Three new cembranoids from the Bornean soft coral Nephthea sp.

Abstract Three new cembranoid diterpenes, 10-hydroxy-nephthenol acetate (1), 7,8-epoxy-10-hydroxy-nephthenol acetate (2), and 6-acetoxy-7,8-epoxy-10-hydroxy-nephthenol acetate (3), along with a known compound, 6-acetoxy-7,8-epoxy-nephthenol acetate (4), were isolated from the Bornean soft coral Nephthea sp. Antibacterial and anticancer activities were exhibited by compounds 1 and 2 against Staphylococcus aureus (ATCC 6538)/Escherichia coli (ATCC 13311) and Hela/MCF-7, respectively.

[1]  Z. Wen,et al.  New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris , 2015, Marine drugs.

[2]  Y. Koay,et al.  Chemical Constituents and Biological Properties of the Marine Soft Coral Nephthea: A Review (Part 1) , 2012 .

[3]  R. Ueoka,et al.  Bioactive secondary metabolites from the Borneon soft corals of the genus nephthea , 2010 .

[4]  C. Vairappan,et al.  A New Cembrane Diterpene from the Bornean Soft Coral Nephthea sp , 2010, Molecules.

[5]  T. Ishii,et al.  A New Norsesquiterpenoid from a Bornean Soft Coral Genus Nephthea , 2009, Molecules.

[6]  C. Vairappan,et al.  A New 4α-Methylated Sterol from a Nephthea sp. (Nephtheidae) Bornean Soft Coral , 2009, Molecules.

[7]  M. Ghannoum,et al.  Optimal Susceptibility Testing Conditions for Detection of Azole Resistance in Aspergillus spp.: NCCLS Collaborative Evaluation , 2001, Antimicrobial Agents and Chemotherapy.

[8]  C. Dai,et al.  Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule. , 2000, Journal of natural products.

[9]  J. Pezzuto,et al.  Structurally Novel Bioconversion Products of the Marine Natural Product Sarcophine Effectively Inhibit JB6 Cell Transformation. , 1998, The Journal of organic chemistry.

[10]  Yuexian Li,et al.  New Marine Cembrane Diterpenoids Isolated from the Caribbean Gorgonian Eunicea mammosa , 1993 .

[11]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[12]  Hulse Ev.  Tumours of the Skin and other Delayed Effects of External Beta Irradiation of Mice Using 90Sr and 32P , 1962, British Journal of Cancer.

[13]  J. Coll,et al.  Studies of Australian soft corals. XXIX. Several new cembranoid diterpenes from Nephthea brassica and related diterpenes from a Sarcophyton species , 1982 .