Merger of dynamic two-photon and phosphorescence lifetime microscopy reveals dependence of lymphocyte motility on oxygen in solid and hematological tumors

[1]  C. Ager,et al.  Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy , 2018, The Journal of clinical investigation.

[2]  I. Amelio,et al.  The hypoxic tumour microenvironment , 2018, Oncogenesis.

[3]  J. Gribben,et al.  Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia , 2017, Cancer cell.

[4]  Ruoning Wang,et al.  MYC and HIF in shaping immune response and immune metabolism. , 2017, Cytokine & growth factor reviews.

[5]  M. Konopleva,et al.  Integration of hypoxic HIF-α signaling in blood cancers , 2017, Oncogene.

[6]  S. Chouaib,et al.  Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer , 2017, Oncogene.

[7]  Y. Belkaid,et al.  Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche , 2016, Cell.

[8]  A. Giaccia,et al.  The ever-expanding role of HIF in tumour and stromal biology , 2016, Nature Cell Biology.

[9]  Frederic Bartumeus,et al.  T cell migration, search strategies and mechanisms , 2016, Nature Reviews Immunology.

[10]  M. Schäfers,et al.  A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level , 2016, The EMBO journal.

[11]  R. McKenna,et al.  Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function , 2015, Scientific Reports.

[12]  M. Sitkovsky,et al.  Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators , 2015, Oncoimmunology.

[13]  M. Konopleva,et al.  Role of Microenvironment in Resistance to Therapy in AML , 2015, Current Hematologic Malignancy Reports.

[14]  David F Wilson.  Programming and regulation of metabolic homeostasis. , 2015, American journal of physiology. Endocrinology and metabolism.

[15]  Akio Ohta,et al.  Immunological mechanisms of the antitumor effects of supplemental oxygenation , 2015, Science Translational Medicine.

[16]  J. Locasale,et al.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. , 2015, The Journal of clinical investigation.

[17]  Anders M. Dale,et al.  Large arteriolar component of oxygen delivery implies safe margin of oxygen supply to cerebral tissue , 2014, Nature Communications.

[18]  Sergei A. Vinogradov,et al.  Two-Photon Antenna-Core Oxygen Probe with Enhanced Performance , 2014, Analytical chemistry.

[19]  Sergei A. Vinogradov,et al.  Direct measurement of local oxygen concentration in the bone marrow of live animals , 2014, Nature.

[20]  Chih-Hao Chang,et al.  Fueling Immunity: Insights into Metabolism and Lymphocyte Function , 2013, Science.

[21]  P. Muranski,et al.  Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. , 2013, The Journal of clinical investigation.

[22]  M. Konopleva,et al.  Targeting hypoxia in the leukemia microenvironment. , 2013, International journal of hematologic oncology.

[23]  J. Schenkel,et al.  The integration of T cell migration, differentiation and function , 2013, Nature Reviews Immunology.

[24]  Scott S. Howard,et al.  Frequency Multiplexed In Vivo Multiphoton Phosphorescence Lifetime Microscopy , 2012, Nature Photonics.

[25]  G. V. D. Windt,et al.  Metabolic switching and fuel choice during T‐cell differentiation and memory development , 2012, Immunological reviews.

[26]  M. Konopleva,et al.  Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment , 2012, Cancer biology & therapy.

[27]  D. Green,et al.  The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. , 2011, Immunity.

[28]  Alexander I. Karagodov,et al.  Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging. , 2011, Analytical chemistry.

[29]  Anna Devor,et al.  “Overshoot” of O2 Is Required to Maintain Baseline Tissue Oxygenation at Locations Distal to Blood Vessels , 2011, The Journal of Neuroscience.

[30]  D. Campana,et al.  Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104 , 2011, PloS one.

[31]  Qiyin Fang,et al.  Effects of incomplete decay in fluorescence lifetime estimation , 2011, Biomedical optics express.

[32]  M. Ducros,et al.  Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels , 2011, Nature Medicine.

[33]  G. Fuller,et al.  Hypoxia Potentiates Glioma-Mediated Immunosuppression , 2011, PloS one.

[34]  Emiri T. Mandeville,et al.  Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue , 2010, Nature Methods.

[35]  Emmanuel Roussakis,et al.  Two-photon microscopy of oxygen: polymersomes as probe carrier vehicles. , 2010, The journal of physical chemistry. B.

[36]  Feng Gao,et al.  Oxygen microscopy by two-photon-excited phosphorescence. , 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

[37]  M. Sitkovsky,et al.  Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors , 2005, Nature Reviews Immunology.

[38]  Randall L. Lindquist,et al.  Visualizing dendritic cell networks in vivo , 2004, Nature Immunology.

[39]  J. Brown,et al.  Exploiting tumour hypoxia in cancer treatment , 2004, Nature Reviews Cancer.

[40]  Mark A Rizzo,et al.  An improved cyan fluorescent protein variant useful for FRET , 2004, Nature Biotechnology.

[41]  C. Thompson,et al.  The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.

[42]  A S Kennedy,et al.  Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. , 1998, Gynecologic oncology.

[43]  D. Kioussis,et al.  Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. , 1995, Journal of immunological methods.

[44]  P. Keng,et al.  Lymphocytic infiltration and cytotoxicity under hypoxic conditions in the EMT6 mouse mammary tumor , 1990, International journal of cancer.

[45]  W. Rumsey,et al.  Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue. , 1988, Science.

[46]  J. Vanderkooi,et al.  An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. , 1987, The Journal of biological chemistry.