The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

[1]  M. Lavail,et al.  Degenerative Retinal Diseases , 2012, Springer US.

[2]  J. Seddon,et al.  Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. , 2009, Investigative ophthalmology & visual science.

[3]  U. Schlötzer-Schrehardt,et al.  Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation. , 2009, Blood.

[4]  P. Zipfel,et al.  Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H , 2009, Cell Death and Differentiation.

[5]  S. Wolf,et al.  COMPLEMENT FACTOR P IN CHOROIDAL NEOVASCULAR MEMBRANES OF PATIENTS WITH AGE-RELATED MACULAR DEGENERATION , 2009, Retina.

[6]  B. Fridley,et al.  Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration. , 2009, Investigative ophthalmology & visual science.

[7]  B. J. Klevering,et al.  The spectrum of phenotypes caused by variants in the CFH gene. , 2009, Molecular immunology.

[8]  P. Picotti,et al.  C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. , 2009, Blood.

[9]  B. Gold,et al.  Multilocus analysis of age-related macular degeneration , 2009, European Journal of Human Genetics.

[10]  C. Klaver,et al.  Complement component C3 and risk of age-related macular degeneration. , 2009, Ophthalmology.

[11]  S. Kim,et al.  Complement activation by bisretinoid constituents of RPE lipofuscin. , 2009, Investigative ophthalmology & visual science.

[12]  A. Edwards,et al.  Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects , 2009, Molecular vision.

[13]  C. Klaver,et al.  The SERPING1 gene and age-related macular degeneration , 2008, The Lancet.

[14]  S. Ennis,et al.  Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study , 2008, The Lancet.

[15]  L. Yannuzzi,et al.  Analysis of major alleles associated with age-related macular degeneration in patients with multifocal choroiditis: strong association with complement factor H. , 2008, Archives of ophthalmology.

[16]  G. Rivas,et al.  Complement Factor H Binds to Denatured Rather than to Native Pentameric C-reactive Protein* , 2008, Journal of Biological Chemistry.

[17]  P. Zipfel,et al.  Factor H family proteins and human diseases. , 2008, Trends in immunology.

[18]  Martin Oppermann,et al.  Systemic Complement Activation in Age-Related Macular Degeneration , 2008, PloS one.

[19]  Ivana K. Kim,et al.  The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration , 2008, BMC Medical Genetics.

[20]  D. Weeks,et al.  C2 and CFB Genes in Age-Related Maculopathy and Joint Action with CFH and LOC387715 Genes , 2008, PloS one.

[21]  J. Tong,et al.  Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration. , 2008, Investigative ophthalmology & visual science.

[22]  P. Garred,et al.  Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns. , 2008, Molecular immunology.

[23]  S. Rodríguez de Córdoba,et al.  Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis. , 2008, Molecular immunology.

[24]  A. Bird,et al.  Are low inflammatory reactions involved in exudative age-related macular degeneration? , 2008, Graefe's Archive for Clinical and Experimental Ophthalmology.

[25]  Eric W Klee,et al.  Data mining for biomarker development: a review of tissue specificity analysis. , 2008, Clinics in laboratory medicine.

[26]  S. D. de Córdoba,et al.  Translational Mini‐Review Series on Complement Factor H: Genetics and disease associations of human complement factor H , 2007, Clinical and experimental immunology.

[27]  W. Waegeman,et al.  Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. , 2007, Rheumatology.

[28]  G. Gilkeson,et al.  Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage. , 2007, Investigative Ophthalmology and Visual Science.

[29]  Johanna M Seddon,et al.  Variation in complement factor 3 is associated with risk of age-related macular degeneration , 2007, Nature Genetics.

[30]  Don H. Anderson,et al.  Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid. , 2007, Experimental eye research.

[31]  P. Bora,et al.  The role of complement system in ocular diseases including uveitis and macular degeneration. , 2007, Molecular immunology.

[32]  John D Lambris,et al.  The role of complement in inflammatory diseases from behind the scenes into the spotlight. , 2007, The American journal of pathology.

[33]  D. Pauleikhoff,et al.  Complement factor H variant Y402H and basal laminar deposits in exudative age-related macular degeneration , 2007, Graefe's Archive for Clinical and Experimental Ophthalmology.

[34]  I. Deary,et al.  Complement C3 variant and the risk of age-related macular degeneration. , 2007, The New England journal of medicine.

[35]  H. Rammensee,et al.  Antigen-presenting cells and the eye , 2007 .

[36]  A. Lotery,et al.  Progress in defining the molecular biology of age related macular degeneration , 2007, Human Genetics.

[37]  U. Schlötzer-Schrehardt,et al.  Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. , 2007, Molecular immunology.

[38]  Dongxu Liu,et al.  C1 inhibitor: biologic activities that are independent of protease inhibition. , 2007, Immunobiology.

