The physicochemical stability and in vitro bioaccessibility of beta-carotene in oil-in-water sodium caseinate emulsions

Abstract Beta-carotene (BC), the most important dietary source of provitamin A, is necessary for optimum human health. BC is insoluble or only slightly soluble in most liquids but its bioavailability improves when ingested with fat. Therefore lipid emulsions are ideal matrices for BC delivery. BC (0.1%) in corn oil, the dispersed phase (5 or 10%), was homogenized with 2% sodium caseinate solution in a microfluidizer. Homogenization at different pressures produced droplet diameters (Dz = 368–124 nm) that were linear and inversely related to homogenization pressures in the pressure range 10–100 MPa. Nanoemulsions (r

[1]  D. Bertrand,et al.  Oxidative stability of oil-in-water emulsions stabilised with protein or surfactant emulsifiers in various oxidation conditions , 2012 .

[2]  I. Norton,et al.  Comparing droplet breakup for a high-pressure valve homogeniser and a Microfluidizer for the potential production of food-grade nanoemulsions , 2013 .

[3]  Yanxiang Gao,et al.  Investigation into the bioaccessibility and microstructure changes of β-carotene emulsions during in vitro digestion , 2012 .

[4]  D. Mcclements,et al.  Mechanisms of lipid oxidation in food dispersions , 2011 .

[5]  D. Mcclements,et al.  Influence of emulsifier type on in vitro digestibility of lipid droplets by pancreatic lipase , 2007 .

[6]  D. Mcclements,et al.  Use of caseinophosphopeptides as natural antioxidants in oil-in-water emulsions. , 2003, Journal of agricultural and food chemistry.

[7]  H. Tan,et al.  Na-caseinate/oil/water systems: emulsion morphology diagrams. , 2012, Journal of colloid and interface science.

[8]  D. Dalgleish,et al.  The characterization of small emulsion droplets made from milk proteins and triglyceride oil , 1997 .

[9]  Hailong Yu,et al.  Development of a food-grade organogel with high bioaccessibility and loading of curcuminoids , 2012 .

[10]  M. Corredig,et al.  Comparison on the effect of high-methoxyl pectin or soybean-soluble polysaccharide on the stability of sodium caseinate-stabilized oil/water emulsions. , 2007, Journal of agricultural and food chemistry.

[11]  N. Shibasaki-Kitakawa,et al.  A kinetic model for co-oxidation of β-carotene with oleic acid , 2001 .

[12]  T. Grune,et al.  The contribution of β-carotene to vitamin A supply of humans. , 2012, Molecular nutrition & food research.

[13]  Xiaoqin Yang,et al.  Stability and bioaccessibility of β-carotene in nanoemulsions stabilized by modified starches. , 2013, Journal of agricultural and food chemistry.

[14]  D. Lairon,et al.  Hydrolysis of emulsions with different triglycerides and droplet sizes by gastric lipase in vitro. Effect on pancreatic lipase activity , 1994 .

[15]  Qingrong Huang,et al.  Bioavailability and delivery of nutraceuticals using nanotechnology. , 2010, Journal of food science.

[16]  Shih-Chuan Liu,et al.  Determination of cis- and trans- α- and β-carotenoids in Taiwanese sweet potatoes (Ipomoea batatas (L.) Lam.) harvested at various times , 2009 .

[17]  M. Nakajima,et al.  Factors affecting droplet size of sodium caseinate-stabilized O/W emulsions containing β-carotene , 2007 .

[18]  P Borel,et al.  Carotenoids in biological emulsions: solubility, surface-to-core distribution, and release from lipid droplets. , 1996, Journal of lipid research.

[19]  D. Mcclements,et al.  Nanoemulsion delivery systems: influence of carrier oil on β-carotene bioaccessibility. , 2012, Food chemistry.

[20]  D. Mcclements,et al.  New mathematical model for interpreting pH-stat digestion profiles: impact of lipid droplet characteristics on in vitro digestibility. , 2015 .

[21]  Like Mao,et al.  Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions , 2008 .

[22]  D. Mcclements,et al.  Influence of particle size on lipid digestion and β-carotene bioaccessibility in emulsions and nanoemulsions. , 2013, Food chemistry.

[23]  Y. Roos,et al.  Stability of β-carotene in protein-stabilized oil-in-water delivery systems. , 2011, Journal of agricultural and food chemistry.

[24]  Duoxia Xu,et al.  Effects of Homogenization Models and Emulsifiers on the Physicochemical Properties of β-Carotene Nanoemulsions , 2010 .

[25]  D. Mcclements,et al.  Protein-stabilized nanoemulsions and emulsions: comparison of physicochemical stability, lipid oxidation, and lipase digestibility. , 2011, Journal of agricultural and food chemistry.

[26]  D. Mcclements,et al.  Factors affecting lipase digestibility of emulsified lipids using an in vitro digestion model: Proposal for a standardised pH-stat method , 2011 .

[27]  Yen Wei,et al.  Effects of acidity on the size of polyaniline-poly(sodium 4-styrenesulfonate) composite particles and the stability of corresponding colloids in water. , 2012, Journal of colloid and interface science.

[28]  L. Lethuaut,et al.  Effect of droplet size on lipid oxidation rates of oil-in-water emulsions stabilized by protein , 2002 .

[29]  E. Dickinson Properties of emulsions stabilized with milk proteins: overview of some recent developments , 1997 .

[30]  M. Failla,et al.  Accumulation and retention of micellar beta-carotene and lutein by Caco-2 human intestinal cells. , 1999, The Journal of nutritional biochemistry.

[31]  R. Verger,et al.  Lipase kinetics at the triacylglycerol-water interface using surface tension measurements. , 1987, Chemistry and physics of lipids.

[32]  Takuji Tanaka,et al.  Cancer Chemoprevention by Caroteno , 2012, Molecules.

[33]  M. Failla,et al.  Impact of fatty acyl composition and quantity of triglycerides on bioaccessibility of dietary carotenoids. , 2007, Journal of agricultural and food chemistry.

[34]  D. Mcclements,et al.  Lipid oxidation in corn oil-in-water emulsions stabilized by casein, whey protein isolate, and soy protein isolate. , 2003, Journal of agricultural and food chemistry.

[35]  C. Mathers,et al.  Maternal and child undernutrition: global and regional exposures and health consequences , 2008, The Lancet.

[36]  D. Mcclements,et al.  Potential biological fate of ingested nanoemulsions: influence of particle characteristics. , 2012, Food & function.

[37]  M. Nakajima,et al.  Preliminary study into the factors modulating β-carotene micelle formation in dispersions using an in vitro digestion model , 2012 .

[38]  J. Aguilera,et al.  Influence of particle size on the in vitro digestibility of protein-coated lipid nanoparticles. , 2012, Journal of colloid and interface science.