Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I.

[1]  T. Werner,et al.  Homology cloning of GTP-cyclohydrolase I from various unrelated eukaryotes by reverse-transcription polymerase chain reaction using a general set of degenerate primers. , 1995, Biochemical and biophysical research communications.

[2]  O. Griffith,et al.  Nitric oxide synthases: properties and catalytic mechanism. , 1995, Annual review of physiology.

[3]  S. Tsuji,et al.  Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene , 1994, Nature Genetics.

[4]  T. Werner,et al.  Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity. , 1994, Biochemical and biophysical research communications.

[5]  T. Werner,et al.  Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme. , 1994, The Biochemical journal.

[6]  J. O'donnell,et al.  Multiple mRNAs from the Punch locus of Drosophila melanogaster encode isoforms of GTP cyclohydrolase I with distinct N-terminal domains. , 1993, The Journal of biological chemistry.

[7]  C. Schindler,et al.  The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor. , 1993, The Journal of biological chemistry.

[8]  I. Ziegler,et al.  Induction of GTP‐cyclohydrolase I mRNA expression by lectin activation and interferon‐γ treatment in human cells associated with the immune response , 1993, Journal of cellular physiology.

[9]  B. Kempkes,et al.  In a concerted action kit ligand and interleukin 3 control the synthesis of serotonin in murine bone marrow-derived mast cells. Up-regulation of GTP cyclohydrolase I and tryptophan 5-monooxygenase activity by the kit ligand. , 1993, The Journal of biological chemistry.

[10]  H. Kagamiyama,et al.  Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity. , 1993, Science.

[11]  K Frech,et al.  Computer-assisted prediction, classification, and delimitation of protein binding sites in nucleic acids. , 1993, Nucleic acids research.

[12]  T. Werner,et al.  Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA. , 1992, Biochimica et biophysica acta.

[13]  G. Crabtree,et al.  Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[14]  U. Lichter-Konecki,et al.  Structural characterization of the 5' regions of the human phenylalanine hydroxylase gene. , 1992, Biochemistry.

[15]  E. Werner,et al.  Impact of tumour necrosis factor-alpha and interferon-gamma on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages. , 1991, The Biochemical journal.

[16]  M. Karin,et al.  The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. , 1991, Biochimica et biophysica acta.

[17]  Gary K. Smith,et al.  Biosynthesis and function of tetrahydrobiopterin , 1991 .

[18]  P. Baeuerle,et al.  Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. , 1991, The EMBO journal.

[19]  J. Farber,et al.  5' regulatory region of a novel cytokine gene mediates selective activation by interferon gamma , 1991, The Journal of experimental medicine.

[20]  A. Bacher,et al.  Control of tetrahydrobiopterin synthesis in T lymphocytes by synergistic action of interferon-gamma and interleukin-2. , 1990, The Journal of biological chemistry.

[21]  A. Bacher,et al.  Synthesis of tetrahydrobiopterin in Friend erythroleukemia cells and its modulator effect on cell proliferation. , 1990, Experimental cell research.

[22]  C. Shih,et al.  Transcriptional activation and repression by cellular DNA-binding protein C/EBP , 1990, Journal of virology.

[23]  E. Werner,et al.  Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. , 1990, The Journal of biological chemistry.

[24]  I. Ziegler Production of pteridines during hematopoiesis and T‐lymphocyte proliferation: Potential participation in the control of cytokine signal transmission , 1990, Medicinal research reviews.

[25]  I. Ziegler,et al.  Modulation of interleukin 2 high‐affinity binding by lymphocyte‐derived tetrahydrobiopterin: Pterins as potential participants in the control of interleukin 2 receptor assembly , 1989, Journal of cellular biochemistry.

[26]  C. A. Nichol,et al.  Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species. , 1984, Life sciences.

[27]  D. Fuchs,et al.  Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma , 1984, The Journal of experimental medicine.

[28]  O. Hayaishi Molecular mechanisms of oxygen activation , 1974 .