T2* measurements of 3-T MRI with ultrashort TEs: capabilities of pulmonary function assessment and clinical stage classification in smokers.

OBJECTIVE The purpose of this study was to determine the usefulness of MRI with ultrashort TEs on a 3-T system and of thin-section MDCT for pulmonary function assessment and clinical stage classification of chronic obstructive pulmonary disease (COPD) in smokers. SUBJECTS AND METHODS Forty smokers (24 men and 16 women; mean age ± SD, 68.0 ± 9.3 years) underwent MRI with ultrashort TEs and thin-section MDCT. Pulmonary function testing was also performed to determine the following: the ratio of forced expiratory volume in 1 second to forced vital capacity (percentage predicted) (FEV(1/)FVC%), percentage predicted forced expiratory volume in 1 second (%FEV(1)), and percentage predicted diffusing capacity of lung for carbon monoxide corrected for alveolar volume (%DLCO/V(A)). All subjects were classified into one of four groups as follows: smokers without COPD, with mild COPD, with moderate COPD, and with severe or very severe COPD. T2(*) maps were expressed using proprietary software. Regional T2(*) values were determined by region of interest measurements and were averaged to determine a mean T2(*) value for each subject. CT-based functional lung volume and the ratio of the wall area to the total airway area were also determined. All indexes were statistically correlated with pulmonary function parameters. Then, all indexes were compared among all groups by means of Tukey's honest significance test. RESULTS All indexes had significant correlation with FEV(1)/FVC%, %FEV(1), and % DLCO/V(A) (p < 0.05). All indexes except WA% of smokers without COPD and smokers with mild COPD differed significantly from those of smokers with moderate COPD and smokers with severe or very severe COPD (p < 0.05). Moreover, the mean T2(*) value of the moderate COPD group was significantly different from that of the severe or very severe COPD group (p < 0.05). CONCLUSION MRI with ultrashort TEs is potentially as useful as quantitatively assessed MDCT for pulmonary function loss assessment and clinical stage classification of COPD in smokers.

[1]  Yoshiharu Ohno,et al.  Ultrashort echo time (UTE) MRI of the lung: Assessment of tissue density in the lung parenchyma , 2010, Magnetic resonance in medicine.

[2]  Yoshiharu Ohno,et al.  Ultra‐short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice , 2010, Journal of magnetic resonance imaging : JMRI.

[3]  R. Semelka,et al.  Quantitative and qualitative comparison of 1.5 and 3.0 tesla MRI in patients with chronic liver diseases , 2009, Journal of magnetic resonance imaging : JMRI.

[4]  Jan J W Lagendijk,et al.  Ultra fast electromagnetic field computations for RF multi-transmit techniques in high field MRI , 2009, Physics in medicine and biology.

[5]  Kunihiro Yagihashi,et al.  Airway dimensions at inspiratory and expiratory multisection CT in chronic obstructive pulmonary disease: correlation with airflow limitation. , 2008, Radiology.

[6]  J. Seo,et al.  Quantitatively Assessed Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Patients With Chronic Obstructive Pulmonary Disease: Correlation of Perfusion Parameters With Pulmonary Function Test and Quantitative Computed Tomography , 2008, Investigative radiology.

[7]  Petros Martirosian,et al.  Magnetic Resonance Imaging of Lung Tissue: Influence of Body Positioning, Breathing and Oxygen Inhalation on Signal Decay Using Multi-Echo Gradient-Echo Sequences , 2008, Investigative radiology.

[8]  Y. Ohno,et al.  Oxygen-enhanced magnetic resonance imaging versus computed tomography: multicenter study for clinical stage classification of smoking-related chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.

[9]  Sumiaki Matsumoto,et al.  Dynamic oxygen-enhanced MRI versus quantitative CT: pulmonary functional loss assessment and clinical stage classification of smoking-related COPD. , 2008, AJR. American journal of roentgenology.

[10]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[11]  Bachir Taouli,et al.  Body and cardiovascular MR imaging at 3.0 T. , 2007, Radiology.

[12]  R. Lenkinski,et al.  Body MR imaging at 3.0 T: understanding the opportunities and challenges. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[13]  E. Merkle,et al.  A review of MR physics: 3T versus 1.5T. , 2007, Magnetic resonance imaging clinics of North America.

[14]  F. Korosec,et al.  Functional lung imaging using hyperpolarized gas MRI , 2007, Journal of magnetic resonance imaging : JMRI.

[15]  P. Hockings,et al.  Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single‐point imaging , 2007, Journal of magnetic resonance imaging : JMRI.

[16]  Geoffrey McLennan,et al.  State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. , 2006, Proceedings of the American Thoracic Society.

[17]  M. Hasegawa,et al.  Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. , 2006, American journal of respiratory and critical care medicine.

[18]  Brian M Dale,et al.  Abdominal MRI at 3.0 T: the basics revisited. , 2006, AJR. American journal of roentgenology.

[19]  H. Coxson,et al.  Quantitative Computed Tomography of Chronic Obstructive Pulmonary Disease1 , 2005 .

[20]  D. Altman,et al.  Applying the right statistics: analyses of measurement studies , 2003, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[21]  Hiroto Hatabu,et al.  Dynamic oxygen‐enhanced MRI reflects diffusing capacity of the lung , 2002, Magnetic resonance in medicine.

[22]  R. Pauwels,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. , 2001, Respiratory care.

[23]  J Listerud,et al.  T2* and proton density measurement of normal human lung parenchyma using submillisecond echo time gradient echo magnetic resonance imaging. , 1999, European journal of radiology.

[24]  J R MacFall,et al.  MR microscopy of the rat lung using projection reconstruction , 1993, Magnetic resonance in medicine.

[25]  A. Miller,et al.  Lung function testing: selection of reference values and interpretative strategies. , 1992, The American review of respiratory disease.

[26]  C. Durney,et al.  Alveolar air-tissue interface and nuclear magnetic resonance behavior of lung. , 1991, Journal of applied physiology.

[27]  Buist As.  Standardization of spirometry. , 1987 .

[28]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[29]  S. Matsumoto,et al.  Oxygen-enhanced MRI vs. quantitatively assessed thin-section CT: pulmonary functional loss assessment and clinical stage classification of asthmatics. , 2011, European journal of radiology.

[30]  E. Hoffman,et al.  Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment Trial. , 2006, The Journal of thoracic and cardiovascular surgery.

[31]  John P Mugler,et al.  Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. , 2002, Radiology.