The Pineal Gland and Its Hormones

[1]  J. Redman,et al.  Melatonin administration: effects on rodent circadian rhythms. , 2008, Ciba Foundation symposium.

[2]  S. Folkard,et al.  Some effects of melatonin and the control of its secretion in humans. , 2008, Ciba Foundation symposium.

[3]  D. Harman Free‐Radical Theory of Aging , 1992, Mutation research.

[4]  P. Morgan,et al.  Evidence for Multiple Forms of Melatonin Receptor‐G‐Protein Complexes by Solubilization and Gel Electrophoresis , 1994, Journal of neuroendocrinology.

[5]  J. Arendt,et al.  Acute phase-shifting effects of melatonin associated with suppression of core body temperature in humans , 1994, Neuroscience Letters.

[6]  G. Lincoln Effects of placing micro-implants of melatonin in the pars tuberalis, pars distalis and the lateral septum of the forebrain on the secretion of FSH and prolactin, and testicular size in rams. , 1994, The Journal of endocrinology.

[7]  J. Taillard,et al.  Melatonin is able to influence its secretion in humans: description of a phase-response curve. , 1994, Neuroendocrinology.

[8]  R. Reiter,et al.  Melatonin prevents the suppression of cardiac Ca(2+)-stimulated ATPase activity induced by alloxan. , 1994, The American journal of physiology.

[9]  R. Reiter,et al.  Melatonin: Multifaceted messenger to the masses , 1994 .

[10]  R. Reiter,et al.  Melatonin As a Free Radical Scavenger: Implications for Aging and Age‐Related Diseases a , 1994, Annals of the New York Academy of Sciences.

[11]  S. Simon,et al.  Cell biological mechanisms of multidrug resistance in tumors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A. Meister Glutathione, ascorbate, and cellular protection. , 1994, Cancer research.

[13]  D. Sugden N-acyl-3-amino-5-methoxychromans: a new series of non-indolic melatonin analogues. , 1994, European journal of pharmacology.

[14]  R. Wurtman,et al.  Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[15]  R. Reiter,et al.  Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole. , 1994, Carcinogenesis.

[16]  D. McElhinney,et al.  Effect of melatonin on human skin color. , 1994, The Journal of investigative dermatology.

[17]  A. Duranti,et al.  2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity. , 1993, Journal of medicinal chemistry.

[18]  M. Mirmiran,et al.  Effects of a novel melatonin analog on circadian rhythms of body temperature and activity in young, middle-aged, and old rats , 1993, Neurobiology of Aging.

[19]  S. Hill,et al.  Melatonin modulation of estrogen-receptor expression in mcf-7 human breast-cancer cells. , 1993, International journal of oncology.

[20]  M. P. L. Mora,et al.  Circadian rhythmicity in the GABAergic system in the suprachiasmatic nuclei of the rat , 1993, Neuroscience Letters.

[21]  R. Reiter,et al.  The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivo. , 1993, Cancer letters.

[22]  A. Slominski,et al.  Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. , 1993, Experimental cell research.

[23]  S. Hahn,et al.  Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity. , 1993, Cancer research.

[24]  H. Laborit,et al.  Antioxidant activity of melatonin in mice. , 1993, Research communications in chemical pathology and pharmacology.

[25]  V. Gayrard,et al.  Short-day effects of melatonin on luteinizing hormone secretion in the ewe: evidence for central sites of action in the mediobasal hypothalamus. , 1993, Biology of reproduction.

[26]  A. Cagnacci,et al.  The effect of light on core body temperature is mediated by melatonin in women. , 1993, The Journal of clinical endocrinology and metabolism.

[27]  L. Kothari,et al.  A possible modulatory influence of melatonin on representative phase I and II drug metabolizing enzymes in 9,10‐dimethyl‐1,2‐benzanthracene induced rat mammary tumorigenesis , 1992, Anti-cancer drugs.

[28]  E. Maywood,et al.  Non-photic phase shifting of the circadian activity rhythm of Syrian hamsters: the relative potency of arousal and melatonin , 1992, Brain Research.

[29]  L. Loeb,et al.  DNA damage and repair in brain: relationship to aging. , 1992, Mutation research.

[30]  Takamatsu Yasuo,et al.  Inhibition of human hepatic glutathione S-transferase isozymes by ethacrynic acid and its metabolites. , 1992 .

