Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

[1]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[2]  T. Gould,et al.  The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders , 2015, Science Translational Medicine.

[3]  A. A. Romanovsky,et al.  Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes , 2013, Frontiers in Neuroendocrinology.

[4]  L. Prokai,et al.  Separation of dansylated 17β-estradiol, 17α-estradiol, and estrone on a single HPLC column for simultaneous quantitation by LC–MS/MS , 2013, Analytical and Bioanalytical Chemistry.

[5]  Dorothee Girbig,et al.  Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease , 2012, Menopause.

[6]  Dorothee Girbig,et al.  A dynamic model of circadian rhythms in rodent tail skin temperature for comparison of drug effects , 2012, Journal of circadian rhythms.

[7]  H. Wilkinson,et al.  Control of rat tail skin temperature regulation by estrogen receptor-beta selective ligand. , 2009, Maturitas.

[8]  C. Loprinzi,et al.  On hot flash mechanism, measurement, and treatment , 2009, Menopause.

[9]  Thomas D. Schmittgen,et al.  Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.

[10]  A. Holmes,et al.  Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain , 2008, Neuropsychopharmacology.

[11]  C. Soares,et al.  Treatment of depression and menopause-related symptoms with the serotonin-norepinephrine reuptake inhibitor duloxetine. , 2007, The Journal of clinical psychiatry.

[12]  L. Prokai,et al.  A Facile Microwave‐Assisted Synthesis of p‐Quinols by Lead(IV) Acetate Oxidation. , 2007 .

[13]  L. Leventhal,et al.  Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models. , 2007, Endocrinology.

[14]  Rongwei Fu,et al.  Management of Miscarriage: Expectant, Medical, or Surgical? Results of Randomised Controlled Trial (Miscarriage Treatment [MIST] Trial) , 2006, Annals of internal medicine.

[15]  D. Kimmel,et al.  Estrogenic control of thermoregulation in ERαKO and ERβKO mice , 2006 .

[16]  Roger B. Davis,et al.  After the Women's Health Initiative: decision making and trust of women taking hormone therapy. , 2005, Women's health issues : official publication of the Jacobs Institute of Women's Health.

[17]  L. Leventhal,et al.  Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction , 2004, Brain Research.

[18]  Eric S Manas,et al.  Structure-based design of estrogen receptor-beta selective ligands. , 2004, Journal of the American Chemical Society.

[19]  B. Katzenellenbogen,et al.  Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues in Vivo through the Use of an ERα-Selective Ligand , 2002 .

[20]  C. Kooperberg,et al.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. , 2002, JAMA.

[21]  R. Freedman,et al.  Estrogen raises the sweating threshold in postmenopausal women with hot flashes. , 2002, Fertility and sterility.

[22]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[23]  R R Freedman,et al.  Physiology of hot flashes , 2001, American journal of human biology : the official journal of the Human Biology Council.

[24]  H. Berendsen,et al.  Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats. , 2001, European journal of pharmacology.

[25]  I. Merchenthaler,et al.  Evidence of the Colocalization of Estrogen Receptor-β mRNA and Estrogen Receptor-α Immunoreactivity in Neurons of the Rat Forebrain. , 1998, Endocrinology.

[26]  R. Winneker,et al.  The effect of estrogens and antiestrogens in a rat model for hot flush. , 1998, Maturitas.

[27]  E. Perez,et al.  Pilot evaluation of venlafaxine hydrochloride for the therapy of hot flashes in cancer survivors. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  I. Merchenthaler,et al.  Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study. , 1997, Endocrinology.

[29]  P. Shughrue,et al.  In situ hybridization analysis of the distribution of neurokinin‐3 mRNA in the rat central nervous system , 1996, The Journal of comparative neurology.

[30]  M. Gašić,et al.  A novel m-CPBA oxidation: p-quinols and epoxyquinols from phenols , 1996 .

[31]  W. Yue,et al.  Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model. , 1995, Cancer research.

[32]  Y. Ouchi,et al.  Vascular smooth muscle cells as target for estrogen. , 1993, Biochemical and biophysical research communications.

[33]  Fredi Kronenberg,et al.  Hot Flashes: Epidemiology and Physiologya , 1990, Annals of the New York Academy of Sciences.

[34]  Toshiharu Yamamoto,et al.  Estrogen induction of galanin synthesis in the rat anterior pituitary gland demonstrated by in situ hybridization and immunohistochemistry , 1989, Neuroscience Letters.

[35]  J. B. Martin,et al.  Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[36]  W. Chesarek,et al.  Postmenopausal hot flushes: a disorder of thermoregulation. , 1980, Maturitas.

[37]  M. Sibony,et al.  An In Situ Hybridization Study , 2005 .

[38]  B. Long,et al.  Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[39]  I. Merchenthaler,et al.  Evidence for the colocalization of estrogen receptor-beta mRNA and estrogen receptor-alpha immunoreactivity in neurons of the rat forebrain. , 1998, Endocrinology.