Impact of current and past blood pressure on retinal arteriolar diameter in an older population

Objective To examine the effects of current and past blood pressure on retinal arteriolar diameter in a general older population. Design Cross-sectional and longitudinal studies. Setting Population-based cohort study of older residents from an area west of Sydney, Australia. Participants Two thousand three hundred and thirty-five individuals (n = 2335) (aged ⩾ 54 years) who attended the 5-year follow-up Blue Mountains Eye Study during 1997–99. Main outcome measures A computer-assisted method measured vessel diameters from digitized right eye retinal photographs. The narrowest quintile of central retinal arteriolar equivalent or arteriole-to-venule ratio (AVR) defined generalized arteriolar narrowing. Blood pressure was measured using a mercury sphygmomanometer. Results After simultaneous adjustment for age, sex, body mass index, smoking and current or past blood pressure, elevated levels of both current and past blood pressure were associated with narrower retinal arterioles [Ptrend = 0.009 and 0.007 for current and past systolic blood pressure (SBP), respectively] and lower AVR [Ptrend = 0.001 and 0.0009 for current and past diastolic blood pressure (DBP), respectively]. Generalized arteriolar narrowing was associated with both current blood pressure [adjusted odds ratio (OR) 2.4, 95% confidence interval (CI) 1.5–3.8 for the highest versus lowest quintile of current DBP] and past blood pressure (adjusted OR 1.7, 95% CI 1.1–2.6, for the highest versus lowest quintile of past DBP). Hypertension duration or control status at baseline had no additional effect on arteriolar diameter after adjusting for current blood pressure. Conclusions Our data document the independent effects of both current and past blood pressure on small vessel calibre in the retina, suggesting that retinal arteriolar narrowing may result from the cumulative effects of long-standing hypertension.

[1]  R. Klein,et al.  Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study , 2001, The Lancet.

[2]  M. Tso,et al.  Pathophysiology of hypertensive retinopathy. , 1982, Ophthalmology.

[3]  E. Kohner,et al.  Retinal vessel measurement: comparison between observer and computer driven methods , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[4]  J. Whitworth,et al.  2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension , 2003, Journal of hypertension.

[5]  R. Klein,et al.  Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. , 1999, American journal of epidemiology.

[6]  Paul Mitchell,et al.  Computer‐assisted retinal vessel measurement in an older population: correlation between right and left eyes , 2003, Clinical & experimental ophthalmology.

[7]  R. Gifford,et al.  Essential Hypertension: A Twenty‐Year Follow‐Up Study , 1966 .

[8]  J. C. Parr,et al.  General caliber of the retinal arteries expressed as the equivalent width of the central retinal artery. , 1974, American journal of ophthalmology.

[9]  A. Harnish,et al.  EVOLUTION OF HYPERTENSIVE RETINAL VASCULAR DISEASE: CORRELATION BETWEEN CLINICAL AND POSTMORTEM OBSERVATIONS , 1973, Medicine.

[10]  J. C. Parr Hypertensive generalised narrowing of retinal arteries. , 1974, Transactions of the Ophthalmological Society of New Zealand.

[11]  R. Klein,et al.  Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. , 1999, Ophthalmology.

[12]  R. Kronmal,et al.  Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study , 2002, The British journal of ophthalmology.

[13]  T. Kearns,et al.  Prognostic importance of ophthalmoscopic findings in essential hypertension. , 1966, Journal of the American Medical Association (JAMA).

[14]  E. Aurell,et al.  Hypertensive eye ground changes. Prevalence, relation to blood pressure and prognostic importance. The study of men born in 1913. , 2009, Acta medica Scandinavica.

[15]  Tien Yin Wong,et al.  Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons. , 2002, JAMA.

[16]  R. Klein,et al.  Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. , 2002, JAMA.

[17]  R. Klein,et al.  Relationships between age, blood pressure, and retinal vessel diameters in an older population. , 2003, Investigative ophthalmology & visual science.

[18]  Paul Mitchell,et al.  Reliability of computer‐assisted retinal vessel measurement in a population , 2002, Clinical & experimental ophthalmology.

[19]  R. Klein,et al.  Hypertensive Retinal Vessel Wall Signs in a General Older Population: The Blue Mountains Eye Study , 2003, Hypertension.

[20]  J. Vandenbroucke,et al.  Retinopathy as an independent indicator of all-causes mortality. , 1986, International journal of epidemiology.