Detection of glucose-induced scattering change in turbid medium

Diffuse scattering measurements to determine the changes of glucose concentration in a highly scattering medium are conducted by using an optical heterodyne technique. The heterodyne technique can increase the signal-to-noise ratio (SNR) of the detection amplitude and phase by coherence gating and narrow detection bandwidth. The experimental results showed that a good sensitivity of 0.1% scattering change per mM is observed.

[1]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[2]  E Gratton,et al.  Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared. , 1994, Optics letters.

[3]  R. Steiner,et al.  Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue. , 1996, Applied optics.

[4]  T. B. Blank,et al.  Noninvasive prediction of glucose by near-infrared diffuse reflectance spectroscopy. , 1999, Clinical chemistry.

[5]  L. O. Svaasand,et al.  Boundary conditions for the diffusion equation in radiative transfer. , 1994, Journal of the Optical Society of America. A, Optics, image science, and vision.

[6]  M. Cope,et al.  Optical properties of highly scattering media determined from changes in attenuation, phase, and modulation depth. , 1997, Applied optics.

[7]  M. Cope,et al.  Influence of glucose concentration on light scattering in tissue-simulating phantoms. , 1994, Optics letters.

[8]  Hon-Fai Yau,et al.  Properties of a diffused photon-pair density wave in a multiple-scattering medium. , 2005, Applied optics.

[9]  B. Tromberg,et al.  Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy , 2000 .

[10]  Shoji Takeuchi,et al.  Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring , 2010, Proceedings of the National Academy of Sciences.

[11]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[12]  W. March,et al.  Noninvasive Glucose Monitoring of the Aqueous Humor of the Eye: Part II. Animal Studies and the Scleral Lens , 1982, Diabetes Care.

[13]  R. Esenaliev,et al.  Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects. , 2002, Diabetes care.

[14]  B. Wilson,et al.  Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue. , 1991, Applied optics.

[15]  R. Esenaliev,et al.  Noninvasive monitoring of glucose concentration with optical coherence tomography , 2001 .

[16]  Sergio Fantini,et al.  Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation , 1994 .

[17]  Gerard L. Cot,et al.  Application of a multivariate technique to Raman spectra for quantification of body chemicals , 1995, IEEE Transactions on Biomedical Engineering.

[18]  Marilyn Cox,et al.  An overview of continuous glucose monitoring systems. , 2009, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[19]  Y Zhang,et al.  Effects of solutes on optical properties of biological materials: models, cells, and tissues. , 1995, Analytical biochemistry.

[20]  B Chance,et al.  Dependence of tissue optical properties on solute-induced changes in refractive index and osmolarity. , 1996, Journal of biomedical optics.

[21]  Jody T. Bruulsema,et al.  Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient. , 1997, Optics letters.

[22]  K. Petermann Laser Diode Modulation and Noise , 1988 .