[31]  S. Yen,et al.  Melatonin: a major regulator of the circadian rhythm of core temperature in humans. , 1992, The Journal of clinical endocrinology and metabolism.

[32]  D. Blask,et al.  Melatonin augments the sensitivity of MCF-7 human breast cancer cells to tamoxifen in vitro. , 1992, The Journal of clinical endocrinology and metabolism.

[33]  L. M. Williams,et al.  Melatonin Binding Sites in the Ovine Brain and Pituitary: Characterization During the Oestrous Cycle , 1992, Journal of neuroendocrinology.

[34]  D. Lesieur,et al.  Novel naphthalenic ligands with high affinity for the melatonin receptor. , 1992, Journal of medicinal chemistry.

[35]  B. Cozzi,et al.  Melatonin signal transduction and mechanism of action in the central nervous system: using the rabbit cortex as a model. , 1992, Endocrinology.

[36]  P. Lavie,et al.  The importance of timing in melatonin administration in a blind man , 1992, Journal of pineal research.

[37]  J. Arendt,et al.  Melatonin suppression in human subjects by bright and dim light in Antarctica: time and season-dependent effects , 1992, Neuroscience Letters.

[38]  N. Davidson,et al.  Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance. , 1992, Cancer research.

[39]  R. Reiter,et al.  The ageing pineal gland and its physiological consequences , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[40]  J. Vanecek,et al.  Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. , 1992, Endocrinology.

[41]  K. Maeda,et al.  Reproductive effects of placing micro-implants of melatonin in the mediobasal hypothalamus and preoptic area in rams. , 1992, The Journal of endocrinology.

[42]  E. Maywood,et al.  The Effect of Signal Frequency on the Gonadal Response of Male Syrian Hamsters to Programmed Melatonin Infusions , 1992, Journal of neuroendocrinology.

[43]  T. Wehr,et al.  The durations of human melatonin secretion and sleep respond to changes in daylength (photoperiod). , 1991, The Journal of clinical endocrinology and metabolism.

[44]  Y. Ben-Ari,et al.  GABA: an excitatory transmitter in early postnatal life , 1991, Trends in Neurosciences.

[45]  Anna Wirz-Justice,et al.  A human phase-response curve to light , 1991, Neuroscience Letters.

[46]  M. Gillette,et al.  Melatonin directly resets the rat suprachiasmatic circadian clock in vitro , 1991, Brain Research.

[47]  J. Cockrem,et al.  Melatonin levels in hospitalized elderly patients: a comparison with community based volunteers. , 1991, Age and ageing.

[48]  R. Reiter,et al.  Melatonin binding sites in the central nervous system , 1991, Brain Research Reviews.

[49]  D. Streiner,et al.  The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: A preliminary study , 1991, Biological Psychiatry.

[50]  D. Kennaway,et al.  Free-running rhythms of melatonin, cortisol, electrolytes, and sleep in humans in Antarctica. , 1991, The American journal of physiology.

[51]  E. Maywood,et al.  Occlusion of the Melatonin‐Free Interval Blocks the Short Day Gonadal Response of the Male Syrian Hamster to Programmed Melatonin Infusions of Necessary Duration and Amplitude , 1991, Journal of neuroendocrinology.

[52]  J. Parkes,et al.  Delayed sleep phase syndrome response to melatonin , 1991, The Lancet.

[53]  Melvin I. Simon,et al.  Diversity of G proteins in signal transduction , 1991, Science.

[54]  N. Lassen,et al.  Human Regional Cerebral Blood Flow during Rapid-Eye-Movement Sleep , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[55]  R. Reiter,et al.  Pineal melatonin: cell biology of its synthesis and of its physiological interactions. , 1991, Endocrine reviews.

[56]  L. Wetterberg,et al.  Correction of non–24‐hour sleep/wake cycle by melatonin in a blind retarded boy , 1991, Annals of neurology.

[57]  G. Batist,et al.  Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines. , 1991, Biochemical pharmacology.

[58]  S. Cos,et al.  Effects of melatonin on the cell cycle kinetics and “estrogen‐rescue” of MCF‐7 human breast cancer cells in culture , 1991, Journal of pineal research.

[59]  W. Robinson,et al.  Surgical treatment of brain metastases in malignant melanoma , 1990, Cancer.

[60]  D. Waxman,et al.  Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review. , 1990, Cancer research.

