Notch2 paves the way to mast cells by Hes1 and Gata3

Once regarded only as a nuisance cell that mediates allergy, mast cells (MCs) have recently gained increasing recognition as a significant regulator of the physiologic and pathologic immune response. For example, MCs not only protect the host against parasites but also play an important antibacterial role in murine models of peritonitis in which MC-deficient mice are acutely sensitive to septic shock-induced death (1, 2). Furthermore, in pathologic immune processes, MCs have been implicated in hypersensitivity and in several autoimmune diseases (3).

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