The promise of psychiatric enviromics.

BACKGROUND The human genome dwells within environment, determines environment and its expression is shaped by environment. AIMS To introduce 'psychiatric enviromics' as a complement to human genomics and proteomics as applied to mental health. METHOD Selective literature review and synthesis. RESULTS AND CONCLUSIONS Psychiatric enviromics can be planned to sustain the search for specific environments or environmental processes and conditions that promote mental health and reduce the occurrence of psychiatric disturbances. Subsets of the psychiatric envirome will be discovered to have functional importance precisely because specific environmental conditions or processes will reduce, amplify or otherwise modulate the expression of specific genes or multiple gene interactions at identifiable periods of life-span development. Other salubrious environmental conditions and processes will have functional importance but lack specificity of action with respect to gene expression. An international collaboration in the form of a review of evidence is proposed as a starting point for 'psychiatric enviromics'.

[1]  F. Collins,et al.  New goals for the U.S. Human Genome Project: 1998-2003. , 1998, Science.

[2]  J. Anthony,et al.  Perceived risk of cocaine use and experience with cocaine: do they cluster within US neighborhoods and cities? , 2000, Drug and alcohol dependence.

[3]  Frank Bellivier,et al.  Psychiatric genetics: search for phenotypes , 1998, Trends in Neurosciences.

[4]  Sean B. Carroll,et al.  "Development, Plasticity and Evolution of Butterfly Eyespot Patterns" (1996), by Paul M. Brakefield et al. , 2013 .

[5]  K. Kendler,et al.  Cannabis use, abuse, and dependence in a population-based sample of female twins. , 1998, The American journal of psychiatry.

[6]  J. Breitner Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: A current appraisal , 1996, Neurobiology of Aging.

[7]  V. French,et al.  Eyespot development on butterfly wings: the epidermal response to damage. , 1995, Developmental biology.

[8]  W. Blackstock,et al.  Proteome research: Complementarity and limitations with respect to the RNA and DNA worlds , 1997, Electrophoresis.

[9]  W. Eaton,et al.  Epidemiology and social aspects of the human envirome , 1998 .

[10]  N. Craddock,et al.  Modern molecular genetic approaches to complex traits: implications for psychiatric disorders. , 1996, Molecular psychiatry.

[11]  Anthony F Jorm,et al.  A case‐control study of Alzheimer's disease in Australia , 1990, Neurology.

[12]  J. Anthony,et al.  Looking to the future in psychiatric epidemiology. , 1995, Epidemiologic reviews.

[13]  S. Raudenbush,et al.  Neighborhoods and violent crime: a multilevel study of collective efficacy. , 1997, Science.