Biometry of eyes in type 1 diabetes.

This is a comprehensive study of a large range of biometric and optical parameters in people with type 1 diabetes. The parameters of 74 people with type 1 diabetes and an age matched control group were assessed. Most of the people with diabetes had low levels of neuropathy, retinopathy and nephropathy. Marginal or no significant differences were found between groups for corneal shape, corneal thickness, pupil size, and pupil decentrations. Relative to the control group, the diabetes group demonstrated smaller anterior chamber depths, more curved lenses, greater lens thickness and lower lens equivalent refractive index. While the optics of diabetic eyes make them appear as older eyes than those of people of the same age without diabetes, the differences did not increase significantly with age. Age-related changes in the optics of the eyes of people with diabetes need not be accelerated if the diabetes is well controlled.

[1]  Jennifer I. Lim,et al.  Wavefront Error Correction with Adaptive Optics in Diabetic Retinopathy , 2014, Optometry and vision science : official publication of the American Academy of Optometry.

[2]  A J Bron,et al.  The lens in diabetes , 1993, Eye.

[3]  Pablo Artal,et al.  Instrument for measuring the misalignments of ocular surfaces. , 2006, Optics express.

[4]  H Saunders,et al.  AGE‐DEPENDENCE OF HUMAN REFRACTIVE ERRORS , 1981, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[5]  M. Dubbelman,et al.  The Influence of Chronic Diabetes Mellitus on the Thickness and the Shape of the Anterior and Posterior Surface of the Cornea , 2007, Cornea.

[6]  Kenji Inoue,et al.  The corneal endothelium and thickness in type II diabetes mellitus. , 2002, Japanese journal of ophthalmology.

[7]  Ankit Mathur,et al.  Amplitude of accommodation in type 1 diabetes. , 2014, Investigative ophthalmology & visual science.

[8]  Nathan Efron,et al.  Longitudinal assessment of neuropathy in type 1 diabetes using novel ophthalmic markers (LANDMark): study design and baseline characteristics. , 2014, Diabetes research and clinical practice.

[9]  M. Dubbelman,et al.  The shape of the aging human lens: curvature, equivalent refractive index and the lens paradox , 2001, Vision Research.

[10]  Arno Koning,et al.  Multiple object tracking: anticipatory attention doesn't "bounce". , 2012, Journal of vision.

[11]  B. Cho,et al.  Differences in corneal thickness and corneal endothelium related to duration in Diabetes , 2006, Eye.

[12]  Á. Hreidarsson Pupil size in insulin-dependent diabetes. Relationship to duration, metabolic control, and long-term manifestations. , 1982, Diabetes.

[13]  A. Sjølie,et al.  Long term influence of insulin dependent diabetes mellitus on refraction and its components: a population based twin study , 1997, The British journal of ophthalmology.

[14]  Ankit Mathur,et al.  Effect of Age on Components of Peripheral Ocular Aberrations , 2012, Optometry and vision science : official publication of the American Academy of Optometry.

[15]  George Smith,et al.  Chromatic dispersions of the ocular media of human eyes. , 2005, Journal of the Optical Society of America. A, Optics, image science, and vision.

[16]  T. Olsen,et al.  Clinical observations on the corneal thickness and the corneal endothelium in diabetes mellitus. , 1981, The British journal of ophthalmology.

[17]  J. Cavallerano A review of non-retinal ocular complications of diabetes mellitus. , 1990, Journal of the American Optometric Association.

[18]  Iain D Gilchrist,et al.  Oculomotor capture by transient events: a comparison of abrupt onsets, offsets, motion, and flicker. , 2008, Journal of vision.

[19]  Harold Saunders,et al.  A LONGITUDINAL STUDY OF THE AGE‐DEPENDENCE OF HUMAN OCULAR REFRACTION‐I. AGE‐DEPENDENT CHANGES IN THE EQUIVALENT SPHERE , 1986, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[20]  L. Yeung,et al.  Obtained mydriasis in long-term type 2 diabetic patients. , 2011, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[21]  George Smith,et al.  Age-related changes in optical and biometric characteristics of emmetropic eyes. , 2008, Journal of vision.

