Off-target effects and the solution

[1]  Yanpeng Wang,et al.  CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture. , 2019, Annual review of plant biology.

[2]  L. Steinmetz,et al.  Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos , 2019, Science.

[3]  Q. Gao,et al.  Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice , 2019, Science.

[4]  Jie Zhang,et al.  Whole genome sequencing reveals rare off‐target mutations and considerable inherent genetic or/and somaclonal variations in CRISPR/Cas9‐edited cotton plants , 2018, Plant biotechnology journal.

[5]  Jennifer A. Doudna,et al.  CRISPR-Cas guides the future of genetic engineering , 2018, Science.

[6]  Martin J. Aryee,et al.  In vivo CRISPR editing with no detectable genome-wide off-target mutations , 2018, Nature.

[7]  Tao Zhang,et al.  A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice , 2018, Genome Biology.

[8]  Rick L. Stevens,et al.  A communal catalogue reveals Earth’s multiscale microbial diversity , 2017, Nature.

[9]  Jian‐Kang Zhu,et al.  Precise Editing of a Target Base in the Rice Genome Using a Modified CRISPR/Cas9 System. , 2017, Molecular plant.

[10]  Rui Zhang,et al.  Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion , 2017, Nature Biotechnology.

[11]  Xingliang Ma,et al.  CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications. , 2016, Molecular plant.

[12]  David R. Liu,et al.  Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage , 2016, Nature.

[13]  Randall J. Platt,et al.  Therapeutic genome editing: prospects and challenges , 2015, Nature Medicine.

[14]  Reuben S Harris,et al.  RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. , 2002, Molecular cell.

[15]  E. Radany,et al.  Increased spontaneous mutation frequency in human cells expressing the phage PBS2-encoded inhibitor of uracil-DNA glycosylase. , 2000, Mutation research.