Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.
暂无分享,去创建一个
[1] C. Hetz,et al. Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives , 2017, Science Signaling.
[2] J. Joyce,et al. STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation. , 2016, Cell reports.
[3] Steven J Brown,et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation , 2016, eLife.
[4] P. Walter,et al. Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress , 2016, eLife.
[5] A. Renslo,et al. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch , 2016, eLife.
[6] C. Hetz,et al. Endoplasmic Reticulum Stress and the Hallmarks of Cancer. , 2016, Trends in cancer.
[7] Helmut Kettenmann,et al. The role of microglia and macrophages in glioma maintenance and progression , 2015, Nature Neuroscience.
[8] Emily J. Girard,et al. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. , 2015, Cell reports.
[9] D. Hallahan,et al. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma , 2015, Oncotarget.
[10] P. Sapieha,et al. ER Stress and Angiogenesis. , 2015, Cell metabolism.
[11] Jen-Yang Tang,et al. Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress , 2015, Tumor Biology.
[12] Juan R. Cubillos-Ruiz,et al. ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis , 2015, Cell.
[13] C. Hetz,et al. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. , 2015, Cancer discovery.
[14] J. Diehl,et al. Tumor progression and the Different Faces of the PERK kinase , 2015, Oncogene.
[15] N. Krogan,et al. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response , 2015, eLife.
[16] Kim Schneider,et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit , 2015, Science.
[17] Wensheng Lin,et al. Pancreatic Endoplasmic Reticulum Kinase Activation Promotes Medulloblastoma Cell Migration and Invasion through Induction of Vascular Endothelial Growth Factor A , 2015, PloS one.
[18] Léo Guignard,et al. Genome‐wide screen identifies a novel p97/CDC‐48‐dependent pathway regulating ER‐stress‐induced gene transcription , 2015, EMBO reports.
[19] V. Bordignon,et al. Endoplasmic Reticulum Stress, Genome Damage, and Cancer , 2015, Front. Oncol..
[20] Anna M. McGeachy,et al. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly , 2015, eLife.
[21] J. Hesselberth,et al. The RtcB RNA ligase is an essential component of the metazoan unfolded protein response , 2014, EMBO reports.
[22] K. Caldwell,et al. RTCB-1 Mediates Neuroprotection via XBP-1 mRNA Splicing in the Unfolded Protein Response Pathway , 2014, The Journal of Neuroscience.
[23] M. Busslinger,et al. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells , 2014, The EMBO journal.
[24] R. Clarke,et al. NF-κB Signaling Is Required for XBP1 (Unspliced and Spliced)-Mediated Effects on Antiestrogen Responsiveness and Cell Fate Decisions in Breast Cancer , 2014, Molecular and Cellular Biology.
[25] W. Zong,et al. SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling. , 2014, Cancer research.
[26] A. Koong,et al. Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD , 2014, Cell reports.
[27] S. Gygi,et al. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. , 2014, Cell reports.
[28] Yan Cui,et al. The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. , 2014, Immunity.
[29] Xiaozhong Wang,et al. A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB. , 2014, Molecular cell.
[30] E. Sokol,et al. De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling , 2014, PLoS biology.
[31] Y. S. Kim,et al. Activating Transcription Factor 3-mediated Chemo-intervention with Cancer Chemokines in a Noncanonical Pathway under Endoplasmic Reticulum Stress* , 2014, The Journal of Biological Chemistry.
[32] Hongwu Zhu,et al. Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients , 2014, PloS one.
[33] Dustin J Maly,et al. Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress , 2014, Cell.
[34] C. Cubitt,et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. , 2014, The Journal of clinical investigation.
[35] G. Poda,et al. Structure and mechanism of action of the hydroxy aryl aldehyde class of IRE1 endoribonuclease inhibitors , 2014, Nature Communications.
[36] T. Fotsis,et al. VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. , 2014, Molecular cell.
[37] A. Melnick,et al. Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia , 2014, Proceedings of the National Academy of Sciences.
[38] J. Tavernier,et al. Getting RIDD of RNA: IRE1 in cell fate regulation. , 2014, Trends in biochemical sciences.
[39] E. Sokol,et al. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. , 2014, Cancer discovery.
[40] M. Ferrari,et al. XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway , 2014, Nature.
[41] R. Schekman,et al. Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6α Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance , 2014, Molecular and Cellular Biology.
[42] A. Criollo,et al. Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway , 2014, Cell.
[43] S. Ormanns,et al. Epithelial-Mesenchymal Transition Induces Endoplasmic-Reticulum-Stress Response in Human Colorectal Tumor Cells , 2014, PloS one.
[44] Y. Saeys,et al. The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells , 2014, Nature Immunology.
