Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice

Cancer cachexia is largely irreversible, at least via nutritional means, and responsible for 20–40% of cancer‐related deaths. Therefore, preventive measures are of primary importance; however, little is known about muscle perturbations prior to onset of cachexia. Cancer cachexia is associated with mitochondrial degeneration; yet, it remains to be determined if mitochondrial degeneration precedes muscle wasting in cancer cachexia. Therefore, our purpose was to determine if mitochondrial degeneration precedes cancer‐induced muscle wasting in tumour‐bearing mice.

[1]  Stephan von Haehling,et al.  Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2015 , 2015, Journal of cachexia, sarcopenia and muscle.

[2]  S. Welle,et al.  The Regulation of Skeletal Muscle Protein Turnover During the Progression of Cancer Cachexia in the Apc Min / + Mouse , 2019 .

[3]  J. Fluckey,et al.  PGC‐1α4 gene expression is suppressed by the IL‐6—MEK—ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury , 2017, Acta physiologica.

[4]  B. Kong,et al.  Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size. , 2017, Physiological genomics.

[5]  M. Guillot,et al.  Muscles Susceptibility to Ischemia-Reperfusion Injuries Depends on Fiber Type Specific Antioxidant Level , 2017, Front. Physiol..

[6]  David E. Lee,et al.  Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. , 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[7]  Jose M Garcia,et al.  Update on Management of Cancer-Related Cachexia , 2017, Current Oncology Reports.

[8]  A. Russell,et al.  Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients , 2017, Human molecular genetics.

[9]  M. Muscaritoli,et al.  Perspectives of health care professionals on cancer cachexia: results from three global surveys , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  David E. Lee,et al.  Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet‐induced obese mice , 2016, Acta physiologica.

[11]  S. Powers,et al.  Redox control of skeletal muscle atrophy. , 2016, Free radical biology & medicine.

[12]  David E. Lee,et al.  Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration , 2016, Mechanisms of Ageing and Development.

[13]  J. Carson,et al.  The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting. , 2016, Seminars in cell & developmental biology.

[14]  J. Wada,et al.  Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes. , 2016, Acta medica Okayama.

[15]  K. Fearon.  Cachexia: Treat wasting illness on multiple fronts , 2016, Nature.

[16]  J. Long,et al.  Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. , 2016, Molecular pharmaceutics.

[17]  Horng-mo Lee,et al.  Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes , 2015, PloS one.

[18]  L. Ji.  Redox signaling in skeletal muscle: role of aging and exercise. , 2015, Advances in physiology education.

[19]  F. López‐Soriano,et al.  Combination of exercise training and erythropoietin prevents cancer-induced muscle alterations , 2015, Oncotarget.

[20]  J. Brown,et al.  Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration , 2015, Acta physiologica.

[21]  E. Debold.  Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species , 2015, Front. Physiol..

[22]  David E. Lee,et al.  Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice , 2015, Physiological reports.

[23]  Nobhojit Roy,et al.  The Global Burden of Cancer 2013. , 2015, JAMA oncology.

[24]  L. Scorrano,et al.  The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage , 2015, Cell metabolism.

[25]  S. Powers,et al.  Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin‐induced cardiac and skeletal muscle myopathy , 2015, The Journal of physiology.

[26]  M. Sandri,et al.  The role of alterations in mitochondrial dynamics and PGC‐1α over‐expression in fast muscle atrophy following hindlimb unloading , 2015, The Journal of physiology.

[27]  C. Reggiani.  Regulation of muscle mass: a new role for mitochondria? , 2015, The Journal of physiology.

[28]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[29]  A. Sivakumar,et al.  Effects of Sunphenon and Polyphenon 60 on proteolytic pathways, inflammatory cytokines and myogenic markers in H2O2-treated C2C12 cells , 2015, Journal of Biosciences.

[30]  R. Youle,et al.  The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease , 2015, Neuron.

[31]  M. Sandri,et al.  PGC1‐α over‐expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice , 2014, The Journal of physiology.

[32]  J. Davis,et al.  Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice. , 2014, The Journal of nutrition.

[33]  D. Guttridge,et al.  Inflammation Based Regulation of Cancer Cachexia , 2014, BioMed research international.

[34]  Jean A Donet,et al.  Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia, and Exercise Intolerance in Mice with Congestive Heart Failure , 2014, Circulation. Heart failure.

[35]  M. Driscoll,et al.  A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo* , 2014, The Journal of Biological Chemistry.

