Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition.

[1]  M. Mclaughlin,et al.  Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B. , 1996, The Journal of pharmacology and experimental therapeutics.

[2]  A. Marfat,et al.  Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret. , 1996, Journal of medicinal chemistry.

[3]  M. Conti,et al.  Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. , 1995, Molecular pharmacology.

[4]  P. Hulley,et al.  Brain distribution of four rat homologues of the drosophila dunce cAMP phosphodiesterase , 1995, Journal of neuroscience research.

[5]  S. Christensen,et al.  Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site. , 1995, The Journal of pharmacology and experimental therapeutics.

[6]  M. Mclaughlin,et al.  Characterization of two human cAMP‐specific phosphodiesterase subtypes expressed in baculovirus‐infected insect cells. , 1995, Cell biology international.

[7]  M. Houslay,et al.  Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 , 1995 .

[8]  M. Ashton,et al.  Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram , 1995, British journal of pharmacology.

[9]  S. Christensen,et al.  The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity. , 1995, The Journal of pharmacology and experimental therapeutics.

[10]  J. Beattie,et al.  Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum. , 1995, The Biochemical journal.

[11]  D. Stephens,et al.  Discriminative stimulus properties of the stereoisomers of the phosphodiesterase inhibitor rolipram , 1995, Pharmacology Biochemistry and Behavior.

[12]  M. Conti,et al.  Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium. , 1995, Endocrinology.

[13]  H. Lübbert,et al.  Molecular cloning and functional expression in yeast of a human cAMP‐specific phosphodiesterase subtype (PDE IV‐C) , 1995, FEBS letters.

[14]  C. Page,et al.  Acute versus chronic administration of phosphodiesterase inhibitors on allergen‐induced pulmonary cell influx in sensitized guinea‐pigs , 1995, British journal of pharmacology.

[15]  D. Underwood,et al.  Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma. , 1994, Environmental health perspectives.

[16]  M. Houslay,et al.  Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast. , 1994, The Biochemical journal.

[17]  L. Rodgers,et al.  Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. , 1994, Gene.

[18]  G. Bolger,et al.  Molecular biology of the cyclic AMP-specific cyclic nucleotide phosphodiesterases: a diverse family of regulatory enzymes. , 1994, Cellular signalling.

[19]  J. Beavo,et al.  Multiple cyclic nucleotide phosphodiesterases. , 1994, Molecular pharmacology.

[20]  M. Houslay,et al.  Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1). , 1994, Cellular signalling.

[21]  H. Lübbert,et al.  Expression and regulation of human and rat phosphodiesterase type IV isogenes , 1994, FEBS letters.

[22]  M. Conti,et al.  The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase. , 1994, The Journal of biological chemistry.

[23]  U. Francke,et al.  Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse , 1994, Somatic cell and molecular genetics.

[24]  J. Arch,et al.  Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. , 1994, Journal of medicinal chemistry.

[25]  E. Shelton,et al.  Isolation of a cDNA encoding a human rolipram-sensitive cyclic AMP phosphodiesterase (PDE IVD). , 1994, Gene.

[26]  M. Conti,et al.  Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites. , 1994, The Journal of biological chemistry.

[27]  M. Wigler,et al.  A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs , 1993, Molecular and cellular biology.

[28]  M. Houslay,et al.  Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram. , 1993, The Biochemical journal.

[29]  M. Mclaughlin,et al.  A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. , 1993, The Journal of biological chemistry.

[30]  M. Conti,et al.  Characterization of the structure of a low Km, rolipram-sensitive cAMP phosphodiesterase. Mapping of the catalytic domain. , 1992, The Journal of biological chemistry.

[31]  M. Mclaughlin,et al.  Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast. , 1992, The Journal of biological chemistry.

[32]  M. Conti,et al.  Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. , 1991, The Journal of biological chemistry.

[33]  G. Griebel,et al.  Behavioral effects of rolipram and structurally related compounds in mice: Behavioral sedation of cAMP phosphodiesterase inhibitors , 1991, Pharmacology Biochemistry and Behavior.

[34]  J. Lowe,et al.  Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase. , 1991, Journal of medicinal chemistry.

[35]  Taylor,et al.  Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase , 1990, Molecular and cellular biology.

[36]  M. Brezinski,et al.  Stereospecific binding of the antidepressant rolipram to brain protein structures. , 1986, European journal of pharmacology.

[37]  J. Swinnen,et al.  Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4. , 1995, Cytogenetics and cell genetics.