Retrieval analysis of a hydroxyapatite-coated hip prosthesis.

A 61-year-old woman fitted with a hydroxyapatite (HA)-coated macrotexture all-purpose hip prosthesis died three weeks after implantation. The retrieved femoral and acetabular components were examined using contact roentgenograms, the back-scattered mode of the scanning electron microscope, and light microscopy. Newly formed bone was observed in the marrow spaces and along the morselized autograft bone chips, which had been surgically placed in the medullary canal at the time of implantation. New bone was observed along 10% of the HA surface of the femoral component and 20% of the acetabular component. Some bone was also observed connecting the surrounding bone chips to the HA coating. Light microscopy showed the presence of osteoid on 20% of the femoral component and on 40% of the acetabular component. HA coating on total hip prostheses appears to enhance early skeletal attachment, which may be attributed to the osteoconductive properties of the composite.

[1]  K. Bachus,et al.  Backscattered Electron Imaging: The Role in Calcified Tissue and Implant Analysis , 1990, Journal of biomaterials applications.

[2]  R. Holmes,et al.  Porous hydroxyapatite as a bone graft substitute in maxillary augmentation. An histometric study. , 1989, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[3]  Paul Ducheyne,et al.  Bioceramics: material characteristics versus in vivo behavior. , 1987, Journal of biomedical materials research.

[4]  R. Barrack,et al.  Quantitative analysis of tissue growth into human porous total hip components. , 1988, The Journal of arthroplasty.

[5]  C. Klein,et al.  Chemical implant fixation using hydroxyl-apatite coatings. The development of a human total hip prosthesis for chemical fixation to bone using hydroxyl-apatite coatings on titanium substrates. , 1987, Clinical orthopaedics and related research.

[6]  R. Bloebaum,et al.  A polymethyl methacrylate method for large specimens of mineralized bone with implants. , 1987, Stain technology.

[7]  C. Engh,et al.  Histologic analysis of a retrieved microporous-coated femoral prosthesis. A seven-year case report. , 1987, Clinical orthopaedics and related research.

[8]  D. Sartoris,et al.  Coralline hydroxyapatite bone-graft substitutes in a canine diaphyseal defect model. Radiographic-histometric correlation. , 1986, Investigative radiology.

[9]  C. Engh,et al.  Porous-coated hip replacement. The factors governing bone ingrowth, stress shielding, and clinical results. , 1987, The Journal of bone and joint surgery. British volume.

[10]  J. Galante,et al.  A comparative study of porous coatings in a weight-bearing total hip-arthroplasty model. , 1986, The Journal of bone and joint surgery. American volume.

[11]  R. Holmes,et al.  Porous hydroxyapatite as a bone-graft substitute in metaphyseal defects. A histometric study. , 1986, The Journal of bone and joint surgery. American volume.

[12]  S. Cook,et al.  Histologic and microradiographic analysis of a revised porous-coated anatomic (PCA) patellar component. A case report. , 1986, Clinical orthopaedics and related research.

[13]  R. Holmes,et al.  A coralline hydroxyapatite bone graft substitute. Preliminary report. , 1984, Clinical orthopaedics and related research.

[14]  D B Kimmel,et al.  A quantitative histologic study of bone turnover in young adult beagles , 1982, The Anatomical record.

[15]  B. Day,et al.  Circulatory and vascular changes in the hip following innominate osteotomy: an experimental study. , 1981, Clinical orthopaedics and related research.

[16]  W. Jee,et al.  The microvascular bed of fatty bone marrow in the adult beagle , 1980 .

[17]  R. Holmes,et al.  Bone Regeneration Within a Coralline Hydroxyapatite Implant , 1979, Plastic and reconstructive surgery.

[18]  F. Melsen,et al.  Dynamic studies of trabecular bone formation and osteoid maturation in normal and certain pathological conditions , 1978 .

[19]  R. Doremus,et al.  Tissue, cellular and subcellular events at a bone-ceramic hydroxylapatite interface. , 1977, Journal of bioengineering.

[20]  F. P. Patterson,et al.  Blood flow through different regions of long bone measured by a bone-seeking radioisotopic method. , 1971, Surgery, gynecology & obstetrics.

[21]  H. Sissons,et al.  CALCIUM ACCRETION AND BONE FORMATION IN DOGS: AN EXPERIMENTAL COMPARISON BETWEEN THE RESULTS OF CA-45 KINETIC ANALYSIS AND TETRACYCLINE LABELLING. , 1965, The Journal of bone and joint surgery. British volume.