Linear and Fast Hydrogel Glucose Sensor Materials Enabled by Volume Resetting Agents

A volume resetting agent is incorporated into a boronic acid functionalized hydrogel containing an embedded photonic crystal, yielding a glucose sensor material with a linear and fast response, minimal hysteresis, and good stability under simulated physiological conditions. The hydrogel can be tuned to modulate both the sensitivity and kinetics.

[1]  S. Wereley,et al.  soft matter , 2019, Science.

[2]  V. Lynch,et al.  A structural investigation of the N-B interaction in an o-(N,N-dialkylaminomethyl)arylboronate system. , 2006, Journal of the American Chemical Society.

[3]  Byron E. Collins,et al.  Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids. , 2009, The Journal of organic chemistry.

[4]  A. Horgan,et al.  Continuous blood glucose monitoring with a thin-film optical sensor. , 2007, Clinical chemistry.

[5]  A. Basu,et al.  3-Methoxycarbonyl-5-nitrophenyl boronic acid: high affinity diol recognition at neutral pH. , 2004, Bioorganic & medicinal chemistry letters.

[6]  O. Wolfbeis,et al.  Boronic acid based probes for microdetermination of saccharides and glycosylated biomolecules , 2008 .

[7]  B. Ziaie,et al.  Novel swelling/shrinking behaviors of glucose-binding hydrogels and their potential use in a microfluidic insulin delivery system , 2004 .

[8]  L. Janssen,et al.  Diffusion coefficients of oxygen, hydrogen peroxide and glucose in a hydrogel , 1993 .

[9]  T. James,et al.  Glucose sensing via aggregation and the use of "knock-out" binding to improve selectivity. , 2013, Journal of the American Chemical Society.

[10]  D. Hall Boronic acids : preparation and applications in organic synthesis, medicine and materials , 2011 .

[11]  R. Siegel,et al.  Swelling Properties of Hydrogels Containing Phenylboronic Acids , 2013 .

[12]  Zhefu Chen,et al.  Organization of glucose-responsive systems and their properties. , 2011, Chemical reviews.

[13]  Yongjun Zhang,et al.  Layer-by-layer multilayer films linked with reversible boronate ester bonds with glucose-sensitivity under physiological conditions , 2009 .

[14]  R. Pizer,et al.  Equilibria and reaction mechanism of the complexation of methylboronic acid with polyols , 1992 .

[15]  J. C. Norrild,et al.  A fluorescent glucose sensor binding covalently to all five hydroxy groups of α-D-glucofuranose. A reinvestigation , 1999 .

[16]  M Schetz,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[17]  M. Shults,et al.  A subcutaneous glucose sensor with improved longevity, dynamic range, and stability of calibration. , 2000, Diabetes care.

[18]  R. Holman,et al.  Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. , 1999, JAMA.

[19]  L. Heinemann,et al.  Sensors for glucose monitoring: technical and clinical aspects , 2001, Diabetes/metabolism research and reviews.

[20]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[21]  L. Andrew Lyon,et al.  Bioresponsive hydrogels for sensing applications , 2009 .

[22]  Reese,et al.  Synthesis of Highly Charged, Monodisperse Polystyrene Colloidal Particles for the Fabrication of Photonic Crystals. , 2000, Journal of colloid and interface science.

[23]  Igor K Lednev,et al.  Photonic crystal carbohydrate sensors: low ionic strength sugar sensing. , 2003, Journal of the American Chemical Society.

[24]  T. Okano,et al.  Glucose‐responsive complex formation between poly(vinyl alcohol) and poly(N‐vinyl‐2‐pyrrolidone) with pendent phenylboronic acid moieties , 1991 .

[25]  G. Wulff,et al.  Selective binding to polymers via covalent bonds. The construction of chiral cavities as specific receptor sites , 1982 .

[26]  Dag Roar Hjelme,et al.  Determination of glucose levels using a functionalized hydrogel-optical fiber biosensor: toward continuous monitoring of blood glucose in vivo. , 2009, Analytical chemistry.

[27]  S. Asher,et al.  Polymerized colloidal crystal hydrogel films as intelligent chemical sensing materials , 1997, Nature.

[28]  T. Okano,et al.  Preparation and characterization of a glucose-responsive insulin-releasing polymer device. , 1994, Biomaterials.

[29]  Warszawski Uniwersytet Medyczny,et al.  Diabetes care , 2019, Health at a Glance.

[30]  Igor K Lednev,et al.  High ionic strength glucose-sensing photonic crystal. , 2003, Analytical chemistry.

[31]  D. Klonoff Continuous glucose monitoring: roadmap for 21st century diabetes therapy. , 2005, Diabetes care.

[32]  Joseph Wang Electrochemical glucose biosensors. , 2008, Chemical reviews.

[33]  S. Shinkai,et al.  A Glucose-Selective Molecular Fluorescence Sensor† , 1994 .

[34]  Mark D. Losego,et al.  Hydrogel-Based Glucose Sensors: Effects of Phenylboronic Acid Chemical Structure on Response , 2013 .

[35]  G. Van den Berghe,et al.  Intensive insulin therapy in the medical ICU. , 2006, The New England journal of medicine.

[36]  Peter Steenbergen,et al.  Crosslinking Mechanism of Boric Acid with Diols Revisited , 2005 .

[37]  R. Holman,et al.  Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. , 1998 .

[38]  S. Asher,et al.  Photonic crystal borax competitive binding carbohydrate sensing motif. , 2009, The Analyst.

[39]  Yuandong Gu,et al.  Hard and soft micro- and nanofabrication: An integrated approach to hydrogel-based biosensing and drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[40]  S. Asher,et al.  Modeling of stimulated hydrogel volume changes in photonic crystal Pb2+ sensing materials. , 2005, Journal of the American Chemical Society.

[41]  S. Asher,et al.  Polymerized crystalline colloidal array sensing of high glucose concentrations. , 2009, Analytical chemistry.

[42]  H Hoshino,et al.  Glucose-sensing electrode coated with polymer complex gel containing phenylboronic Acid. , 1996, Analytical chemistry.

[43]  Binghe Wang,et al.  Progress in Boronic Acid-Based Fluorescent Glucose Sensors , 2004, Journal of Fluorescence.

[44]  John O. Edwards,et al.  Polyol Complexes and Structure of the Benzeneboronate Ion , 1959 .

[45]  R. Misra,et al.  Biomaterials , 2008 .

[46]  Yongjun Zhang,et al.  Ultrathin hydrogel films for rapid optical biosensing. , 2012, Biomacromolecules.