[45] Yongliang Zhang,et al. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. , 2014, Cancer research.
[46] S. North,et al. High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor , 2013, BMC Cancer.
[47] O. Inanami,et al. ER stress suppresses DNA double‐strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51 , 2013, FEBS letters.
[48] A. Kaser,et al. Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.
[49] H. Tilg,et al. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells , 2013, The Journal of experimental medicine.
[50] B. Clarke,et al. Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 , 2013, Clinical Cancer Research.
[51] Michael P. Schroeder,et al. IntOGen-mutations identifies cancer drivers across tumor types , 2013, Nature Methods.
[52] C. Hetz,et al. Targeting the unfolded protein response in disease , 2013, Nature Reviews Drug Discovery.
[53] Laura M. Epple,et al. Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells , 2013, PloS one.
[54] J. Sarkaria,et al. Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα. , 2013, Cancer research.
[55] L. Zitvogel,et al. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. , 2013, Immunity.
[56] C. Garlanda,et al. Tumor associated macrophages and neutrophils in tumor progression , 2013, Journal of cellular physiology.
[57] Rebecca C Taylor,et al. XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity , 2013, Cell.
[58] K. Nader,et al. Pharmacological brake-release of mRNA translation enhances cognitive memory , 2013, eLife.
[59] A. Brice,et al. ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1 , 2013, Journal of Cell Science.
[60] Lisa M. Ryno,et al. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. , 2013, Cell reports.
[61] F. Fauvet,et al. p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. , 2013, Molecular cell.
[62] Brent M. Sanders,et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. , 2013, Cancer research.
[63] S. Cohen,et al. ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation. , 2013, Genes & development.
[64] D. Ron,et al. Negative feedback by IRE1β optimizes mucin production in goblet cells , 2013, Proceedings of the National Academy of Sciences.
[65] K. Huntoon,et al. Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. , 2013, Cell reports.
[66] J. Bussink,et al. Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response , 2013, Breast Cancer Research.
[67] J. Repa,et al. The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. , 2013, The Journal of clinical investigation.
[68] M. Zanetti,et al. Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming , 2012, PloS one.
[69] A. Amon,et al. Aneuploidy causes proteotoxic stress in yeast. , 2012, Genes & development.
[70] D. Ron,et al. The ER stress transducer IRE1β is required for airway epithelial mucin production , 2012, Mucosal Immunology.
[71] Michael T. McManus,et al. IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2 , 2012, Science.
[72] F. Visioli,et al. The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. , 2012, Cancer research.
[73] M. Nieto,et al. The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. , 2012, Seminars in cancer biology.
[74] A. Papavassiliou,et al. p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress , 2012, Experimental biology and medicine.
[75] F. Saltel,et al. Autocrine control of glioma cells adhesion and migration through IRE1&agr;-mediated cleavage of SPARC mRNA , 2012, Journal of Cell Science.
[76] Dustin J Maly,et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors , 2012, Nature chemical biology.
[77] L. Shewchuk,et al. Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). , 2012, Journal of medicinal chemistry.
[78] A. Harris,et al. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress , 2012, Oncogene.
[79] P. Greengard,et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. , 2012, Cell metabolism.
[80] E. Brimble,et al. TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium. , 2012, American journal of physiology. Renal physiology.
[81] S. Iida,et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing , 2012, Blood Cancer Journal.
[82] S. Imbeaud,et al. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma , 2012, Nature Genetics.
[83] Benjamin E. Gross,et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.
[84] R. Silverman,et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule , 2012, Proceedings of the National Academy of Sciences.
[85] P. Allavena,et al. Immunology in the clinic review series; focus on cancer: tumour‐associated macrophages: undisputed stars of the inflammatory tumour microenvironment , 2012, Clinical and experimental immunology.
[86] H. Lenz,et al. Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence , 2011, Clinical Cancer Research.
[87] P. Walter,et al. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation , 2011, Science.
[88] N. Munshi,et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. , 2011, Blood.
[89] E. Chevet,et al. Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[90] K. Ye,et al. A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1α* , 2011, The Journal of Biological Chemistry.
[91] T. Blackwell,et al. Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress* , 2011, The Journal of Biological Chemistry.
[92] M. Zanetti,et al. Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells , 2011, Proceedings of the National Academy of Sciences.
[93] D. Ron,et al. Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis , 2011, Science.
[94] R. Feng,et al. Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK. , 2011, Biochemical and biophysical research communications.
[95] M. White,et al. Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction , 2011, Nature Medicine.
[96] L. Pearl,et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response , 2011, The EMBO journal.
[97] D. Durocher,et al. Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease , 2011, The Journal of Biological Chemistry.
