Elastic modulus of prepared canine jejunum, a new vascular graft material

The submucosal connective tissue of the jejunum has been shown to be suitable for use as a vascular graft in preliminary dog studies. To partially characterize the mechanical properties of this new graft material, longitudinal stress (σ)-strain (ε)-data were obtained on 13 specimens of canine jejunum, stripped of its mucosal and external smooth-muscle layers. The ratio of stress to strain is the modulus of elasticity (E). It was found that the stress σ-strain ε-data fitted the expressionγ=K∈α very well. For a typical specimenγ=2.69×106∈2.33. The modulus of elasticity (E=γ1-1/αK1/α) was found to increase with increasing stress, ranging from about 2,000 to 9,000 mmHg. For the average specimenE=573γ0.57, where σ is in mmHg, (1 mmHg=133.3 Pascals).

[1]  A. Callow History of vascular graft development , 1986 .

[2]  L. Geddes,et al.  Continuous measurement of aortic radius changein vivo with an intra-aortic ultrasonic catheter , 1985, Medical and Biological Engineering and Computing.

[3]  B. S. Gow,et al.  Measurement of Viscoelastic Properties of Arteries in the Living Dog , 1968, Circulation research.

[4]  L A Geddes,et al.  Small intestinal submucosa as a small-diameter arterial graft in the dog. , 1990, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[5]  L A Geddes,et al.  Small intestinal submucosa as a large diameter vascular graft in the dog. , 1989, The Journal of surgical research.

[6]  A. Jaretzki,et al.  The use of tubes constructed from vinyon "N" cloth in bridging arterial defects. , 1952, Annals of surgery.

[7]  P N SAWYER,et al.  The compound prosthetic vascular graft: a pathologic survey. , 1963, Surgery.

[8]  D E Strandness,et al.  Stress-strain characteristics and collagen-elastin content of abdominal aortic aneurysms. , 1970, Surgery, gynecology & obstetrics.

[9]  D. Bergel The static elastic properties of the arterial wall , 1961, The Journal of physiology.

[10]  P. Sawyer Biophysical Mechanisms in Vascular Homeostatis and Intravascular Thrombosis , 1966 .

[11]  A. Blakemore,et al.  THE USE OF TUBES CONSTRUCTED FROM VINYON “N” CLOTH IN BRIDGING ARTERIAL DEFECTS—EXPERIMENTAL AND CLINICAL , 1954, Annals of surgery.

[12]  P. E. Paasche,et al.  Stress at vascular anastomoses in relation to host artery:synthetic graft diameter. , 1974, Canadian journal of surgery. Journal canadien de chirurgie.

[13]  L. A. Geddes,et al.  Measurement of the modulus of elasticity of the arterial wall , 1973 .

[14]  D. Bergel,et al.  The dynamic elastic properties of the arterial wall , 1961, The Journal of physiology.

[15]  Kinley Ce,et al.  Stress at vascular anastomosis in relation to host artery: synthetic graft diameter. , 1974 .

[16]  YOUNG'S MODULUS AND BREAKING STRENGTH OF BODY TISSUES. , 1964 .

[17]  D. Lyman,et al.  Effect of elasticity of prosthetic wall on patency of small-diameter arterial prostheses. , 1979, Surgical forum.

[18]  H. Kambic,et al.  Vascular Graft Update: Safety and Performance , 1986 .

[19]  M. Debakey,et al.  Porosity: primary determinant of ultimate fate of synthetic vascular grafts. , 1961 .

[20]  D. Hokanson,et al.  Arterial walls before and after endarterectomy. Stress-strain characteristics and collagen-elastin content. , 1969, Archives of surgery.