Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.

[1]  P. Beaune,et al.  Expression and localization of CYP3A4 and CYP3A5 in human lung. , 1997, American journal of respiratory cell and molecular biology.

[2]  F. Berthou,et al.  Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. , 1996, Carcinogenesis.

[3]  H. Yamazaki,et al.  Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[4]  P. Dayer,et al.  The effect of tobacco on lung cancer risk depends on CYP2D6 activity. , 1996, Cancer research.

[5]  C. Harris,et al.  Articles activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2 , 1994, Molecular carcinogenesis.

[6]  J. Morizet,et al.  Main drug- and carcinogen-metabolizing enzyme systems in human non-small cell lung cancer and peritumoral tissues. , 1993, Cancer research.

[7]  F. Gonzalez,et al.  Analysis of human cytochrome P450 catalytic activities and expression. , 1992, The Tohoku journal of experimental medicine.

[8]  S. Wrighton,et al.  Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA. , 1992, Biochemical pharmacology.

[9]  H. Bartsch,et al.  Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients , 1991, International journal of cancer.

[10]  M. Boyd,et al.  Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. , 1990, Journal of the National Cancer Institute.

[11]  C. Jefcoate,et al.  Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. , 1990, Carcinogenesis.

[12]  T. Aoyama,et al.  cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. , 1989, Biochemistry.

[13]  C. Harris,et al.  Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair. , 1989, Carcinogenesis.

[14]  C. Harris,et al.  Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. , 1988, Cancer research.

[15]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[16]  J. Lechner,et al.  A serum-free method for culturing normal human bronchial epithelial cells at clonal density , 1985 .

[17]  John Doull,et al.  Casarett and Doull's toxicology : the basic science of poisons , 2001 .

[18]  C. Harris,et al.  Explant culture of human peripheral lung. I. Metabolism of benzo[alpha]pyrene. , 1978, Laboratory investigation; a journal of technical methods and pathology.

[19]  C. Harris,et al.  Metabolism of dimethylnitrosamine and 1,2-dimethylhydrazine in cultured human bronchi. , 1977, Cancer research.

[20]  C. Harris,et al.  Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. , 1976, Science.

[21]  J. Castell,et al.  In vitro methods in pharmaceutical research , 1997 .

[22]  A. Pfeifer,et al.  18 – Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells , 1996 .

[23]  C. J. Omiecinski,et al.  Expression of cytochrome P450s and microsomal epoxide hydrolase in primary cultures of human umbilical vein endothelial cells. , 1994, Toxicology and applied pharmacology.

[24]  C. Smith,et al.  Genetic polymorphisms in xenobiotic metabolism. , 1994, European journal of cancer.

[25]  F. Gonzalez,et al.  Human cytochromes P450: problems and prospects. , 1992, Trends in pharmacological sciences.

[26]  G. Webb,et al.  Genetic heterogeneity of the human glutathione transferases: a complex of gene families. , 1990, Pharmacology & therapeutics.