[61]  R. Pourcho,et al.  Colocalization of substance P and GABA in retinal ganglion cells: A computer-assisted visualization , 1990, Visual Neuroscience.

[62]  A. Wirz-Justice,et al.  The relationship of affective state to dietary preference: winter depression and light therapy as a model. , 1990, Journal of affective disorders.

[63]  Till Roenneberg,et al.  Annual Rhythm of Human Reproduction: I. Biology, Sociology, or Both? , 1990, Journal of biological rhythms.

[64]  E. Maywood,et al.  Gonadal responses of the male Syrian hamster to programmed infusions of melatonin are sensitive to signal duration and frequency but not to signal phase nor to lesions of the suprachiasmatic nuclei. , 1990, Biology of reproduction.

[65]  M. Dubocovich,et al.  Activation of Melatonin Receptor Sites Retarded the Depletion of Norepinephrine Following Inhibition of Synthesis in the C3H/HeN Mouse Hypothalamus , 1990, Journal of neurochemistry.

[66]  B. Ames,et al.  Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[67]  A. Girotti,et al.  PHOTODYNAMIC LIPID PEROXIDATION IN BIOLOGICAL SYSTEMS * , 1990, Photochemistry and photobiology.

[68]  F. Davis,et al.  Transplanted suprachiasmatic nucleus determines circadian period. , 1990, Science.

[69]  R. Floyd,et al.  Role of oxygen free radicals in carcinogenesis and brain ischemia , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[70]  M. Menaker,et al.  GABA regulation of circadian responses to light. I. Involvement of GABAA-benzodiazepine and GABAB receptors , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[71]  R. Kronauer,et al.  Bright light induction of strong (type 0) resetting of the human circadian pacemaker. , 1989, Science.

[72]  R. Wever,et al.  Light Effects on Human Circadian Rhythms: A Review of Recent Andechs Experiments , 1989, Journal of biological rhythms.

[73]  E. Mignot,et al.  Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[74]  R. Newcombe,et al.  Effect of melatonin on jet lag after long haul flights. , 1989, BMJ.

[75]  S. Shibata,et al.  Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro , 1989, Neuroscience Letters.

[76]  R. Mason,et al.  The electrophysiological effects of melatonin and a putative melatonin antagonist (N-acetyltryptamine) on rat suprachiasmatic neurones in vitro , 1988, Neuroscience Letters.

[77]  S. Hill,et al.  Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. , 1988, Cancer research.

[78]  S. Rivkees,et al.  Putative melatonin receptors in a human biological clock. , 1988, Science.

[79]  P. Lestage,et al.  Plasma, Cerebrospinal Fluid, and Brain Distribution of 14C‐Melatonin in Rat: A Biochemical and Autoradiographic Study , 1988, Journal of pineal research.

[80]  M. Dubocovich,et al.  Luzindole (N-0774): a novel melatonin receptor antagonist. , 1988, The Journal of pharmacology and experimental therapeutics.

[81]  S. Armstrong,et al.  Melatonin administration entrains female rat activity rhythms in constant darkness but not in constant light. , 1988, The American journal of physiology.

[82]  L. Krebs,et al.  Malignant melanoma--profile of an epidemic. , 1988, The Western journal of medicine.

[83]  K. Tew,et al.  Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines. , 1988, Cancer research.

[84]  G. Lynch,et al.  Daily melatonin injections affect the expression of circadian rhythmicity in Djungarian hamsters kept under a long-day photoperiod. , 1988, Neuroendocrinology.

[85]  J. Arendt,et al.  SYNCHRONISATION OF A DISTURBED SLEEP-WAKE CYCLE IN A BLIND MAN BY MELATONIN TREATMENT , 1988, The Lancet.

[86]  M. Hastings,et al.  Intra-hypothalamic melatonin blocks photoperiodic responsiveness in the male syrian hamster , 1988, Neuroscience.

[87]  L. Yatham,et al.  Down's syndrome and its association with Alzheimer's disease , 1988, Acta psychiatrica Scandinavica.

[88]  S. Armstrong,et al.  Melatonin phase shifts a mammalian circadian clock , 1987 .

[89]  D. Skene,et al.  Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man , 1987, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[90]  M. Hastings,et al.  Effect of asymmetrical reductions of photoperiod on pineal melatonin, locomotor activity and gonadal condition of male Syrian hamsters. , 1987, The Journal of endocrinology.

