A Comparative Study for the Assessment on Blood Flow Measurement Using Self-Mixing Laser Speckle Interferometer

We study a self-mixing laser diode (SM-LD) as a low-cost compact optical sensor for noninvasive blood flow measurement over the surface of the skin. We compare the SM-LD system with a commercially available Doppler flowmeter to assess the accuracy and feasibility of the SM-LD sensors for such applications. For the SM-LD flowmeter, we apply two different signal processing methods: (1) the counting method, i.e., counting the intensity fluctuations of the signal to obtain a frequency value, and (2) the autocorrelation method, i.e., measuring the autocorrelation time of the signal. In vitro measurements show good agreement with the commercially available flowmeter. In vivo measurements performed on test subjects revealed that the autocorrelation technique shows much better results. The results of in vitro and in vivo studies and the comparison with the commercial flowmeter confirm the applicability of the SM-LD flowmeter.

[1]  Sahin Kaya Ozdemir,et al.  A speckle velocimeter using a semiconductor laser with external optical feedback from a moving surface: effects of system parameters on the reproducibility and accuracy of measurements , 2000 .

[2]  F F de Mul,et al.  Mini laser-Doppler (blood) flow monitor with diode laser source and detection integrated in the probe. , 1984, Applied optics.

[3]  Sahin Kaya Ozdemir,et al.  Compact optical instrument for surface classification using self-mixing interference in a laser diode , 2001 .

[4]  M H Koelink,et al.  Self-mixing laser-Doppler velocimetry of liquid flow and of blood perfusion in tissue. , 1992, Applied optics.

[5]  J W Pickering,et al.  In vitro double-integrating-sphere optical properties of tissues between 630 and 1064 nm , 1997, Physics in medicine and biology.

[6]  M. Stern,et al.  Laser Doppler velocimetry in blood and multiply scattering fluids: theory. , 1985, Applied optics.

[7]  R. W. Wunderlich,et al.  Laser doppler blood flow meter and optical plethysmograph , 1980 .

[8]  C. Riva,et al.  Laser Doppler measurements of blood flow in capillary tubes and retinal arteries. , 1972, Investigative ophthalmology.

[9]  K. Mito,et al.  Self-mixing effect of the semiconductor laser Doppler method for blood flow measurement , 1993, Medical and Biological Engineering and Computing.

[10]  B. Ruth,et al.  Skin blood flow evaluated by the laser speckle method and the transcutaneous oxygen tension: interpretation of the dynamics using a simple model. , 1993, International journal of microcirculation, clinical and experimental.

[11]  J. David Briers,et al.  Laser Doppler and time-varying speckle: a reconciliation , 1996 .

[12]  Satoshi Ito,et al.  Self-mixing laser speckle velocimeter for blood flow measurement , 2000, IEEE Trans. Instrum. Meas..

[13]  S. Ozdemir,et al.  Noninvasive blood flow measurement using speckle signals from a self-mixing laser diode: in vitro and in vivo experiments , 2000 .

[14]  S Shinohara,et al.  Simultaneous measurement of velocity and length of moving surfaces by a speckle velocimeter with two self-mixing laser diodes. , 1999, Applied optics.

[15]  M. Stern,et al.  In vivo evaluation of microcirculation by coherent light scattering , 1975, Nature.

[16]  R. Nossal,et al.  Model for laser Doppler measurements of blood flow in tissue. , 1981, Applied optics.

[17]  B. Ruth,et al.  Superposition of Two Dynamic Speckle Patterns , 1987 .

[18]  Toshimitsu Asakura,et al.  Bio-speckle phenomena and their application to the evaluation of blood flow , 1991 .

[19]  P Rolfe,et al.  Laser Doppler velocimetry: the problem of fibre movement artefact. , 1987, Journal of biomedical engineering.

[20]  A. K. Ozdemir,et al.  Correlation-based speckle velocimeter with self-mixing interference in a semiconductor laser diode. , 1999, Applied optics.

[21]  H. Ikeda,et al.  Laser speckle velocimeter using self-mixing laser diode , 1995, Proceedings of 1995 IEEE Instrumentation and Measurement Technology Conference - IMTC '95.

[22]  J D Briers,et al.  Capillary Blood Flow Monitoring Using Laser Speckle Contrast Analysis (LASCA). , 1999, Journal of biomedical optics.

[23]  H Fujii,et al.  Blood flow observed by time-varying laser speckle. , 1985, Optics letters.

[24]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[25]  Toshimitsu Asakura,et al.  Bio-speckle flowmetry for retinal blood flow diagnostics , 1996 .

[26]  R. Anderson,et al.  The optics of human skin. , 1981, The Journal of investigative dermatology.