[36]  J. Carson,et al.  Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[37]  S. Schiaffino,et al.  Muscle type and fiber type specificity in muscle wasting. , 2013, The international journal of biochemistry & cell biology.

[38]  I. Salt,et al.  Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. , 2013, Clinical science.

[39]  D. Glass,et al.  Cancer cachexia: mediators, signaling, and metabolic pathways. , 2012, Cell metabolism.

[40]  R. Price,et al.  IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse , 2012, Skeletal Muscle.

[41]  J. Duarte,et al.  Mitochondrial signaling contributes to disuse muscle atrophy. , 2012, American journal of physiology. Endocrinology and metabolism.

[42]  Zhen Yan,et al.  Exercise Training-Induced Regulation of Mitochondrial Quality , 2012, Exercise and sport sciences reviews.

[43]  R. Youle,et al.  PINK1- and Parkin-mediated mitophagy at a glance , 2012, Journal of Cell Science.

[44]  S. Welle,et al.  The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse , 2011, PloS one.

[45]  M. Tisdale,et al.  Decreased NADPH oxidase expression and antioxidant activity in cachectic skeletal muscle , 2011, Journal of cachexia, sarcopenia and muscle.

[46]  G. Lamb,et al.  Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle , 2011, The Journal of physiology.

[47]  Paula Ravasco,et al.  Definition and classification of cancer cachexia: an international consensus. , 2011, The Lancet. Oncology.

[48]  J. Baynes,et al.  Muscle oxidative capacity during IL-6-dependent cancer cachexia. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

[49]  M. Mindrinos,et al.  Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia , 2010, International journal of molecular medicine.

[50]  M. Sandri,et al.  Mitochondrial Biogenesis and Fragmentation as Regulators of Muscle Protein Degradation , 2010, Current hypertension reports.

[51]  S. Powers,et al.  Oxidative stress is required for mechanical ventilation‐induced protease activation in the diaphragm , 2010, Journal of applied physiology.

[52]  R. Youle,et al.  Mechanisms of mitophagy , 2010, Nature Reviews Molecular Cell Biology.

[53]  P. Neufer,et al.  Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. , 2009, The Journal of clinical investigation.

[54]  S. Powers,et al.  Calpain-1 is required for hydrogen peroxide-induced myotube atrophy. , 2009, American journal of physiology. Cell physiology.

[55]  J. Davis,et al.  Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic ApcMin/+ mouse , 2009, Pflügers Archiv - European Journal of Physiology.

[56]  J. Stamler,et al.  Fiber Type-Specific Nitric Oxide Protects Oxidative Myofibers against Cachectic Stimuli , 2008, PloS one.

[57]  Olga Ilkayeva,et al.  Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. , 2008, Cell metabolism.

[58]  T. Letellier,et al.  Mitochondrial bioenergetics and structural network organization , 2007, Journal of Cell Science.

[59]  L. Mao,et al.  Oxidative phenotype protects myofibers from pathological insults induced by chronic heart failure in mice. , 2007, The American journal of pathology.

[60]  Xiaomei Ma,et al.  Global Burden of Cancer , 2006, The Yale journal of biology and medicine.

[61]  S. Kandarian,et al.  Intracellular signaling during skeletal muscle atrophy , 2006, Muscle & nerve.

[62]  M. Martín,et al.  N-acetyl-cysteine abolishes hydrogen peroxide-induced modification of eukaryotic initiation factor 4F activity via distinct signalling pathways. , 2006, Cellular signalling.

[63]  A. Jemal,et al.  Trends in the leading causes of death in the United States, 1970-2002. , 2005, JAMA.

[64]  J. Lemasters.  Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. , 2005, Rejuvenation research.

[65]  Jeffrey S. Damrauer,et al.  Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. , 2004, The Journal of clinical investigation.

[66]  Yi-Ping Li,et al.  Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes. , 2003, American journal of physiology. Cell physiology.

[67]  S. Powers,et al.  Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle , 1999, Proceedings of the Nutrition Society.

[68]  P. Puigserver,et al.  A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis , 1998, Cell.

[69]  J. Duarte,et al.  Supplementation of vitamin E may attenuate skeletal muscle immobilization atrophy. , 1997, International journal of sports medicine.

[70]  S. R. Max.  Disuse atrophy of skeletal muscle: loss of functional activity of mitochondria. , 1972, Biochemical and biophysical research communications.