Association Between Mannose Binding Lectin Level and Progression of Chronic Hepatitis B

confirm these findings In this study, we investigated the association between MLB level and chronic hepatitis B disease. Abstract Background : Mannose binding lectin (MBL) is believed to be an important component of the innate immune response. MBL may be an important non-invasive predictor for progression of hepatitis B virus infection. In this study, we examined whether there is a relationship between MBL levels and of hepatitis B virus infection. Methods: In this cross-sectional study, fifty patients with chronic hepatitis B and 21healthy control subjects were included. They were classified into three groups: Active hepatitis B, inactive hepatitis B and healthy control groups. The association between MBL level with the stage of fibrosis and histological activity index (HAI) was found in patients with active chronic hepatitis B. Results : The mean ± SD of MBL level was as 2875.3 ± 2040.03 ng/ml in active HBV patients, 2463.9 ± 1915.4 ng / ml in inactive HBV patients, and 1865.04 265.6 ng/ml in healthy controls (P: 0.344). was not significantly correlated with HAI and the stage of fibrosis (r: -0.30, P: 0.876 and r: 0.077, P: 0.687, respectively).

[1]  R. Thimme,et al.  Natural history of chronic hepatitis B virus infection , 2015, Medical Microbiology and Immunology.

[2]  M. Albannan,et al.  Noninvasive Diagnosis of Liver Fibrosis and Cirrhosis in Chronic Hepatitis C Patients , 2013, Journal of clinical laboratory analysis.

[3]  Syed Azhar Ahmed,et al.  FibroScore for the non-invasive assessment of liver fibrosis in chronic viral hepatitis. , 2012, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[4]  Jong Eun Lee,et al.  Lack of Association between Hepatitis B Virus Infection and Polymorphism of Mannose-Binding Lectin Gene in Korean Population , 2005, Journal of Korean medical science.

[5]  M. Christiansen,et al.  Human Plasma‐Derived Mannose‐Binding Lectin: A Phase I Safety and Pharmacokinetic Study , 2004, Scandinavian journal of immunology.

[6]  D. Kershenobich Stalnikowitz,et al.  Liver fibrosis and inflammation. A review. , 2003, Annals of hepatology.

[7]  R. Jordan,et al.  Molecular viral oncology of hepatocellular carcinoma , 2003, Oncogene.

[8]  P. Kremsner,et al.  Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients. , 2003, Mutation research.

[9]  J. Iwamoto,et al.  Mannose-binding lectin and the prognosis of fulminant hepatic failure caused by HBV infection. , 2002, Liver.

[10]  Y. Lau,et al.  Mannose binding lectin gene mutations are associated with progression of liver disease in chronic hepatitis B infection , 1999, Hepatology.

[11]  S. Thiel,et al.  Mannan-binding protein and complement dependent opsonization in alcoholic cirrhosis. , 2008, Liver.

[12]  H C Thomas,et al.  Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. , 1995, The New England journal of medicine.

[13]  M. Turner,et al.  Mannose binding protein gene mutations associated with unusual and severe infections in adults , 1995, The Lancet.

[14]  Robert B Sim,et al.  Localization of the receptor-binding site in the collectin family of proteins. , 1993, The Biochemical journal.