Laser-activated shape memory polymer intravascular thrombectomy device.

A blood clot (thrombus) that becomes lodged in the arterial network supplying the brain can cause an ischemic stroke, depriving the brain of oxygen and often resulting in permanent disability. As an alternative to conventional clot-dissolving drug treatment, we are developing an intravascular laser-activated therapeutic device using shape memory polymer (SMP) to mechanically retrieve the thrombus and restore blood flow to the brain. Thermal imaging and computer simulation were used to characterize the optical and photothermal behavior of the SMP microactuator. Deployment of the SMP device in an in vitro thrombotic vascular occlusion model demonstrated the clinical treatment concept.

[1]  Dennis L. Matthews,et al.  Mechanical Properties of Mechanical Actuator for Treating Ischemic Stroke , 2002 .

[2]  Melodie F Metzger,et al.  Photothermal properties of shape memory polymer micro‐actuators for treating stroke * , 2002, Lasers in surgery and medicine.

[3]  M. Carr,et al.  A hypothesis-generating study to evaluate platelet activity in diabetics with chronic kidney disease , 2005, Thrombosis journal.

[4]  D. Sardar,et al.  Optical Properties of Whole Blood , 1998, Lasers in Medical Science.

[5]  Fernando Vinuela,et al.  Beyond tissue plasminogen activator: mechanical intervention in acute stroke. , 2003, Annals of emergency medicine.

[6]  R. Higashida,et al.  Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled Trial , 1999 .

[7]  D. Kessel,et al.  Current trends in thrombolysis: implications for diagnostic and interventional radiology. , 2005, Clinical radiology.

[8]  T. Mayer,et al.  Treatment of Basilar Artery Embolism With a Mechanical Extraction Device: Necessity of Flow Reversal , 2002, Stroke.

[9]  A M Norbash,et al.  Rheolytic thrombectomy of the occluded internal carotid artery in the setting of acute ischemic stroke. , 2001, AJNR. American journal of neuroradiology.

[10]  C. Kerber,et al.  Snare retrieval of intracranial thrombus in patients with acute stroke. , 2002, Journal of vascular and interventional radiology : JVIR.

[11]  M. Carr,et al.  Platelet contractile force (PCF) and clot elastic modulus (CEM) are elevated in diabetic patients with chest pain , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[12]  Alexander Norbash,et al.  Mechanical Thrombolysis in Acute Ischemic Stroke With Endovascular Photoacoustic Recanalization , 2004, Stroke.

[13]  Fernando Vinuela,et al.  MERCI 1: A Phase 1 Study of Mechanical Embolus Removal in Cerebral Ischemia , 2004, Stroke.

[14]  D. Bravata.  Intravenous Thrombolysis in Acute Ischaemic Stroke , 2005, CNS drugs.

[15]  R. Higashida,et al.  PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism. , 1998, Stroke.

[16]  R. Higashida,et al.  Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke , 2001, Neurology.