Neural correlates of focused attention and cognitive monitoring in meditation

Meditation refers to a family of complex emotional and attentional regulatory practices, which can be classified into two main styles - focused attention (FA) and open monitoring (OM) - involving different attentional, cognitive monitoring and awareness processes. In a functional magnetic resonance study we originally characterized and contrasted FA and OM meditation forms within the same experiment, by an integrated FA-OM design. Theravada Buddhist monks, expert in both FA and OM meditation forms, and lay novices with 10 days of meditation practice, participated in the experiment. Our evidence suggests that expert meditators control cognitive engagement in conscious processing of sensory-related, thought and emotion contents, by massive self-regulation of fronto-parietal and insular areas in the left hemisphere, in a meditation state-dependent fashion. We also found that anterior cingulate and dorsolateral prefrontal cortices play antagonist roles in the executive control of the attention setting in meditation tasks. Our findings resolve the controversy between the hypothesis that meditative states are associated to transient hypofrontality or deactivation of executive brain areas, and evidence about the activation of executive brain areas in meditation. Finally, our study suggests that a functional reorganization of brain activity patterns for focused attention and cognitive monitoring takes place with mental practice, and that meditation-related neuroplasticity is crucially associated to a functional reorganization of activity patterns in prefrontal cortex and in the insula.

[1]  L. Carlson,et al.  One year pre–post intervention follow-up of psychological, immune, endocrine and blood pressure outcomes of mindfulness-based stress reduction (MBSR) in breast and prostate cancer outpatients , 2007, Brain, Behavior, and Immunity.

[2]  J. Pettigrew,et al.  Meditation alters perceptual rivalry in Tibetan Buddhist monks , 2005, Current Biology.

[3]  S. Rauch,et al.  Meditation experience is associated with increased cortical thickness , 2005, Neuroreport.

[4]  D. Heeger,et al.  Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1 , 1996, The Journal of Neuroscience.

[5]  Z. Segal,et al.  Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. , 2000, Journal of consulting and clinical psychology.

[6]  B. Baars.  IN THE THEATRE OF CONSCIOUSNESS Global Workspace Theory, A Rigorous Scientific Theory of Consciousness. , 1997 .

[7]  R. Davidson,et al.  The role of attention in meditation and hypnosis: a psychobiological perspective on transformations of consciousness. , 1977, The International journal of clinical and experimental hypnosis.

[8]  M. Posner,et al.  Cognitive and emotional influences in anterior cingulate cortex , 2000, Trends in Cognitive Sciences.

[9]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[10]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[11]  E. Rolls,et al.  The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology , 2004, Progress in Neurobiology.

[12]  M. Posner,et al.  Research on attention networks as a model for the integration of psychological science. , 2007, Annual review of psychology.

[13]  A. Luria.  The Working Brain: An Introduction To Neuropsychology , 1976 .

[14]  J. Coull.  Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology , 1998, Progress in Neurobiology.

[15]  M. Nicholls,et al.  Hemispheric differences in the rates of information processing for simple non-verbal stimuli , 1991, Neuropsychologia.

[16]  Iroise Dumontheil,et al.  The gateway hypothesis of rostral prefrontal cortex (area 10) function , 2007, Trends in Cognitive Sciences.

[17]  A. Morin,et al.  Self-awareness and the left inferior frontal gyrus: Inner speech use during self-related processing , 2007, Brain Research Bulletin.

[18]  A. Lutz,et al.  Attention regulation and monitoring in meditation , 2008, Trends in Cognitive Sciences.

[19]  Arne Dietrich,et al.  Functional neuroanatomy of altered states of consciousness: The transient hypofrontality hypothesis , 2003, Consciousness and Cognition.

[20]  A. Cavanna,et al.  The precuneus: a review of its functional anatomy and behavioural correlates. , 2006, Brain : a journal of neurology.

[21]  Markus Nowak,et al.  The mental self. , 2005, Progress in brain research.

[22]  P. Burgess,et al.  The gateway hypothesis of rostral PFC (area 10) function , 2007 .

[23]  M. Corbetta,et al.  Control of goal-directed and stimulus-driven attention in the brain , 2002, Nature Reviews Neuroscience.

[24]  Kristina M. Visscher,et al.  The neural bases of momentary lapses in attention , 2006, Nature Neuroscience.

[25]  J. Polich,et al.  Meditation states and traits: EEG, ERP, and neuroimaging studies. , 2006, Psychological bulletin.

[26]  Peter Fransson,et al.  The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis , 2008, NeuroImage.

[27]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[28]  T A Mondor,et al.  On the relation between auditory spatial attention and auditory perceptual asymmetries , 1992, Perception & psychophysics.

[29]  N. Farb,et al.  Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. , 2007, Social cognitive and affective neuroscience.

[30]  Antonino Raffone,et al.  The ‘I’ and the ‘Me’ in self-referential awareness: a neurocognitive hypothesis , 2010, Cognitive Processing.

[31]  E. Valentine,et al.  Meditation and attention: A comparison of the effects of concentrative and mindfulness meditation on sustained attention , 1999 .

[32]  R. Elliott,et al.  Dissociable functions in the medial and lateral orbitofrontal cortex: evidence from human neuroimaging studies. , 2000, Cerebral cortex.

[33]  M. Posner,et al.  Short-term meditation training improves attention and self-regulation , 2007, Proceedings of the National Academy of Sciences.

[34]  Narayanan Srinivasan,et al.  An adaptive workspace hypothesis about the neural correlates of consciousness: insights from neuroscience and meditation studies. , 2009, Progress in brain research.

[35]  Britta K. Hölzel,et al.  Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators , 2007, Neuroscience Letters.

[36]  Hillary S. Schaefer,et al.  Neural correlates of attentional expertise in long-term meditation practitioners , 2007, Proceedings of the National Academy of Sciences.

[37]  S. Nieuwenhuis,et al.  Mental Training Affects Distribution of Limited Brain Resources , 2007, PLoS biology.

[38]  Jillian H. Fecteau,et al.  Hemisphere differences in conscious and unconscious word reading , 2004, Consciousness and Cognition.

[39]  M. Gazzaniga,et al.  Principles of human brain organization derived from split-brain studies , 1995, Neuron.

[40]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.