Sustainable Production of Bio-based Succinic Acid
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The undeniable request for new synthetic routes for bulk chemicals production, which today,
are mostly oil-derived, has arrived together with the urgent need for finding renewable
feedstocks. Industrial biotechnology is often regarded as a potentially environmentally
friendly alternative technology to replace traditional chemical synthesis of several
commodity chemicals from petrochemical based oil refineries, contributing to a more
sustainable chemical industry.
During the last decades of the 20th century, biotechnology and biochemical engineering
have brought to light sugars as alternative raw-materials to produce a wide range of
biobased chemicals aiming for a place of their own in the world chemical market. It is
therefore natural that the United States Department of Energy (US DOE) has identified
several biobased chemicals as market opportunities for reducing fossil fuel dependency in
the chemical industry. These 15 compounds have in common their versatility, as they are
often building blocks for other added value chemicals.
Succinic acid, a dicarboxylic acid, has been used as a precursor for many industrially
important chemicals as shown in Figure 1. Over the last decade, much progress has been
made on the development of a bio-based process for succinic acid production that can
ultimately become competitive with the conventional chemical process. And therefore it was
identified as one of the top candidates as an alternative to oil-derived bulk chemicals.
The scope of this work is to show how succinic acid can be produced in a cost-effective way
from glucose by fed-batch fermentation using recombinant Corynebacterium glutamicum
ΔldhA-pCRA717 (Okino, et al. 2008). This project presents and discusses the impact of a
wheat flour by-products based route to produce succinic acid. An upstream/downstream
process has been designed and optimized for a 10% world market share (18000 ton/year)
and the land footprint was determined.
REFERENCES
Okino, S., Noburyu, R., Suda, M., Jojima, T., Masayuki, I., & Yukawa, H. (2008). An efficient
succinic acid production process in a metabolically engineered Corynebacterium
glutamicum strain . Applied Microbiology and Biotechnology (81), 459-464.
United States Department of Energy. (2004). Top Value Added Chemicals from Biomass.
(T. W. Petersen, Ed.) United States of America.
[1] Masayuki Inui,et al. An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain , 2008, Applied Microbiology and Biotechnology.
[2] Andrea Bernhard,et al. United States of America (U.S.) , 2012 .