjuan Chen,et al.  Dual-rhodamine urea derivative, a novel chemidosimeter for Hg(II) and its application in imaging Hg(II) in living cells , 2009, JBIC Journal of Biological Inorganic Chemistry.

[7]  Injae Shin,et al.  In vivo monitoring of mercury ions using a rhodamine-based molecular probe. , 2006, Journal of the American Chemical Society.

[8]  A. Tong,et al.  A new rhodamine-based chemosensor exhibiting selective Fe(III)-amplified fluorescence. , 2006, Organic letters.

[9]  Kwang Soo Kim,et al.  Rhodamine-based Hg2+-selective chemodosimeter in aqueous solution: fluorescent OFF-ON. , 2007, Organic letters.

[10]  A. Mathie,et al.  Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. , 2006, Pharmacology & therapeutics.

[11]  K. Rurack,et al.  A Selective and Sensitive Fluoroionophore for HgII, AgI, and CuII with Virtually Decoupled Fluorophore and Receptor Units , 2000 .

[12]  Dylan W Domaille,et al.  Synthetic fluorescent sensors for studying the cell biology of metals. , 2008, Nature chemical biology.

[13]  Colin L. Masters,et al.  Neurodegenerative diseases and oxidative stress , 2004, Nature Reviews Drug Discovery.

[14]  Fuyou Li,et al.  Multisignal chemosensor for Cr(3+) and its application in bioimaging. , 2008, Organic letters.

[15]  J. Vittal,et al.  Synthesis, characterization and physicochemical properties of copper(II) complexes containing salicylaldehyde semicarbazone , 2003 .

[16]  T. Joo,et al.  Coumarin-derived Cu(2+)-selective fluorescence sensor: synthesis, mechanisms, and applications in living cells. , 2009, Journal of the American Chemical Society.

[17]  A. Tong,et al.  New fluorescent rhodamine hydrazone chemosensor for Cu(II) with high selectivity and sensitivity. , 2006, Organic letters.

[18]  Yong Yan,et al.  Tuning the selectivity of two chemosensors to Fe(III) and Cr(III). , 2007, Organic letters.

[19]  M. Lah,et al.  Organic-inorganic hybrid nanomaterial as a new fluorescent chemosensor and adsorbent for copper ion. , 2006, Chemical communications.

[20]  H. Tian,et al.  A fluorophore capable of crossword puzzles and logic memory. , 2007, Angewandte Chemie.

[21]  J. Tae,et al.  A rhodamine-based fluorescent and colorimetric chemodosimeter for the rapid detection of Hg2+ ions in aqueous media. , 2005, Journal of the American Chemical Society.

[22]  Fuyou Li,et al.  Highly sensitive and fast responsive fluorescence turn-on chemodosimeter for Cu2+ and its application in live cell imaging. , 2008, Chemistry.

[23]  Zhaohua Dai,et al.  Ratiometric displacement approach to Cu(II) sensing by fluorescence. , 2005, Journal of the American Chemical Society.

[24]  J. Qin,et al.  An imidazole-functionalized polyacetylene: convenient synthesis and selective chemosensor for metal ions and cyanide. , 2008, Chemical communications.

[25]  B. Sarkar,et al.  Treatment of Wilson and menkes diseases. , 1999, Chemical reviews.

[26]  Juyoung Yoon,et al.  Hg2+ selective fluorescent and colorimetric sensor: its crystal structure and application to bioimaging. , 2008, Organic letters.

[27]  Yasuhiro Shiraishi,et al.  A new rhodamine-based fluorescent chemosensor for transition metal cations synthesized by one-step facile condensation , 2007 .

[28]  Shufeng Liu,et al.  Highly sensitive and selective turn-on fluorescent chemosensor for Pb2+ and Hg2+ based on a rhodamine-phenylurea conjugate. , 2010, Chemical communications.