[91]  M. Gerkema,et al.  University of Groningen Differential Effects of Pinealectomy on Circadian Rhythms of Feeding and Perch Hopping in the European Starling Gwinner, , 2010 .

[92]  S. Kapen,et al.  The cardioacceleratory response to arecoline infusion during sleep in narcoleptic subjects and controls. , 1987, Sleep.

[93]  D. Cardinali,et al.  Melatonin increases in vivo GABA accumulation in rat hypothalamus, cerebellum, cerebral cortex and pineal gland , 1986, Brain Research.

[94]  J. Shaw,et al.  Elevation of intracellular glutathione content associated with mitogenic stimulation of quiescent fibroblasts , 1986, Journal of cellular physiology.

[95]  M. V. Reddy,et al.  Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts. , 1986, Carcinogenesis.

[96]  Eugene Roberts,et al.  What do GABA neurons really do? They make possible variability generation in relation to demand , 1986, Experimental Neurology.

[97]  B. Worgul,et al.  Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice. , 1986, Science.

[98]  J. Arendt,et al.  Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. , 1986, British medical journal.

[99]  D. Cardinali,et al.  Diurnal Variations of Benzodiazepine Binding in Rat Cerebral Cortex: Disruption by Pinealectomy , 1986, Journal of pineal research.

[100]  H. Underwood Circadian Rhythms in Lizards: Phase Response Curve for Melatonin , 1986, Journal of pineal research.

[101]  N. Zisapel,et al.  Characterization of central melatonin receptors using 125I‐melatonin , 1986, FEBS letters.

[102]  J. Arendt,et al.  Effects of various melatonin treatments on plasma prolactin concentrations in the ewe. , 1986, The Journal of endocrinology.

[103]  O. Vakkuri,et al.  Oral administration and distribution of melatonin in human serum, saliva and urine. , 1985, Life sciences.

[104]  I. Zucker,et al.  Persistence of circannual rhythms in ground squirrels with lesions of the suprachiasmatic nuclei , 1985, Brain Research.

[105]  C. Nathan,et al.  Glutathione metabolism as a determinant of therapeutic efficacy: a review. , 1984, Cancer research.

[106]  B. Goldman,et al.  Antigonadal effects of timed melatonin infusion in pinealectomized male Djungarian hamsters (Phodopus sungorus sungorus): duration is the critical parameter. , 1983, Endocrinology.

[107]  P. Nutley Hypnotics and anxiolytics , 1983 .

[108]  B. Goldman,et al.  The pineal gland and mammalian photoperiodism. , 1983, Neuroendocrinology.

[109]  J. Redman,et al.  Free-running activity rhythms in the rat: entrainment by melatonin. , 1983, Science.

[110]  P. Cowen,et al.  Direct radioimmunoassay for melatonin in plasma. , 1983, Clinical chemistry.

[111]  W. Malaisse Alloxan toxicity to the pancreatic B-cell. A new hypothesis. , 1982, Biochemical pharmacology.

[112]  H. Iguchi,et al.  Melatonin serum levels and metabolic clearance rate in patients with liver cirrhosis. , 1982, The Journal of clinical endocrinology and metabolism.

[113]  C. E. McCormack,et al.  Failure of pinealectomy or melatonin to alter circadian activity rhythm of the rat. , 1982, The American journal of physiology.

[114]  Peter Knauth,et al.  Re-entrainment of body temperature in field studies of shiftwork , 1981 .

[115]  H. J. Chen Melatonin: failure of pharmacological doses to induce testicular atrophy in the male golden hamster. , 1981, Life sciences.

[116]  E. Finkelstein,et al.  Spin trapping. Kinetics of the reaction of superoxide and hydroxyl radicals with nitrones , 1980 .

[117]  V. H. Hutchison,et al.  Melatonin and chlorpromazine: thermal selection in the mudpuppy, Necturus maculosus. , 1979, Life sciences.

[118]  D. Cardinali,et al.  Specific binding of melatonin in bovine brain. , 1979, Endocrinology.

[119]  G. Brown,et al.  Melatonin receptors in brain. , 1979, European journal of pharmacology.

[120]  J. Parkes,et al.  DEPRENYL IN NARCOLEPSY , 1979, The Lancet.

[121]  H. Romijn The pineal, a tranquillizing organ? , 1978, Life sciences.

