论文信息 - Estudo multicŒntrico comparativo entre Felodipina e Captopril como monoterapia em pacientes com hipertensªo leve a moderada

Estudo multicŒntrico comparativo entre Felodipina e Captopril como monoterapia em pacientes com hipertensªo leve a moderada

Comparamos a eficacia antihipertensiva e a tolerabilidade da Felodipina com o Captopril. Estudamos pacientes que apos quatro semanas de placebo (PAD entre 95 e 110mmHg), receberam por quatro semanas de maneira duplo cega Felodipina 5mg/dia (n=43) ou Captopril 50mg/dia (n=39). Nos dois grupos houve queda progressiva da pressao (diferencas significativas em relacao ao placebo). Nao houve diferencas entre as duas drogas quanto a pressao e a frequencia cardiaca. Os efeitos adversos foram discretos. Concluimos que Felodipina (5mg/dia) e Captopril (50mg/dia) sao regimes terapeuticos igualmente eficazes como monoterapia no controle da hipertensao leve/moderada, tendo poucos efeitos colaterais e com a vantagem da Felodipina poder ser administrada em dose unica diaria.

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