[39]  R. Kawaguchi,et al.  Biochemical analysis of a common human polymorphism associated with age-related macular degeneration. , 2007, Biochemistry.

[40]  M. Bracken,et al.  Two genetic pathways for age-related macular degeneration. , 2007, Current opinion in genetics & development.

[41]  M. Pickering,et al.  Mesangial immune complex glomerulonephritis due to complement factor D deficiency. , 2007, Kidney international.

[42]  C. Curcio,et al.  Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. , 2007, Experimental eye research.

[43]  A. Blom,et al.  The Factor H Variant Associated with Age-related Macular Degeneration (His-384) and the Non-disease-associated Form Bind Differentially to C-reactive Protein, Fibromodulin, DNA, and Necrotic Cells* , 2007, Journal of Biological Chemistry.

[44]  Don H. Anderson,et al.  Y402H Polymorphism of Complement Factor H Affects Binding Affinity to C-Reactive Protein1 , 2007, The Journal of Immunology.

[45]  N. Cooper,et al.  Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line , 2007, Molecular vision.

[46]  D. Bonifati,et al.  Role of complement in neurodegeneration and neuroinflammation. , 2007, Molecular immunology.

[47]  J. Goodship,et al.  Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome , 2007, PLoS genetics.

[48]  L. Sobrin,et al.  Review of Genetics in Age Related Macular Degeneration , 2007, Seminars in ophthalmology.

[49]  M. Radeke,et al.  Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid , 2006, Proceedings of the National Academy of Sciences.

[50]  Y. Jang,et al.  Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium , 2006, Proceedings of the National Academy of Sciences.

[51]  C. Curcio,et al.  Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina. , 2006, Experimental eye research.

[52]  N. Orr,et al.  A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration , 2006, Nature Genetics.

[53]  Young H. Kwon,et al.  Retinal synthesis and deposition of complement components induced by ocular hypertension. , 2006, Experimental eye research.

[54]  Victoria A. Higman,et al.  His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form* , 2006, Journal of Biological Chemistry.

[55]  J. Handa,et al.  The expression of advanced glycation endproduct receptors in rpe cells associated with basal deposits in human maculas. , 2006, Experimental eye research.

[56]  R. T. Smith,et al.  Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration , 2006, Nature Genetics.

[57]  Alston Callahan,et al.  The role of inflammation in the pathogenesis of age-related macular degeneration. , 2006, Survey of ophthalmology.

[58]  J. Danias,et al.  Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. , 2006, Investigative ophthalmology & visual science.

[59]  Don H. Anderson,et al.  Extended haplotypes in the complement factor H (CFH) and CFH‐related (CFHR) family of genes protect against age‐related macular degeneration: Characterization, ethnic distribution and evolutionary implications , 2006, Annals of medicine.

[60]  C. Curcio,et al.  Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles. , 2005, Experimental eye research.

[61]  R. T. Smith,et al.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Joshua M Hare,et al.  Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular disease. , 2005, Trends in cardiovascular medicine.

[63]  J. Gilbert,et al.  Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration , 2005, Science.

[64]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[65]  Irving Kushner,et al.  C-reactive Protein* , 2004, Journal of Biological Chemistry.

[66]  Ronald W. Davis,et al.  SNP discovery in pooled samples with mismatch repair detection. , 2004, Genome research.

[67]  J. Cunha-Vaz.  The blood-retinal barriers system. Basic concepts and clinical evaluation. , 2004, Experimental eye research.

[68]  Richard D. Weisel,et al.  C-Reactive Protein Upregulates Complement-Inhibitory Factors in Endothelial Cells , 2004, Circulation.

[69]  N. Rifai,et al.  Association between C-reactive protein and age-related macular degeneration. , 2004, JAMA.

[70]  Alexander J. Rivest,et al.  Characterization of β amyloid assemblies in drusen: The deposits associated with aging and age-related macular degeneration , 2004 .

[71]  H. Kaplan,et al.  Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion. , 2003, Investigative ophthalmology & visual science.

[72]  A. Milam,et al.  Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. , 2003, Molecular vision.

[73]  Alexander J. Rivest,et al.  Characterization of Beta Amyloid-containing Vesicles within Drusen , 2003 .

[74]  S. Ranganathan,et al.  A common site within factor H SCR 7 responsible for binding heparin, C‐reactive protein and streptococcal M protein , 2003 .

[75]  Masaru Miyagi,et al.  Drusen proteome analysis: An approach to the etiology of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[76]  Robert F Mullins,et al.  A role for local inflammation in the formation of drusen in the aging eye. , 2002, American journal of ophthalmology.

[77]  Alexander J. Rivest,et al.  The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[78]  M. Miyagi,et al.  Clusterin is present in drusen in age-related macular degeneration. , 2002, Experimental eye research.