[122]  J. Nordlund,et al.  The effects of oral melatonin on skin color and on the release of pituitary hormones. , 1977, The Journal of clinical endocrinology and metabolism.

[123]  M. Menaker,et al.  Melatonin: effects on the circadian locomotor rhythm of sparrows. , 1976, Science.

[124]  C. Heward,et al.  Structure-activity relationships of melatonin and related indoleamines. , 1975, Life sciences.

[125]  J A Hobson,et al.  Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. , 1975, Science.

[126]  R. Reiter Pineal control of a seasonal reproductive rhythm in male golden hamsters exposed to natural daylight and temperature. , 1973, Endocrinology.

[127]  R. Wurtman,et al.  Binding of melatonin to human and rat plasma proteins. , 1972, Endocrinology.

[128]  W. B. Quay Pineal homeostatic regulation of shifts in the circadian activity rhythm during maturation and aging. , 1972, Transactions of the New York Academy of Sciences.

[129]  S. Kveder,et al.  The metabolism of melatonin (N-acetyl-5-methoxytryptamine) and 5-methoxytryptamine. , 1961, The Journal of biological chemistry.

[130]  A. Lerner,et al.  ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES1 , 1958 .

[131]  R. Reiter,et al.  Pineal function during aging: attenuation of the melatonin rhythm and its neurobiological consequences. , 1994, Acta neurobiologiae experimentalis.

[132]  S. Folkard,et al.  Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. , 1993, Chronobiology international.

[133]  R. Reiter,et al.  Antioxidant capacity of melatonin: A novel action not requiring a receptor , 1993 .

[134]  A. Meister Approaches To The Therapy Of Glutathione Deficiency , 1993 .

[135]  A. Lewy,et al.  Melatonin shifts human circadian rhythms according to a phase-response curve. , 1992, Chronobiology international.

[136]  A. Duranti,et al.  2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist. , 1992, Life sciences.

[137]  M. Moline Biological Rhythms, Mood Disorders, Light Therapy, and the Pineal Gland , 1992 .

[138]  M. Dubocovich,et al.  Melatonin receptors. , 1991, Annual review of pharmacology and toxicology.

[139]  A. Meister Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. , 1991, Pharmacology & therapeutics.

[140]  M. Hastings Neuroendocrine rhythms. , 1991, Pharmacology & therapeutics.

[141]  G. E. Pickard,et al.  Circadian locomotor rhythms in the desert iguana. II. Effects of electrolytic lesions to the hypothalamus. , 1990, Journal of comparative physiology. A, Sensory, neural, and behavioral physiology.

[142]  E. Stadtman,et al.  Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences. , 1990, Free radical biology & medicine.

[143]  K. Cowan,et al.  Differential increases in glutathione S-transferase activities in a range of multidrug-resistant human tumor cell lines. , 1989, Cancer communications.

[144]  A. Lewy,et al.  Free-Running Melatonin Rhythms in Blind People: Phase Shifts with Melatonin and Triazolam Administration , 1987 .

[145]  F. Waldhauser,et al.  Changes in melatonin secretion with age and pubescence. , 1986, Journal of neural transmission. Supplementum.

[146]  I. Fridovich,et al.  Antioxidant defenses in the lung. , 1986, Annual review of physiology.

[147]  A. Girotti Mechanisms of lipid peroxidation. , 1985, Journal of free radicals in biology & medicine.

[148]  B. Goldman,et al.  Testicular function and pelage color have different critical daylengths in the Djungarian hamster, Phodopus sungorus sungorus. , 1985, Endocrinology.

[149]  R Gomeni,et al.  PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation. , 1984, Computers in biology and medicine.

[150]  M. Menaker The Search for Principles of Physiological Organization in Vertebrate Circadian Systems , 1982 .

[151]  P. Semm,et al.  Sleep Induction by Intranasal Application of Melatonin , 1981 .

[152]  R. Short,et al.  Seasonal breeding: nature's contraceptive. , 1980, Recent progress in hormone research.

[153]  M. Rollag,et al.  Effects of photoperiod on hamster pineal melatonin concentrations , 1980 .

[154]  J. Aschoff,et al.  Exogenous and endogenous components in circadian rhythms. , 1960, Cold Spring Harbor symposia on quantitative biology.

[155]  Ro Intrinsic actions of the benzodiazepine receptor antagonist Ro 15-1788 , 2022 .