[22]  R. Klein,et al.  Accommodative ability in younger-onset diabetes. , 1987, Archives of ophthalmology.

[23]  G. Bresnick,et al.  Lenses of diabetic patients "yellow" at an accelerated rate similar to older normals. , 1991, Investigative ophthalmology & visual science.

[24]  R. West,et al.  Measurement of Refractive Errors in Young Myopes Using the COAS Shack-Hartmann Aberrometer , 2003, Optometry and vision science : official publication of the American Academy of Optometry.

[25]  C. Zetterström,et al.  The effect of phenylephrine and pilocarpine on pupil size and aqueous flare intensity in patients with diabetes mellitus. , 1998, Acta ophthalmologica Scandinavica.

[26]  Mahnaz Shahidi,et al.  Optical Section Retinal Imaging and Wavefront Sensing in Diabetes , 2004, Optometry and vision science : official publication of the American Academy of Optometry.

[27]  A. Green,et al.  Lens thickness and insulin dependent diabetes mellitus: a population based twin study. , 1996, The British journal of ophthalmology.

[28]  M. Dubbelman,et al.  The influence of diabetes mellitus type 1 and 2 on the thickness, shape, and equivalent refractive index of the human crystalline lens. , 2008, Ophthalmology.

[29]  T. Wong,et al.  Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. , 2008, Ophthalmology.

[30]  T. Wong,et al.  The relationship between anterior chamber depth and the presence of diabetes in the Tanjong Pagar Survey. , 2007, American journal of ophthalmology.

[31]  Hendrik Lehnert,et al.  Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. , 2002, Diabetes care.

[32]  D. Whitaker,et al.  Factors affecting light-adapted pupil size in normal human subjects. , 1994, Investigative ophthalmology & visual science.

[33]  Pupillary Dysfunction in Type 2 Diabetes Mellitus to Refine the Early Diagnosis of Diabetic Autonomic Neuropathy , 2006 .

[34]  H. Neil,et al.  Biometry of the crystalline lens in early-onset diabetes. , 1990, The British journal of ophthalmology.

[35]  D. Hodge,et al.  Structural and functional studies of the corneal endothelium in diabetes mellitus. , 1992, American journal of ophthalmology.

[36]  C. Creuzot-Garcher,et al.  Assessment of Induced Corneal Hypoxia In Diabetic Patients , 2002, Cornea.

[37]  E. Chew,et al.  ACCOMMODATIVE AMPLITUDES IN THE EARLY TREATMENT DIABETIC RETINOPATHY STUDY: ETDRS Report Number 21 , 1995, Retina.

[38]  J. Karakaya,et al.  Is There a Correlation Between Diabetes Mellitus and Central Corneal Thickness? , 2010, Journal of glaucoma.

[39]  Á. Hreidarsson Pupil Size in Insulin-dependent Diabetes: Relationship to Duration, Metabolic Control, and Long-Term Manifestations , 1982, Diabetes.

[40]  Juan Tabernero,et al.  Aberrations and Pupil location under corneal topography and Hartmann-Shack illumination conditions. , 2009, Investigative ophthalmology & visual science.

[41]  M. Cahill,et al.  Pupillary autonomic denervation with increasing duration of diabetes mellitus , 2001, The British journal of ophthalmology.

[42]  M. Dubbelman,et al.  Changes in the internal structure of the human crystalline lens with diabetes mellitus type 1 and type 2. , 2008, Ophthalmology.

[43]  A. Morland,et al.  Color matching in diabetes: optical density of the crystalline lens and macular pigments. , 2002, Investigative ophthalmology & visual science.

[44]  Hans C. Fledelius,et al.  Diabetic myopia ‐ is it lens‐induced? , 1987, Acta ophthalmologica.

[45]  J. Lovasik,et al.  Clinical Evaluation of Ocular and Visual Functions in Insulin‐Dependent Juvenile Diabetics , 1986, American journal of optometry and physiological optics.

[46]  R. Brubaker,et al.  Structure and function of the corneal endothelium in diabetes mellitus type I and type II. , 1996, Archives of ophthalmology.

[47]  A. Roszkowska,et al.  Corneal Endothelium Evaluation in Type I and Type II Diabetes mellitus , 1999, Ophthalmologica.