[98] S. Nakajima,et al. Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt , 2011, Molecular and Cellular Biology.
[99] A. Koong,et al. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. , 2011, Blood.
[100] Deborah J. Andrew,et al. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity , 2010, The Journal of cell biology.
[101] V. Saudek,et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression , 2010, Proceedings of the National Academy of Sciences.
[102] M. Polymenis,et al. The Unfolded Protein Response Is Not Necessary for the G1/S Transition, but It Is Required for Chromosome Maintenance in Saccharomyces cerevisiae , 2010, PloS one.
[103] Linda M. Hendershot,et al. Transcriptional and Post-Transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response , 2010, PloS one.
[104] P. Scriven,et al. Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma , 2010, European journal of gastroenterology & hepatology.
[105] S. Schwarze,et al. IRE1α controls cyclin A1 expression and promotes cell proliferation through XBP-1 , 2010, Cell Stress and Chaperones.
[106] F. Sotgia,et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution , 2010, Cell cycle.
[107] A. von Deimling,et al. Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma , 2010, Proceedings of the National Academy of Sciences.
[108] V. Jordan,et al. Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells , 2010, Hormone molecular biology and clinical investigation.
[109] Xi Chen,et al. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages , 2010, Nature Immunology.
[110] C. Koumenis,et al. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage , 2010, Oncogene.
[111] P. Fisher,et al. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. , 2010, Cancer research.
[112] T. Ward,et al. Biogenesis of secretory organelles during B cell differentiation , 2010, Journal of leukocyte biology.
[113] Philippe Lambin,et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. , 2010, The Journal of clinical investigation.
[114] A. Harris,et al. Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia , 2009, Cell cycle.
[115] R. Huang,et al. Epithelial-Mesenchymal Transitions in Development and Disease , 2009, Cell.
[116] Robert H. Brown,et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. , 2009, Genes & development.
[117] Po-Cheng Chiang,et al. Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78 , 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.
[118] J. Weissman,et al. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells , 2009, The Journal of cell biology.
[119] Lixin Sun,et al. HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages. , 2009, Biochemical pharmacology.
[120] C. B. Pickett,et al. The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress* , 2009, Journal of Biological Chemistry.
[121] P. Allen,et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. , 2009, Cancer research.
[122] M. Jung,et al. ATM blocks tunicamycin‐induced endoplasmic reticulum stress , 2009, FEBS letters.
[123] E. Caron,et al. ER stress affects processing of MHC class I-associated peptides , 2009, BMC Immunology.
[124] D. Busam,et al. An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2008, Science.
[125] H. Tilg,et al. XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease , 2008, Cell.
[126] J. Kuratsu,et al. Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas , 2008, The Journal of pathology.
[127] J. Aguirre-Ghiso,et al. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo , 2008, Proceedings of the National Academy of Sciences.
[128] G. Hardiman,et al. KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity12 , 2008, The Journal of Immunology.
[129] Buzz Baum,et al. Transitions between epithelial and mesenchymal states in development and disease. , 2008, Seminars in cell & developmental biology.
[130] M. Imoto,et al. SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation , 2008, The Journal of Antibiotics.
[131] P. Allavena,et al. The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance , 2008, Immunological reviews.
[132] F. Beguinot,et al. ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells , 2008, Journal of Cell Science.
[133] P. Brown,et al. The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors , 2008, Oncogene.
[134] R. Clarke,et al. Human X‐Box binding protein‐1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[135] J. Aguirre-Ghiso,et al. Models, mechanisms and clinical evidence for cancer dormancy , 2007, Nature Reviews Cancer.
[136] H. Yoshida,et al. Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 , 2007 .
[137] M. Imoto,et al. Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. , 2007, The Journal of Antibiotics.
[138] R. Kaufman,et al. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. , 2007, Cancer research.
[139] Nathan H. Lents,et al. XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. , 2007, Molecular cell.
[140] P. Walter,et al. Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.
[141] A. Protopopov,et al. The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis , 2007, Cancer cell.
[142] E. Birney,et al. Patterns of somatic mutation in human cancer genomes , 2007, Nature.
[143] N. Kasabov,et al. Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer , 2007, Clinical Cancer Research.
[144] F. Urano,et al. Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress , 2006, Molecular and Cellular Biology.
[145] D. Ron,et al. Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress , 2006, Molecular and Cellular Biology.
[146] S. Gruber,et al. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway , 2006, Nature Cell Biology.
[147] V. Rybin,et al. HDAC6–p97/VCP controlled polyubiquitin chain turnover , 2006, The EMBO journal.
[148] Jonathan S Weissman,et al. Decay of Endoplasmic Reticulum-Localized mRNAs During the Unfolded Protein Response , 2006, Science.