[79]  M. Frank,et al.  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway , 2001, The Journal of experimental medicine.

[80]  L. V. Johnson,et al.  Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. , 2001, Experimental eye research.

[81]  Robert F. Mullins,et al.  An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration , 2001, Progress in Retinal and Eye Research.

[82]  J. Laufer,et al.  Extrahepatic synthesis of complement proteins in inflammation. , 2001, Molecular immunology.

[83]  G. Hageman,et al.  Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis , 2001, Eye.

[84]  Wuding Zhou,et al.  Intrarenal synthesis of complement. , 2001, Kidney international.

[85]  D. Bok,et al.  A cell culture medium that supports the differentiation of human retinal pigment epithelium into functionally polarized monolayers. , 2001, Molecular vision.

[86]  N. Brot,et al.  C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response , 2000, The Journal of experimental medicine.

[87]  R. Würzner.  Modulation of complement membrane attack by local C7 synthesis , 2000, Clinical and experimental immunology.

[88]  S. Russell,et al.  Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[89]  L. V. Johnson,et al.  A potential role for immune complex pathogenesis in drusen formation. , 2000, Experimental eye research.

[90]  G. Hageman,et al.  Molecular composition of drusen as related to substructural phenotype. , 1999, Molecular vision.

[91]  S. Russell,et al.  Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[92]  B. Patel,et al.  Identification of Leptospira biflexa by real-time homogeneous detection of rapid cycle PCR product. , 1999, Journal of microbiological methods.

[93]  S. Horiuchi,et al.  Advanced glycation end products in age-related macular degeneration. , 1998, Archives of ophthalmology.

[94]  R. Vaughan,et al.  Contribution of renal secreted complement C3 to the circulating pool in humans. , 1998, Journal of immunology.

[95]  S. Sacks,et al.  Compartmental Localization of Complement Component Transcripts in the Normal Human Kidney , 1997, Nephron.

[96]  P. Gasque,et al.  Extrahepatic complement biosynthesis: where, when and why? , 1997, Clinical and experimental immunology.

[97]  P. Gasque,et al.  Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. , 1995, Journal of immunology.

[98]  P. Lachmann,et al.  Complement component C7. Assessment of in vivo synthesis after liver transplantation reveals that hepatocytes do not synthesize the majority of human C7. , 1994, Journal of immunology.

[99]  J. Pepose,et al.  Differential expression of the complement regulatory proteins in the human eye. , 1993, Investigative ophthalmology & visual science.

[100]  P. D. de Jong,et al.  Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study. , 1993, The British journal of ophthalmology.

[101]  Steven A. Johnson,et al.  Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental brain lesioning , 1992, Neurobiology of Aging.

[102]  B. Spiegelman,et al.  Adipsin and an endogenous pathway of complement from adipose cells. , 1992, The Journal of biological chemistry.

[103]  D. Walker,et al.  Complement gene expression in human brain: comparison between normal and Alzheimer disease cases. , 1992, Brain research. Molecular brain research.

[104]  B. Spiegelman,et al.  Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. , 1992, The Journal of biological chemistry.

[105]  D. Volkin,et al.  Complement subcomponent C1q secreted by cultured human monocytes has subunit structure identical with that of serum C1q. , 1986, The Biochemical journal.

[106]  D. Worthen,et al.  Histology of the Human Eye. , 1972 .

[107]  S. Ennis,et al.  Support for the involvement of complement factor I in age-related macular degeneration , 2010, European Journal of Human Genetics.

[108]  M. Daly,et al.  Variation near complement factor I is associated with risk of advanced AMD , 2009, European Journal of Human Genetics.

[109]  A. Edwards.  Genetics of age-related macular degeneration. , 2008, Advances in experimental medicine and biology.

[110]  H. Rammensee,et al.  Association of major histocompatibility class II antigens with core subdomains present within human ocular drusen , 2007 .

[111]  M. Pangburn,et al.  Disease-associated sequence variations in factor H: a structural biology approach. , 2006, Advances in experimental medicine and biology.

[112]  K. Whaley,et al.  Expression of the components and regulatory proteins of the alternative complement pathway and the membrane attack complex in normal and diseased synovium , 2004, Rheumatology International.

[113]  C. Curcio,et al.  Accumulation of cholesterol with age in human Bruch's membrane. , 2001, Investigative ophthalmology & visual science.

[114]  G. Hageman,et al.  Histochemical Comparison of Ocular “Drusen” in Monkey and Human , 1997 .

[115]  M. Tso,et al.  Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. , 1995, Investigative ophthalmology & visual science.

[116]  D. Bok,et al.  Peroxidase diffusion in the normal and laser-coagulated primate retina. , 1972, Investigative ophthalmology.