High‐resolution multi‐voxel pattern analysis of category selectivity in the medial temporal lobes

Although the parahippocampal cortex (PHc) is known to be critical for memory formation, little is known about what is encoded by this area. Using multi‐voxel pattern analysis of high‐resolution functional magnetic resonance imaging (MRI) data, we examined responses to blocks of categorically coherent stimuli and found that patterns of activity in PHc were selective for not only scenes, but also for other nonspatial object categories (e.g., faces and toys). This pattern of results was also found in the parahippocampal place area (PPA), indicating that this region is not sensitive exclusively to scenes. In contrast, neither the hippocampus nor perirhinal cortex (PRc) were found to be selective for category information. The results indicate that regions within the medial temporal lobe may support distinct functions, and that the PHc appears to be particularly sensitive to category‐level information. © 2008 Wiley‐Liss, Inc.

[1]  M. Bar,et al.  Cortical Analysis of Visual Context , 2003, Neuron.

[2]  Alex Martin,et al.  Access the most recent version at doi: 10.1101/lm.251906 , 2006 .

[3]  E. Dumont,et al.  Effect of field strength on MR images: comparison of the same subject at 0.5, 1.0, and 1.5 T. , 1999, Radiographics : a review publication of the Radiological Society of North America, Inc.

[4]  Nancy Kanwisher,et al.  A cortical representation of the local visual environment , 1998, Nature.

[5]  Moshe Bar,et al.  Famous faces activate contextual associations in the parahippocampal cortex. , 2008, Cerebral cortex.

[6]  Mieke Verfaellie,et al.  Disproportionate deficit in associative recognition relative to item recognition in global amnesia , 2003, Cognitive, affective & behavioral neuroscience.

[7]  Sean M. Polyn,et al.  Beyond mind-reading: multi-voxel pattern analysis of fMRI data , 2006, Trends in Cognitive Sciences.

[8]  C. Koch,et al.  Imagery neurons in the human brain , 2000, Nature.

[9]  M. D’Esposito,et al.  A Trial-Based Experimental Design for fMRI , 1997, NeuroImage.

[10]  Sabrina M. Tom,et al.  Dissociable correlates of recollection and familiarity within the medial temporal lobes , 2004, Neuropsychologia.

[11]  Gabriele Janzen,et al.  Selective neural representation of objects relevant for navigation , 2004, Nature Neuroscience.

[12]  Vaidehi S. Natu,et al.  Category-Specific Cortical Activity Precedes Retrieval During Memory Search , 2005, Science.

[13]  H. Eichenbaum,et al.  The hippocampus--what does it do? , 1992, Behavioral and neural biology.

[14]  Rachel A. Diana,et al.  Imaging recollection and familiarity in the medial temporal lobe: a three-component model , 2007, Trends in Cognitive Sciences.

[15]  Alan C. Evans,et al.  Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. , 2000, Cerebral cortex.

[16]  David D. Cox,et al.  Functional magnetic resonance imaging (fMRI) “brain reading”: detecting and classifying distributed patterns of fMRI activity in human visual cortex , 2003, NeuroImage.

[17]  Aleix M. Martinez,et al.  The AR face database , 1998 .

[18]  Arnold W. M. Smeulders,et al.  The Amsterdam Library of Object Images , 2004, International Journal of Computer Vision.

[19]  C. Koch,et al.  Invariant visual representation by single neurons in the human brain , 2005, Nature.

[20]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited , 1995, NeuroImage.

[21]  L. Nadel,et al.  Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex , 1998, Neuropsychologia.

[22]  T. Bussey,et al.  Perceptual–mnemonic functions of the perirhinal cortex , 1999, Trends in Cognitive Sciences.

[23]  A. Martínez,et al.  The AR face databasae , 1998 .

[24]  A. Ishai,et al.  Distributed and Overlapping Representations of Faces and Objects in Ventral Temporal Cortex , 2001, Science.

[25]  Russell A. Epstein,et al.  The Parahippocampal Place Area Recognition, Navigation, or Encoding? , 1999, Neuron.

[26]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited—Again , 1995, NeuroImage.

[27]  H. Soininen,et al.  MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. , 1998, AJNR. American journal of neuroradiology.