Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action.
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[1] C. Sautès-Fridman,et al. The Structure of a Human Type III Fcγ Receptor in Complex with Fc* , 2001, The Journal of Biological Chemistry.
[2] S. Fujimoto,et al. Glycosylation and Placental Transport of Immunoglobulin G , 1996 .
[3] S. Akilesh,et al. FcRn: the neonatal Fc receptor comes of age , 2007, Nature Reviews Immunology.
[4] James E. Bailey,et al. Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity , 1999, Nature Biotechnology.
[5] Li Yang,et al. Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequential enzymatic digestion. , 2007, Analytical biochemistry.
[6] R J Harris,et al. Heterogeneity of recombinant antibodies: linking structure to function. , 2005, Developments in biologicals.
[7] T. Daniels,et al. Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells , 2009, Cancer Immunology, Immunotherapy.
[8] R. Dwek,et al. Site-specific glycosylation of recombinant rat and human soluble CD4 variants expressed in Chinese hamster ovary cells. , 1993, The Journal of biological chemistry.
[9] Robert A. Beckman,et al. Antibody-Based Therapy for Solid Tumors , 2008, Cancer journal.
[10] F. Perez,et al. Meeting report & News from academia , 2008 .
[11] P. Parren,et al. Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange , 2007, Science.
[12] Quynh-Thu Le,et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. , 2008, The New England journal of medicine.
[13] M. Basta. Ambivalent effect of immunoglobulins on the complement system: activation versus inhibition. , 2008, Molecular immunology.
[14] Leonard G Presta,et al. Molecular engineering and design of therapeutic antibodies. , 2008, Current opinion in immunology.
[15] J. Deisenhofer. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. , 1981, Biochemistry.
[16] M. Wadhwa,et al. “Cytokine Storm” in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics , 2007, The Journal of Immunology.
[17] Johannes Kneer,et al. Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys. , 2007, Glycobiology.
[18] R. Ghirlando,et al. Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry. , 1999, Immunology letters.
[19] K. Shitara,et al. The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity* , 2003, The Journal of Biological Chemistry.
[20] Jack Hoopes,et al. Humanization of Yeast to Produce Complex Terminally Sialylated Glycoproteins , 2006, Science.
[21] E. Friedländer,et al. ErbB-directed immunotherapy: antibodies in current practice and promising new agents. , 2008, Immunology letters.
[22] D. Burton,et al. Human antibody effector function. , 1992, Advances in immunology.
[23] S. Iida,et al. The N-linked oligosaccharide at FcγRIIIa Asn-45: an inhibitory element for high FcγRIIIa binding affinity to IgG glycoforms lacking core fucosylation , 2008, Glycobiology.
[24] J. Davies,et al. Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII. , 2001, Biotechnology and bioengineering.
[25] Samuel Moser,et al. Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co‐expression of heterologous β1, 4‐N‐acetylglucosaminyltransferase III and Golgi α‐mannosidase II , 2006, Biotechnology and bioengineering.
[26] Roy Jefferis,et al. Glycosylation as a strategy to improve antibody-based therapeutics , 2009, Nature Reviews Drug Discovery.
[27] Thomas M. Dillon,et al. Human IgG2 Antibody Disulfide Rearrangement in Vivo* , 2008, Journal of Biological Chemistry.
[28] C. Szymanski,et al. Campylobacter sugars sticking out. , 2008, Trends in microbiology.
[29] T. Knöchel,et al. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. , 2008, Cancer cell.
[30] Stacey Ma,et al. Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content. , 2008, Biologicals : journal of the International Association of Biological Standardization.
[31] G. Weiner,et al. Complement and cellular cytotoxicity in antibody therapy of cancer , 2008, Expert opinion on biological therapy.
[32] D. Adu,et al. Anti‐neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass , 2004, Clinical and experimental immunology.
[33] Robert Huber,et al. The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex , 2000, Nature.
[34] V. Ghetie,et al. Interactions of immunoglobulins outside the antigen-combining site. , 2004, Advances in immunology.
[35] R. Huber,et al. Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. , 2003, Journal of molecular biology.
[36] David Passmore,et al. Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor , 2006, Nature Biotechnology.
[37] Janice M. Reichert,et al. Development trends for monoclonal antibody cancer therapeutics , 2007, Nature Reviews Drug Discovery.
[38] L. Presta,et al. Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity* , 2002, The Journal of Biological Chemistry.
[39] Shigeru Iida,et al. Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity , 2004, Biotechnology and bioengineering.
[40] R. Kircheis,et al. Compensation of endogenous IgG mediated inhibition of antibody-dependent cellular cytotoxicity by glyco-engineering of therapeutic antibodies. , 2007, Molecular immunology.
[41] M. Peipp,et al. Effector mechanisms of therapeutic antibodies against ErbB receptors. , 2008, Current opinion in immunology.
[42] T. Schneider-Merck,et al. Effector Mechanisms of Recombinant IgA Antibodies against Epidermal Growth Factor Receptor1 , 2007, The Journal of Immunology.
[43] Gary Walsh,et al. Post-translational modifications in the context of therapeutic proteins , 2006, Nature Biotechnology.
[44] Masakazu Toi,et al. A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients , 2007, Clinical Cancer Research.
[45] Roy Jefferis,et al. Antibody therapeutics: , 2007, Expert opinion on biological therapy.
[46] Patricia W. Finn,et al. Receptor-mediated Immunoglobulin G Transport Across Mucosal Barriers in Adult Life , 2002, The Journal of experimental medicine.
[47] P. Carter. Potent antibody therapeutics by design , 2006, Nature Reviews Immunology.
[48] Shigeru Iida,et al. IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides. , 2005, Journal of immunological methods.
[49] A. Bitonti,et al. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[50] L. Simmons,et al. Expression of full-length immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies. , 2002, Journal of immunological methods.
[51] M. Aebi,et al. Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[52] U. Galili,et al. The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance , 2008 .
[53] G. Thibault,et al. Recombinant therapeutic monoclonal antibodies: mechanisms of action in relation to structural and functional duality. , 2007, Critical reviews in oncology/hematology.
[54] J. Ravetch,et al. Fcγ receptors as regulators of immune responses , 2008, Nature Reviews Immunology.
[55] Yoshiki Yamaguchi,et al. Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy. , 2006, Biochimica et biophysica acta.