Effects of Muscle Pump on Rotary Blood Pumps in Dynamic Exercise: A Computer Simulation Study

Computer simulation is an important tool to study the interaction between rotary blood pumps (RBPs) and human circulatory system. This interaction is critical for the development of reliable physiological control systems of long-term RBPs. This paper presents a numerical model of the human circulatory system, which innovatively takes the muscle pump into account in dynamic exercise. Simulation results demonstrate that the inclusion of muscle pump will change the response of hemodynamic variables and RBP parameters. These findings also show the necessity to verify the performance of RBPs and their physiological control systems in dynamic exercise with the muscle pump taken into account. By using Matlab Simulink software to simulate real-time circulatory properties, this study provides the bench-top test environment for long-term RBPs and their physiological controller.

[1]  T Tsukiya,et al.  Use of motor current in flow rate measurement for the magnetically suspended centrifugal blood pump. , 2008, Artificial organs.

[2]  H. Herrmann,et al.  Linearity of the left ventricular end-systolic pressure-volume relation in patients with severe heart failure. , 1989, Journal of the American College of Cardiology.

[3]  J. Ritchie,et al.  The effect of pulmonary hypertension on systolic function of the right ventricle. , 1983, Chest.

[4]  James F. Antaki,et al.  Control system architecture for mechanical cardiac assist devices , 2000, Proceedings of the 2000 American Control Conference. ACC (IEEE Cat. No.00CH36334).

[5]  W P Santamore,et al.  Ventricular interdependence: significant left ventricular contributions to right ventricular systolic function. , 1998, Progress in cardiovascular diseases.

[6]  Georg Wieselthaler,et al.  First clinical experience with an automatic control system for rotary blood pumps during ergometry and right-heart catheterization. , 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[7]  Tadahiko Shinshi,et al.  Magnetically Suspended Centrifugal Blood Pump With a Radial Magnetic Driver , 2005, ASAIO journal.

[8]  C. Boucher,et al.  Inotropic effect of nicardipine in patients with heart failure: assessment by left ventricular end-systolic pressure-volume analysis. , 1989, Journal of the American College of Cardiology.

[9]  K. Peterson,et al.  Diastolic Left Ventricular Pressure-Volume and Stress-Strain Relations in Patients with Valvular Aortic Stenosis and Left Ventricular Hypertrophy , 1978, Circulation.

[10]  C F Notarius,et al.  Central venous pressure during exercise: role of muscle pump. , 1996, Canadian journal of physiology and pharmacology.

[11]  F. Rademakers,et al.  Triple control of relaxation: implications in cardiac disease. , 1984, Circulation.

[12]  J D Thomas,et al.  Numeric modeling of the cardiovascular system with a left ventricular assist device. , 1999, ASAIO journal.

[13]  Mikhail Skliar,et al.  Physiological control of blood pumps using intrinsic pump parameters: a computer simulation study. , 2006, Artificial organs.

[14]  L Xu,et al.  Computer Modeling of Interactions of an Electric Motor, Circulatory System, and Rotary Blood Pump , 2000, ASAIO journal.

[15]  A. Guyton,et al.  Textbook of Medical Physiology , 1961 .

[16]  Gang Tao,et al.  Modeling, Estimation, and Control of Human Circulatory System With a Left Ventricular Assist Device , 2007, IEEE Transactions on Control Systems Technology.

[17]  N. Alpert,et al.  Redistribution of regional and organ blood volume and effect on cardiac function in relation to upright exercise intensity in healthy human subjects. , 1990, Circulation.

[18]  K. Mckusick,et al.  Redistribution of visceral blood volume in upright exercise in healthy volunteers. , 1988, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  D. Sheriff,et al.  Flow-generating capability of the isolated skeletal muscle pump. , 1998, The American journal of physiology.

[20]  M. H. Laughlin,et al.  Skeletal muscle blood flow capacity: role of muscle pump in exercise hyperemia. , 1987, The American journal of physiology.

[21]  Internal capacitance and resistance allow prediction of right ventricle outflow. , 1982, The American journal of physiology.

[22]  Alexandrina Untaroiu,et al.  Numerical and experimental analysis of an axial flow left ventricular assist device: the influence of the diffuser on overall pump performance. , 2005, Artificial organs.

[23]  J. R. Boston,et al.  Modeling and identification of an axial flow blood pump , 1997, Proceedings of the 1997 American Control Conference (Cat. No.97CH36041).

[24]  J.R. Boston,et al.  Physiological control of left ventricular assist devices based on gradient of flow , 2005, Proceedings of the 2005, American Control Conference, 2005..

[25]  Michael Goldowsky Magnevad--the world's smallest magnetic-bearing turbo pump. , 2004, Artificial organs.

[26]  Atsushi Takeda,et al.  Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes. , 2005, Cardiovascular research.

[27]  佐川 喜一,et al.  Cardiac contraction and the pressure-volume relationship , 1988 .

[28]  Georg Wieselthaler,et al.  Interaction of the cardiovascular system with an implanted rotary assist device: simulation study with a refined computer model. , 2002, Artificial organs.

[29]  J. Longhurst,et al.  Peripheral circulatory control mechanisms in congestive heart failure. , 1973, The American journal of cardiology.

[30]  L. Rowell,et al.  Is rapid rise in vascular conductance at onset of dynamic exercise due to muscle pump? , 1993, The American journal of physiology.

[31]  J. S. Cole,et al.  Dynamic Determinants of Left Ventricular Diastolic Pressure‐Volume Relations in Man , 1975, Circulation.

[32]  M. Ursino,et al.  Cardiovascular response to dynamic aerobic exercise: A methematical model , 2002, Medical and Biological Engineering and Computing.

[33]  B. Saltin,et al.  Muscle blood f low at onset of dynamic exercise in humans. , 1998, American journal of physiology. Heart and circulatory physiology.

[34]  R. D. Manning,et al.  Integrated mechanisms of cardiovascular response and control during exercise in the normal human. , 1976, Progress in cardiovascular diseases.

[35]  K. Brown,et al.  Human right ventricular end-systolic pressure-volume relation defined by maximal elastance. , 1988, Circulation.

[36]  A Cappello,et al.  CADCS simulation of the closed-loop cardiovascular system. , 1988, International journal of bio-medical computing.