How lymphocytes kill.

Cytotoxic T lymphocytes and natural killer cells are potent killers of target cells. These lymphocytes have large cytoplasmic granules containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated. These molecules may be directly involved in the killing of virus-infected and transformed cells as well as in the development of cell-mediated autoimmune disorders.

[1]  M. Oldstone,et al.  In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection [published erratum appears in J Exp Med 1989 Dec 1;170(6):2191] , 1989, The Journal of experimental medicine.

[2]  B. Kwon,et al.  The structure of the mouse lymphocyte pore-forming protein perforin. , 1989, Biochemical and biophysical research communications.

[3]  P. Lu,et al.  Structure and function of human perforin , 1988, Nature.

[4]  G. Berke,et al.  Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro. , 1988, Journal of immunology.

[5]  K. Stanley,et al.  A family of killer proteins , 1988, Nature.

[6]  Y. Shinkai,et al.  Homology of perforin to the ninth component of complement (C9) , 1988, Nature.

[7]  C. Frégeau,et al.  The Isolation and Characterization of a Family of Serine Protease Genes Expressed in Activated Cytotoxic T Lymphocytes , 1988, Immunological reviews.

[8]  M. A. Saper,et al.  Structure of the human class I histocompatibility antigen, HLA-A2 , 1987, Nature.

[9]  Craig W. Reynolds,et al.  Inhibition of cytolysin activity in large granular lymphocyte granules by lipids: evidence for a membrane insertion mechanism of lysis. , 1987, Molecular immunology.

[10]  J. D. Young,et al.  Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin) , 1987, The Journal of experimental medicine.

[11]  B. Bonavida,et al.  Studies on the mechanism of natural killer cell-mediated cytotoxicity. VII. functional comparison of human natural killer cytotoxic factors with recombinant lymphotoxin and tumor necrosis factor. , 1987, Journal of immunology.

[12]  C. Ware,et al.  Cytotoxic lymphokines produced by cloned human cytotoxic T lymphocytes. II. A novel CTL-produced cytotoxin that is antigenically distinct from tumor necrosis factor and alpha-lymphotoxin. , 1986, Journal of immunology.

[13]  J. D. Young,et al.  Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells , 1986, The Journal of experimental medicine.

[14]  J. Tschopp,et al.  Inhibition of the lytic activity of perforin by lipoproteins. , 1986, Journal of immunology.

[15]  Z. Cohn,et al.  Cell-mediated killing: A common mechanism? , 1986, Cell.

[16]  L. Wicker,et al.  Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice , 1986, Diabetes.

[17]  J. D. Young,et al.  The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities. , 1986, Science.

[18]  E. Podack,et al.  Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity , 1986, Cell.

[19]  R. Goldfarb.  Cell-mediated cytotoxic reactions. , 1986, Human pathology.

[20]  G. Trinchieri,et al.  Human natural killer cells: biologic and pathologic aspects. , 1984, Laboratory investigation; a journal of technical methods and pathology.

[21]  S. Singer,et al.  Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[22]  E. Podack,et al.  Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes , 1983, The Journal of experimental medicine.

[23]  K. Pyne,et al.  Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells , 1983, The Journal of experimental medicine.

[24]  Y. Tochino,et al.  Breeding of a non-obese, diabetic strain of mice. , 1980, Jikken dobutsu. Experimental animals.

[25]  E. Martz.  MULTIPLE TARGET CELL KILLING BY THE CYTOLYTIC T LYMPHOCYTE AND THE MECHANISM OF CYTOTOXICITY , 1976, Transplantation.

[26]  R. Blumenthal,et al.  Interaction of lymphocytes with lipid bilayer membranes: a model for lymphocyte-mediated lysis of target cells. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Henney.  Estimation of the size of a T-cell-induced lytic lesion , 1974, Nature.

[28]  C. Henney.  On the Mechanism of T‐Cell Mediated Cytolysis , 1973, Critical reviews in immunology.

[29]  E. Podack,et al.  Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Ritz,et al.  Lymphokine-activated killer cell activity Characteristics of effector cells and their progenitors in blood and spleen. , 1987, Immunology today.

[31]  M. Kramer,et al.  Are proteinases functional molecules of T lymphocytes? , 1987, Immunology today.

[32]  J. D. Young,et al.  Cellular and humoral mechanisms of cytotoxicity: structural and functional analogies. , 1987, Advances in immunology.

[33]  E. Podack.  Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes , 1986, Journal of cellular biochemistry.

[34]  E. Podack,et al.  Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells , 1983, Nature.

[35]  P. Henkart,et al.  Lymphocyte mediated cytolysis as a secretory phenomenon. , 1982, Advances in experimental medicine and biology.

[36]  B. Benacerraf,et al.  Interruption of the sequential release of small and large molecules from tumor cells by low temperature during cytolysis mediated by immune T-cells or complement. , 1974, Proceedings of the National Academy of Sciences of the United States of America.