[149] David J. Yang,et al. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. , 2006, Neuro-oncology.
[150] J. Aguirre-Ghiso,et al. Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells. , 2006, Cancer research.
[151] K. Mori,et al. Transformation‐associated gene regulation by ATF6α during hepatocarcinogenesis , 2006, FEBS letters.
[152] D. Scheuner,et al. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth , 2005, The EMBO journal.
[153] Junying Yuan,et al. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress , 2005, Science.
[154] L. Hendershot,et al. The role of the unfolded protein response in tumour development: friend or foe? , 2004, Nature Reviews Cancer.
[155] Ron Prywes,et al. Dependence of Site-2 Protease Cleavage of ATF6 on Prior Site-1 Protease Digestion Is Determined by the Size of the Luminal Domain of ATF6* , 2004, Journal of Biological Chemistry.
[156] B. Wouters,et al. Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress , 2004, Molecular and Cellular Biology.
[157] J. Alan Diehl,et al. PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress* , 2004, Journal of Biological Chemistry.
[158] P. Gaffney,et al. Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck , 2004, Cancer Research.
[159] Randal J. Kaufman,et al. Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival , 2003, Molecular and Cellular Biology.
[160] Neal N. Iwakoshi,et al. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[161] Rakesh K Jain,et al. Molecular regulation of vessel maturation , 2003, Nature Medicine.
[162] U. Grohmann,et al. Tolerance, DCs and tryptophan: much ado about IDO. , 2003, Trends in immunology.
[163] P. Allavena,et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. , 2002, Trends in immunology.
[164] Xi Chen,et al. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. , 2002, Developmental cell.
[165] Noam Brown,et al. The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies , 2002, The Journal of pathology.
[166] Hiderou Yoshida,et al. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. , 2002, Genes & development.
[167] Stevan R. Hubbard,et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA , 2002, Nature.
[168] T. Poggio,et al. Multiclass cancer diagnosis using tumor gene expression signatures , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[169] D. Ron,et al. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α , 2001, The Journal of cell biology.
[170] Judy H. Cho,et al. Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. , 2001, The Journal of clinical investigation.
[171] Alberto Mantovani,et al. Inflammation and cancer: back to Virchow? , 2001, The Lancet.
[172] T. Iwawaki,et al. Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress , 2001, Nature Cell Biology.
[173] X. Chen,et al. ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.
[174] J. W. Brewer,et al. PERK mediates cell-cycle exit during the mammalian unfolded protein response. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[175] A. Choi,et al. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. , 2000, The Journal of biological chemistry.
[176] Hiderou Yoshida,et al. ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the cis-Acting Element Responsible for the Mammalian Unfolded Protein Response , 2000, Molecular and Cellular Biology.
[177] H. Saji,et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[178] Anne Bertolotti,et al. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response , 2000, Nature Cell Biology.
[179] F. Urano,et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.
[180] K. Mori,et al. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. , 1999, Molecular biology of the cell.
[181] A. Choi,et al. Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene* , 1999, The Journal of Biological Chemistry.
[182] D. Ron,et al. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase , 1999, Nature.
[183] Xiaozhong Wang,et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.
[184] P. Walter,et al. A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response , 1996, Cell.
[185] J. Sambrook,et al. A transmembrane protein with a cdc2+ CDC28 -related kinase activity is required for signaling from the ER to the nucleus , 1993, Cell.
[186] M. Maines. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[187] J. Sambrook,et al. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins , 1988, Nature.
[188] E. Chevet,et al. Adaptation of the secretory pathway in cancer through IRE1 signaling. , 2015, Methods in molecular biology.
[189] Fangzhou Song,et al. XBP1 induces snail expression to promote epithelial- to-mesenchymal transition and invasion of breast cancer cells. , 2015, Cellular signalling.
[190] C. Hetz,et al. Control of systemic proteostasis by the nervous system. , 2015, Trends in cell biology.
[191] Heijmans. UvA-DARE ( Digital Academic Repository ) A close-up of colon cancer , 2013 .
[192] J. Teague,et al. COSMIC: the catalogue of somatic mutations in cancer , 2011, Genome Biology.
[193] A. Harada,et al. ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. , 2008, Cell structure and function.
[194] R. Deberardinis,et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. , 2008, Cell metabolism.
[195] J. Pollard. Tumour-educated macrophages promote tumour progression and metastasis , 2004, Nature Reviews Cancer.
[196] R. Sood,et al. Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 a -Subunit Kinase, PEK, Involved in Translational Control , 2022 .
[197] L. Glimcher,et al. Brief Definitive Report the Transcription Factor Xbp-1 Is Essential for the Development and Survival of Dendritic Cells , 2022 .