A wave traveling over a Hopf instability shapes the cochlear tuning curve.

The tuning curve of the cochlea measures how intense an input is required to elicit a given output level as a function of the frequency. It is a fundamental object of auditory theory, for it summarizes how to identify sounds on the basis of the cochlear output. A simple model is presented showing that only two elements are sufficient for establishing the cochlear tuning curve: a broadly tuned traveling wave, moving unidirectionally from high to low frequencies, and a set of mechanosensors poised at the threshold of an oscillatory (Hopf) instability. These two components generate the various frequency-response regimes needed for a cochlear tuning curve with a high slope.

[1]  M. Ruggero,et al.  Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Magnasco,et al.  Evidence of a Hopf bifurcation in frog hair cells. , 2001, Biophysical journal.

[3]  G. Manley,et al.  Evidence for an active process and a cochlear amplifier in nonmammals. , 2001, Journal of neurophysiology.

[4]  A. Hudspeth,et al.  Essential nonlinearities in hearing. , 2000, Physical review letters.

[5]  M O Magnasco,et al.  A model for amplification of hair-bundle motion by cyclical binding of Ca2+ to mechanoelectrical-transduction channels. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[6]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[7]  I. Russell,et al.  The spatial and temporal representation of a tone on the guinea pig basilar membrane. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Thomas Gold,et al.  Hearing. II. The Physical Basis of the Action of the Cochlea , 1948, Proceedings of the Royal Society of London. Series B - Biological Sciences.

[9]  A J Hudspeth,et al.  Active hair-bundle movements can amplify a hair cell's response to oscillatory mechanical stimuli. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  F. Jülicher,et al.  Auditory sensitivity provided by self-tuned critical oscillations of hair cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Jonathan Ashmore,et al.  The cochlea , 2000, Current Biology.

[12]  F Mammano,et al.  Biophysics of the cochlea. II: Stationary nonlinear phenomenology. , 1996, The Journal of the Acoustical Society of America.

[13]  R S Chadwick Compression, gain, and nonlinear distortion in an active cochlear model with subpartitions. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A J Hudspeth,et al.  Compressive nonlinearity in the hair bundle's active response to mechanical stimulation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Duke,et al.  Physical basis of two-tone interference in hearing , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[16]  M. Ruggero Responses to sound of the basilar membrane of the mammalian cochlea , 1992, Current Opinion in Neurobiology.